BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.72.4.335 |
Resumo: | Breast angiosarcoma is a rare tumor that can be divided in 3 groups: primary, secondary to chronic lymphoedema and secondary to radiotherapy (RT). It has a poor prognosis and a bad response to surgery and chemotherapy (QT). A female patient was observed with a very indurated erythematous-violaceous plaque, with an ecchymotic halo that occupied the right breast, and was evolving for 8 months. The patient had history of breast cancer, treated with surgery (tumourectomy) and local RT 5 years before. The incisional biopsy showed a vascular proliferation, arranged in nodules but also with diffuse growing, with cytological atypia and strong expression of CD31, CD34 and factor VIII, consistent with post-RT angiosarcoma. The patient begun RT and QT, but had no significant clinical response. She is now waiting for approval to begin pazopanib. |
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BREAST ANGIOSSARCOMA AFTER RADIOTHERAPYANGIOSSARCOMA DA MAMA APÓS RADIOTERAPIABreast neoplasmsHemangiosarcomaRadiotherapyAngiossarcomaNeoplasias da mamaRadioterapiaBreast angiosarcoma is a rare tumor that can be divided in 3 groups: primary, secondary to chronic lymphoedema and secondary to radiotherapy (RT). It has a poor prognosis and a bad response to surgery and chemotherapy (QT). A female patient was observed with a very indurated erythematous-violaceous plaque, with an ecchymotic halo that occupied the right breast, and was evolving for 8 months. The patient had history of breast cancer, treated with surgery (tumourectomy) and local RT 5 years before. The incisional biopsy showed a vascular proliferation, arranged in nodules but also with diffuse growing, with cytological atypia and strong expression of CD31, CD34 and factor VIII, consistent with post-RT angiosarcoma. The patient begun RT and QT, but had no significant clinical response. She is now waiting for approval to begin pazopanib.O angiossarcoma da mama é uma neoplasia pouco frequente que se pode classificar em 3 grupos: primário, secundário a linfedema crónico e secundário a radioterapia (RT). Tem por norma mau prognóstico, com má resposta a cirurgia e quimioterapia (QT). Uma doente do sexo feminino foi observada com placa de coloração eritematoviolácea, com halo equimótico periférico, de consistência muito endurecida, que ocupava a mama direita com 8 meses de evolução. Havia história prévia de carcinoma ductal invasivo da mama direita, submetido a tumorectomia e RT local adjuvante 5 anos antes. A biópsia incisional revelou proliferação vascular nodular e difusa, com atipia citológica marcada e expressão intensa de CD31, CD34 e factor VIII, compatível com angiossarcoma pós-RT. A doente foi encaminhada para a Unidade de Tumores Ósseos e de Tecidos moles, tendo iniciado RT e QT neo-adjuvante, sem resposta significativa. Está neste momento a aguardar tratamento com pazopanib.Sociedade Portuguesa de Dermatologia e Venereologia2015-04-13T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.72.4.335oai:ojs.revista.spdv.com.pt:article/335Journal of the Portuguese Society of Dermatology and Venereology; Vol 72 No 4 (2014): Outubro - Dezembro; 593-597Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 72 n. 4 (2014): Outubro - Dezembro; 593-5972182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/335https://doi.org/10.29021/spdv.72.4.335https://revista.spdv.com.pt/index.php/spdv/article/view/335/308Ramos, LeonorSimões, PedroGouveia, MiguelPereira, NeideCardoso, José CarlosFigueiredo, Américoinfo:eu-repo/semantics/openAccess2022-10-06T12:34:51Zoai:ojs.revista.spdv.com.pt:article/335Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:51.060085Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY ANGIOSSARCOMA DA MAMA APÓS RADIOTERAPIA |
title |
BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY |
spellingShingle |
BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY Ramos, Leonor Breast neoplasms Hemangiosarcoma Radiotherapy Angiossarcoma Neoplasias da mama Radioterapia |
title_short |
BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY |
title_full |
BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY |
title_fullStr |
BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY |
title_full_unstemmed |
BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY |
title_sort |
BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY |
author |
Ramos, Leonor |
author_facet |
Ramos, Leonor Simões, Pedro Gouveia, Miguel Pereira, Neide Cardoso, José Carlos Figueiredo, Américo |
author_role |
author |
author2 |
Simões, Pedro Gouveia, Miguel Pereira, Neide Cardoso, José Carlos Figueiredo, Américo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ramos, Leonor Simões, Pedro Gouveia, Miguel Pereira, Neide Cardoso, José Carlos Figueiredo, Américo |
dc.subject.por.fl_str_mv |
Breast neoplasms Hemangiosarcoma Radiotherapy Angiossarcoma Neoplasias da mama Radioterapia |
topic |
Breast neoplasms Hemangiosarcoma Radiotherapy Angiossarcoma Neoplasias da mama Radioterapia |
description |
Breast angiosarcoma is a rare tumor that can be divided in 3 groups: primary, secondary to chronic lymphoedema and secondary to radiotherapy (RT). It has a poor prognosis and a bad response to surgery and chemotherapy (QT). A female patient was observed with a very indurated erythematous-violaceous plaque, with an ecchymotic halo that occupied the right breast, and was evolving for 8 months. The patient had history of breast cancer, treated with surgery (tumourectomy) and local RT 5 years before. The incisional biopsy showed a vascular proliferation, arranged in nodules but also with diffuse growing, with cytological atypia and strong expression of CD31, CD34 and factor VIII, consistent with post-RT angiosarcoma. The patient begun RT and QT, but had no significant clinical response. She is now waiting for approval to begin pazopanib. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-13T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.72.4.335 oai:ojs.revista.spdv.com.pt:article/335 |
url |
https://doi.org/10.29021/spdv.72.4.335 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/335 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/335 https://doi.org/10.29021/spdv.72.4.335 https://revista.spdv.com.pt/index.php/spdv/article/view/335/308 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 72 No 4 (2014): Outubro - Dezembro; 593-597 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 72 n. 4 (2014): Outubro - Dezembro; 593-597 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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