The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/14348 |
Resumo: | Pheochromocytoma and paragangliomas (PPGL) are rare neuroendocrine tumors. In some patients they exhibit malignant behavior characterized by the presence of metastases, limiting treatment options and survival rates. Therapeutic options are limited to surgery, localized radiotherapy, and a few systemic therapies. However, in several recent studies, non-coding RNA molecules are gaining increasing attention as markers of malignancy for PPGL. The understanding of PPGL development molecular mechanisms has improved in the last years, with some of the epigenetic regulatory mechanisms such as DNA and histones methylation, being better understood than RNA-based mechanisms. Metabolome deregulation in PPGL, with increased synthesis of molecules that facilitated tumor growth, results from the activation of hypoxia signaling pathways, affecting tumorigenesis. In addition, the assessment of these metabolites can be useful for the management of these tumors. This review summarizes recent discoveries linking metabolome and non-coding RNA to PPGL and their relevance for diagnosis and therapeutics. |
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The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an updatePheochromocytomaParagangliomaMetabolomeMicroRNAEpigeneticsPheochromocytoma and paragangliomas (PPGL) are rare neuroendocrine tumors. In some patients they exhibit malignant behavior characterized by the presence of metastases, limiting treatment options and survival rates. Therapeutic options are limited to surgery, localized radiotherapy, and a few systemic therapies. However, in several recent studies, non-coding RNA molecules are gaining increasing attention as markers of malignancy for PPGL. The understanding of PPGL development molecular mechanisms has improved in the last years, with some of the epigenetic regulatory mechanisms such as DNA and histones methylation, being better understood than RNA-based mechanisms. Metabolome deregulation in PPGL, with increased synthesis of molecules that facilitated tumor growth, results from the activation of hypoxia signaling pathways, affecting tumorigenesis. In addition, the assessment of these metabolites can be useful for the management of these tumors. This review summarizes recent discoveries linking metabolome and non-coding RNA to PPGL and their relevance for diagnosis and therapeutics.MDPIRCIPLBouça, BrunoBogalho, PaulaRizzo, ManfrediSilva-Nunes, José2022-02-28T12:50:12Z2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14348engBouça B, Bogalho P, Rizzo M, Silva-Nunes J. The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update. Metabolites. 2022;12(2):131.10.3390/metabo12020131info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:10:23Zoai:repositorio.ipl.pt:10400.21/14348Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:10.095385Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update |
title |
The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update |
spellingShingle |
The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update Bouça, Bruno Pheochromocytoma Paraganglioma Metabolome MicroRNA Epigenetics |
title_short |
The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update |
title_full |
The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update |
title_fullStr |
The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update |
title_full_unstemmed |
The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update |
title_sort |
The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update |
author |
Bouça, Bruno |
author_facet |
Bouça, Bruno Bogalho, Paula Rizzo, Manfredi Silva-Nunes, José |
author_role |
author |
author2 |
Bogalho, Paula Rizzo, Manfredi Silva-Nunes, José |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Bouça, Bruno Bogalho, Paula Rizzo, Manfredi Silva-Nunes, José |
dc.subject.por.fl_str_mv |
Pheochromocytoma Paraganglioma Metabolome MicroRNA Epigenetics |
topic |
Pheochromocytoma Paraganglioma Metabolome MicroRNA Epigenetics |
description |
Pheochromocytoma and paragangliomas (PPGL) are rare neuroendocrine tumors. In some patients they exhibit malignant behavior characterized by the presence of metastases, limiting treatment options and survival rates. Therapeutic options are limited to surgery, localized radiotherapy, and a few systemic therapies. However, in several recent studies, non-coding RNA molecules are gaining increasing attention as markers of malignancy for PPGL. The understanding of PPGL development molecular mechanisms has improved in the last years, with some of the epigenetic regulatory mechanisms such as DNA and histones methylation, being better understood than RNA-based mechanisms. Metabolome deregulation in PPGL, with increased synthesis of molecules that facilitated tumor growth, results from the activation of hypoxia signaling pathways, affecting tumorigenesis. In addition, the assessment of these metabolites can be useful for the management of these tumors. This review summarizes recent discoveries linking metabolome and non-coding RNA to PPGL and their relevance for diagnosis and therapeutics. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-28T12:50:12Z 2022-02 2022-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/14348 |
url |
http://hdl.handle.net/10400.21/14348 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bouça B, Bogalho P, Rizzo M, Silva-Nunes J. The role of the metabolome and non-coding RNA on pheochromocytomas and paragangliomas: an update. Metabolites. 2022;12(2):131. 10.3390/metabo12020131 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133493774516224 |