Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/38099 |
Resumo: | Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug, and menthol was synthesized. A controlled drug delivery system was developed by impregnating a starch:poly-ε-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt %), by supercritical fluid sintering at 20 MPa and 50 oC. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT) and drug release studies were carried out at 37ºC, in phosphate buffered saline (PBS). The results obtained have shown that the solubility profiles of ibuprofen in PBS are similar in powder form and in THEDES. Nonetheless, when incorporated in a polymeric matrix, ibuprofen in the THEDES form has a faster release profile. The drug release in this system is mostly governed by diffusion, as expected due to the hydrophobic nature of the polymer used as carrier. The outcomes of this work demonstrate the improved performance of THEDES based pharmaceutical formulations and the feasibility to couple with green production technologies to develop enhanced biomaterials for therapeutic applications. |
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Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systemsDrug deliveryGreen chemistryIbuprofenPolycaprolactoneStarchSupercritical fluidsTherapeutic deep eutectic solventsBiomaterialBiomedical engineeringMaterials ScienceEngenharia e Tecnologia::Biotecnologia IndustrialScience & TechnologyDeep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug, and menthol was synthesized. A controlled drug delivery system was developed by impregnating a starch:poly-ε-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt %), by supercritical fluid sintering at 20 MPa and 50 oC. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT) and drug release studies were carried out at 37ºC, in phosphate buffered saline (PBS). The results obtained have shown that the solubility profiles of ibuprofen in PBS are similar in powder form and in THEDES. Nonetheless, when incorporated in a polymeric matrix, ibuprofen in the THEDES form has a faster release profile. The drug release in this system is mostly governed by diffusion, as expected due to the hydrophobic nature of the polymer used as carrier. The outcomes of this work demonstrate the improved performance of THEDES based pharmaceutical formulations and the feasibility to couple with green production technologies to develop enhanced biomaterials for therapeutic applications. Mary Ann LiebertUniversidade do MinhoAroso, Ivo Manuel AscensãoCraveiro, R.Rocha, Â.Dionisio, M.Barreiros, S.Reis, R. L.Paiva, AlexandreDuarte, Ana Rita C.2015-092015-09-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/38099engAroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems, Tissue Engineering Part A, Vol. 21, Issue S1, pp. S-1-S-413, doi:10.1089/ten.tea.2015.5000.abstracts, 20151937-3341http://online.liebertpub.com/doi/pdfplus/10.1089/ten.tea.2015.5000.abstractsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T04:15:30Zoai:repositorium.sdum.uminho.pt:1822/38099Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T04:15:30Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems |
title |
Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems |
spellingShingle |
Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems Aroso, Ivo Manuel Ascensão Drug delivery Green chemistry Ibuprofen Polycaprolactone Starch Supercritical fluids Therapeutic deep eutectic solvents Biomaterial Biomedical engineering Materials Science Engenharia e Tecnologia::Biotecnologia Industrial Science & Technology |
title_short |
Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems |
title_full |
Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems |
title_fullStr |
Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems |
title_full_unstemmed |
Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems |
title_sort |
Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems |
author |
Aroso, Ivo Manuel Ascensão |
author_facet |
Aroso, Ivo Manuel Ascensão Craveiro, R. Rocha, Â. Dionisio, M. Barreiros, S. Reis, R. L. Paiva, Alexandre Duarte, Ana Rita C. |
author_role |
author |
author2 |
Craveiro, R. Rocha, Â. Dionisio, M. Barreiros, S. Reis, R. L. Paiva, Alexandre Duarte, Ana Rita C. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Aroso, Ivo Manuel Ascensão Craveiro, R. Rocha, Â. Dionisio, M. Barreiros, S. Reis, R. L. Paiva, Alexandre Duarte, Ana Rita C. |
dc.subject.por.fl_str_mv |
Drug delivery Green chemistry Ibuprofen Polycaprolactone Starch Supercritical fluids Therapeutic deep eutectic solvents Biomaterial Biomedical engineering Materials Science Engenharia e Tecnologia::Biotecnologia Industrial Science & Technology |
topic |
Drug delivery Green chemistry Ibuprofen Polycaprolactone Starch Supercritical fluids Therapeutic deep eutectic solvents Biomaterial Biomedical engineering Materials Science Engenharia e Tecnologia::Biotecnologia Industrial Science & Technology |
description |
Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug, and menthol was synthesized. A controlled drug delivery system was developed by impregnating a starch:poly-ε-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt %), by supercritical fluid sintering at 20 MPa and 50 oC. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT) and drug release studies were carried out at 37ºC, in phosphate buffered saline (PBS). The results obtained have shown that the solubility profiles of ibuprofen in PBS are similar in powder form and in THEDES. Nonetheless, when incorporated in a polymeric matrix, ibuprofen in the THEDES form has a faster release profile. The drug release in this system is mostly governed by diffusion, as expected due to the hydrophobic nature of the polymer used as carrier. The outcomes of this work demonstrate the improved performance of THEDES based pharmaceutical formulations and the feasibility to couple with green production technologies to develop enhanced biomaterials for therapeutic applications. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09 2015-09-01T00:00:00Z |
dc.type.driver.fl_str_mv |
conference object |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/38099 |
url |
http://hdl.handle.net/1822/38099 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Aroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems, Tissue Engineering Part A, Vol. 21, Issue S1, pp. S-1-S-413, doi:10.1089/ten.tea.2015.5000.abstracts, 2015 1937-3341 http://online.liebertpub.com/doi/pdfplus/10.1089/ten.tea.2015.5000.abstracts |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Mary Ann Liebert |
publisher.none.fl_str_mv |
Mary Ann Liebert |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817544258435940352 |