The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas

Detalhes bibliográficos
Autor(a) principal: Bouça, Bruno
Data de Publicação: 2022
Outros Autores: Bogalho, Paula, Rizzo, Manfredi, Silva-Nunes, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/133483
Resumo: Funding: This work was supported by the project grant DSAIPA/DS/0117/2020 supported by Fundação para a Ciência e a Tecnologia, Portugal; and by the project grant NeproMD/ISEL/2020 financed by Instituto Politécnico de Lisboa
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spelling The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and ParagangliomasAn UpdateEpigeneticsMetabolomeMicroRNAParagangliomaPheochromocytomaEndocrinology, Diabetes and MetabolismBiochemistryMolecular BiologySDG 3 - Good Health and Well-beingFunding: This work was supported by the project grant DSAIPA/DS/0117/2020 supported by Fundação para a Ciência e a Tecnologia, Portugal; and by the project grant NeproMD/ISEL/2020 financed by Instituto Politécnico de LisboaPheochromocytoma and paragangliomas (PPGL) are rare neuroendocrine tumors. In some patients they exhibit malignant behavior characterized by the presence of metastases, limiting treatment options and survival rates. Therapeutic options are limited to surgery, localized radiotherapy, and a few systemic therapies. However, in several recent studies, non-coding RNA molecules are gaining increasing attention as markers of malignancy for PPGL. The understanding of PPGL development molecular mechanisms has improved in the last years, with some of the epigenetic regulatory mechanisms such as DNA and histones methylation, being better understood than RNA-based mechanisms. Metabolome deregulation in PPGL, with increased synthesis of molecules that facilitated tumor growth, results from the activation of hypoxia signaling pathways, affecting tumorigenesis. In addition, the assessment of these metabolites can be useful for the management of these tumors. This review summarizes recent discoveries linking metabolome and non-coding RNA to PPGL and their relevance for diagnosis and therapeutics.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBouça, BrunoBogalho, PaulaRizzo, ManfrediSilva-Nunes, José2022-02-23T23:17:36Z2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/133483eng2218-1989PURE: 41735637https://doi.org/10.3390/metabo12020131info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:12:05Zoai:run.unl.pt:10362/133483Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:48.620534Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas
An Update
title The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas
spellingShingle The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas
Bouça, Bruno
Epigenetics
Metabolome
MicroRNA
Paraganglioma
Pheochromocytoma
Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
SDG 3 - Good Health and Well-being
title_short The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas
title_full The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas
title_fullStr The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas
title_full_unstemmed The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas
title_sort The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas
author Bouça, Bruno
author_facet Bouça, Bruno
Bogalho, Paula
Rizzo, Manfredi
Silva-Nunes, José
author_role author
author2 Bogalho, Paula
Rizzo, Manfredi
Silva-Nunes, José
author2_role author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Bouça, Bruno
Bogalho, Paula
Rizzo, Manfredi
Silva-Nunes, José
dc.subject.por.fl_str_mv Epigenetics
Metabolome
MicroRNA
Paraganglioma
Pheochromocytoma
Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
SDG 3 - Good Health and Well-being
topic Epigenetics
Metabolome
MicroRNA
Paraganglioma
Pheochromocytoma
Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Biology
SDG 3 - Good Health and Well-being
description Funding: This work was supported by the project grant DSAIPA/DS/0117/2020 supported by Fundação para a Ciência e a Tecnologia, Portugal; and by the project grant NeproMD/ISEL/2020 financed by Instituto Politécnico de Lisboa
publishDate 2022
dc.date.none.fl_str_mv 2022-02-23T23:17:36Z
2022-02
2022-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/133483
url http://hdl.handle.net/10362/133483
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2218-1989
PURE: 41735637
https://doi.org/10.3390/metabo12020131
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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