Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic

Detalhes bibliográficos
Autor(a) principal: Rito, Teresa S
Data de Publicação: 2020
Outros Autores: Richards, Martin B., Pala, Maria, Correia-Neves, M, Soares, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/68062
Resumo: Supplementary Material available at: https://www.mdpi.com/2076-2607/8/11/1678/s1
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spelling Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemicphylogeographyphylogenomicsmolecular epidemiologytravel bansintercontinental foundersSARS-COV-2 lineagesCOVID-19Ciências Médicas::Ciências da SaúdeScience & TechnologySupplementary Material available at: https://www.mdpi.com/2076-2607/8/11/1678/s1The novel coronavirus SARS-CoV-2 emerged from a zoonotic transmission in China towards the end of 2019, rapidly leading to a global pandemic on a scale not seen for a century. In order to cast fresh light on the spread of the virus and on the effectiveness of the containment measures adopted globally, we used 26,869 SARS-CoV-2 genomes to build a phylogeny with 20,247 mutation events and adopted a phylogeographic approach. We confirmed that the phylogeny pinpoints China as the origin of the pandemic with major founders worldwide, mainly during January 2020. However, a single specific East Asian founder underwent massive radiation in Europe and became the main actor of the subsequent spread worldwide during March 2020. This lineage accounts for the great majority of cases detected globally and even spread back to the source in East Asia. Despite an East Asian source, therefore, the global pandemic was mainly fueled by its expansion across and out of Europe. It seems likely that travel bans established throughout the world in the second half of March helped to decrease the number of intercontinental exchanges, particularly from mainland China, but were less effective between Europe and North America where exchanges in both directions are visible up to April, long after bans were imposed.This work was supported by strategic project ICVS/3B’s (UID/Multi/50025), financed by Fundação para a Ciência e Tecnologia/MCTES through national funds (PIDDAC) to Teresa Rito. Martin B. Richards and Maria Pala received support from a Leverhulme Doctoral Scholarship program. This work was partially supported by project NORTE-01-0145-FEDER000009) by Norte Portugal Regional Operational Program (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by “Contrato-Programa” UIDB/04050/2020 funded by Portuguese national funds through the Fundação para a Ciência e Tecnologia to Pedro A. Soares.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoRito, Teresa SRichards, Martin B.Pala, MariaCorreia-Neves, MSoares, Pedro2020-10-292020-10-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/68062engRito, T.; Richards, M.B.; Pala, M.; Correia-Neves, M.; Soares, P.A. Phylogeography of 27,000 SARS-CoV-2 Genomes: Europe as the Major Source of the COVID-19 Pandemic. Microorganisms 2020, 8, 1678. DOI: 10.3390/microorganisms81116782076-260710.3390/microorganisms8111678https://www.mdpi.com/2076-2607/8/11/1678info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:35:07Zoai:repositorium.sdum.uminho.pt:1822/68062Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:30:56.130606Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic
title Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic
spellingShingle Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic
Rito, Teresa S
phylogeography
phylogenomics
molecular epidemiology
travel bans
intercontinental founders
SARS-COV-2 lineages
COVID-19
Ciências Médicas::Ciências da Saúde
Science & Technology
title_short Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic
title_full Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic
title_fullStr Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic
title_full_unstemmed Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic
title_sort Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the COVID-19 pandemic
author Rito, Teresa S
author_facet Rito, Teresa S
Richards, Martin B.
Pala, Maria
Correia-Neves, M
Soares, Pedro
author_role author
author2 Richards, Martin B.
Pala, Maria
Correia-Neves, M
Soares, Pedro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rito, Teresa S
Richards, Martin B.
Pala, Maria
Correia-Neves, M
Soares, Pedro
dc.subject.por.fl_str_mv phylogeography
phylogenomics
molecular epidemiology
travel bans
intercontinental founders
SARS-COV-2 lineages
COVID-19
Ciências Médicas::Ciências da Saúde
Science & Technology
topic phylogeography
phylogenomics
molecular epidemiology
travel bans
intercontinental founders
SARS-COV-2 lineages
COVID-19
Ciências Médicas::Ciências da Saúde
Science & Technology
description Supplementary Material available at: https://www.mdpi.com/2076-2607/8/11/1678/s1
publishDate 2020
dc.date.none.fl_str_mv 2020-10-29
2020-10-29T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/68062
url http://hdl.handle.net/1822/68062
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rito, T.; Richards, M.B.; Pala, M.; Correia-Neves, M.; Soares, P.A. Phylogeography of 27,000 SARS-CoV-2 Genomes: Europe as the Major Source of the COVID-19 Pandemic. Microorganisms 2020, 8, 1678. DOI: 10.3390/microorganisms8111678
2076-2607
10.3390/microorganisms8111678
https://www.mdpi.com/2076-2607/8/11/1678
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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