Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology

Detalhes bibliográficos
Autor(a) principal: Aroso, Ivo Manuel Ascensão
Data de Publicação: 2015
Outros Autores: Craveiro, Rita, Rocha, Ângelo, Dionisio, Madalena, Barreiros, Susana, Reis, R. L., Paiva, Alexandre, Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/38103
Resumo: Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.
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spelling Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technologyBiodegradable polymersDrug delivery systemsIbuprofenSupercritical carbon dioxideTherapeutic deep eutectic solventsCiências Médicas::Biotecnologia MédicaScience & TechnologyDeep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.Projects ENIGMA - PTDC/EQU-EPR/121491/2010, PTDC/QUI-QUI/119210/2010, PTDC/EQU-EQU/122106/2010, PEst-C/EQB/LA0006/2013 from the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n° REGPOT - CT2012-316331-POLARIS and from Project “Novel smart and biomimetic materials for innovative regenerative medicine approaches (Ref.: RL1 - ABMR - NORTE-01-0124-FEDER-000016)” co-financed by North Portugal Regional Operational Programme (ON.2–O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF).ElsevierUniversidade do MinhoAroso, Ivo Manuel AscensãoCraveiro, RitaRocha, ÂngeloDionisio, MadalenaBarreiros, SusanaReis, R. L.Paiva, AlexandreDuarte, Ana Rita C.2015-082015-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/38103engAroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology, International Journal of Pharmaceutics, Vol. 492, Issue 1-2, pp. 73-79, doi:10.1016/j.ijpharm.2015.06.038, 20150378-517310.1016/j.ijpharm.2015.06.03826142248http://www.sciencedirect.com/science/article/pii/S0378517315300053info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T05:55:37Zoai:repositorium.sdum.uminho.pt:1822/38103Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T05:55:37Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
title Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
spellingShingle Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
Aroso, Ivo Manuel Ascensão
Biodegradable polymers
Drug delivery systems
Ibuprofen
Supercritical carbon dioxide
Therapeutic deep eutectic solvents
Ciências Médicas::Biotecnologia Médica
Science & Technology
title_short Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
title_full Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
title_fullStr Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
title_full_unstemmed Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
title_sort Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
author Aroso, Ivo Manuel Ascensão
author_facet Aroso, Ivo Manuel Ascensão
Craveiro, Rita
Rocha, Ângelo
Dionisio, Madalena
Barreiros, Susana
Reis, R. L.
Paiva, Alexandre
Duarte, Ana Rita C.
author_role author
author2 Craveiro, Rita
Rocha, Ângelo
Dionisio, Madalena
Barreiros, Susana
Reis, R. L.
Paiva, Alexandre
Duarte, Ana Rita C.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Aroso, Ivo Manuel Ascensão
Craveiro, Rita
Rocha, Ângelo
Dionisio, Madalena
Barreiros, Susana
Reis, R. L.
Paiva, Alexandre
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Biodegradable polymers
Drug delivery systems
Ibuprofen
Supercritical carbon dioxide
Therapeutic deep eutectic solvents
Ciências Médicas::Biotecnologia Médica
Science & Technology
topic Biodegradable polymers
Drug delivery systems
Ibuprofen
Supercritical carbon dioxide
Therapeutic deep eutectic solvents
Ciências Médicas::Biotecnologia Médica
Science & Technology
description Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
2015-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/38103
url http://hdl.handle.net/1822/38103
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Aroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology, International Journal of Pharmaceutics, Vol. 492, Issue 1-2, pp. 73-79, doi:10.1016/j.ijpharm.2015.06.038, 2015
0378-5173
10.1016/j.ijpharm.2015.06.038
26142248
http://www.sciencedirect.com/science/article/pii/S0378517315300053
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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