BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY

Detalhes bibliográficos
Autor(a) principal: Ramos, Leonor
Data de Publicação: 2015
Outros Autores: Simões, Pedro, Gouveia, Miguel, Pereira, Neide, Cardoso, José Carlos, Figueiredo, Américo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.72.4.335
Resumo: Breast angiosarcoma is a rare tumor that can be divided in 3 groups: primary, secondary to chronic lymphoedema and secondary to radiotherapy (RT). It has a poor prognosis and a bad response to surgery and chemotherapy (QT). A female patient was observed with a very indurated erythematous-violaceous plaque, with an ecchymotic halo that occupied the right breast, and was evolving for 8 months. The patient had history of breast cancer, treated with surgery (tumourectomy) and local RT 5 years before. The incisional biopsy showed a vascular proliferation, arranged in nodules but also with diffuse growing, with cytological atypia and strong expression of CD31, CD34 and factor VIII, consistent with post-RT angiosarcoma. The patient begun RT and QT, but had no significant clinical response. She is now waiting for approval to begin pazopanib.
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spelling BREAST ANGIOSSARCOMA AFTER RADIOTHERAPYANGIOSSARCOMA DA MAMA APÓS RADIOTERAPIABreast neoplasmsHemangiosarcomaRadiotherapyAngiossarcomaNeoplasias da mamaRadioterapiaBreast angiosarcoma is a rare tumor that can be divided in 3 groups: primary, secondary to chronic lymphoedema and secondary to radiotherapy (RT). It has a poor prognosis and a bad response to surgery and chemotherapy (QT). A female patient was observed with a very indurated erythematous-violaceous plaque, with an ecchymotic halo that occupied the right breast, and was evolving for 8 months. The patient had history of breast cancer, treated with surgery (tumourectomy) and local RT 5 years before. The incisional biopsy showed a vascular proliferation, arranged in nodules but also with diffuse growing, with cytological atypia and strong expression of CD31, CD34 and factor VIII, consistent with post-RT angiosarcoma. The patient begun RT and QT, but had no significant clinical response. She is now waiting for approval to begin pazopanib.O angiossarcoma da mama é uma neoplasia pouco frequente que se pode classificar em 3 grupos: primário, secundário a linfedema crónico e secundário a radioterapia (RT). Tem por norma mau prognóstico, com má resposta a cirurgia e quimioterapia (QT). Uma doente do sexo feminino foi observada com placa de coloração eritematoviolácea, com halo equimótico periférico, de consistência muito endurecida, que ocupava a mama direita com 8 meses de evolução. Havia história prévia de carcinoma ductal invasivo da mama direita, submetido a tumorectomia e RT local adjuvante 5 anos antes. A biópsia incisional revelou proliferação vascular nodular e difusa, com atipia citológica marcada e expressão intensa de CD31, CD34 e factor VIII, compatível com angiossarcoma pós-RT. A doente foi encaminhada para a Unidade de Tumores Ósseos e de Tecidos moles, tendo iniciado RT e QT neo-adjuvante, sem resposta significativa. Está neste momento a aguardar tratamento com pazopanib.Sociedade Portuguesa de Dermatologia e Venereologia2015-04-13T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.72.4.335oai:ojs.revista.spdv.com.pt:article/335Journal of the Portuguese Society of Dermatology and Venereology; Vol 72 No 4 (2014): Outubro - Dezembro; 593-597Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 72 n. 4 (2014): Outubro - Dezembro; 593-5972182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/335https://doi.org/10.29021/spdv.72.4.335https://revista.spdv.com.pt/index.php/spdv/article/view/335/308Ramos, LeonorSimões, PedroGouveia, MiguelPereira, NeideCardoso, José CarlosFigueiredo, Américoinfo:eu-repo/semantics/openAccess2022-10-06T12:34:51Zoai:ojs.revista.spdv.com.pt:article/335Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:51.060085Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY
ANGIOSSARCOMA DA MAMA APÓS RADIOTERAPIA
title BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY
spellingShingle BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY
Ramos, Leonor
Breast neoplasms
Hemangiosarcoma
Radiotherapy
Angiossarcoma
Neoplasias da mama
Radioterapia
title_short BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY
title_full BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY
title_fullStr BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY
title_full_unstemmed BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY
title_sort BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY
author Ramos, Leonor
author_facet Ramos, Leonor
Simões, Pedro
Gouveia, Miguel
Pereira, Neide
Cardoso, José Carlos
Figueiredo, Américo
author_role author
author2 Simões, Pedro
Gouveia, Miguel
Pereira, Neide
Cardoso, José Carlos
Figueiredo, Américo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ramos, Leonor
Simões, Pedro
Gouveia, Miguel
Pereira, Neide
Cardoso, José Carlos
Figueiredo, Américo
dc.subject.por.fl_str_mv Breast neoplasms
Hemangiosarcoma
Radiotherapy
Angiossarcoma
Neoplasias da mama
Radioterapia
topic Breast neoplasms
Hemangiosarcoma
Radiotherapy
Angiossarcoma
Neoplasias da mama
Radioterapia
description Breast angiosarcoma is a rare tumor that can be divided in 3 groups: primary, secondary to chronic lymphoedema and secondary to radiotherapy (RT). It has a poor prognosis and a bad response to surgery and chemotherapy (QT). A female patient was observed with a very indurated erythematous-violaceous plaque, with an ecchymotic halo that occupied the right breast, and was evolving for 8 months. The patient had history of breast cancer, treated with surgery (tumourectomy) and local RT 5 years before. The incisional biopsy showed a vascular proliferation, arranged in nodules but also with diffuse growing, with cytological atypia and strong expression of CD31, CD34 and factor VIII, consistent with post-RT angiosarcoma. The patient begun RT and QT, but had no significant clinical response. She is now waiting for approval to begin pazopanib.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-13T00:00:00Z
dc.type.driver.fl_str_mv journal article
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dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.72.4.335
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url https://doi.org/10.29021/spdv.72.4.335
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dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/335
https://doi.org/10.29021/spdv.72.4.335
https://revista.spdv.com.pt/index.php/spdv/article/view/335/308
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 72 No 4 (2014): Outubro - Dezembro; 593-597
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 72 n. 4 (2014): Outubro - Dezembro; 593-597
2182-2409
2182-2395
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