Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems

Detalhes bibliográficos
Autor(a) principal: Aroso, Ivo Manuel Ascensão
Data de Publicação: 2015
Outros Autores: Craveiro, R., Rocha, Â., Dionisio, M., Barreiros, S., Reis, R. L., Paiva, Alexandre, Duarte, Ana Rita C.
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/38099
Resumo: Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug, and menthol was synthesized. A controlled drug delivery system was developed by impregnating a starch:poly-ε-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt %), by supercritical fluid sintering at 20 MPa and 50 oC. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT) and drug release studies were carried out at 37ºC, in phosphate buffered saline (PBS). The results obtained have shown that the solubility profiles of ibuprofen in PBS are similar in powder form and in THEDES. Nonetheless, when incorporated in a polymeric matrix, ibuprofen in the THEDES form has a faster release profile. The drug release in this system is mostly governed by diffusion, as expected due to the hydrophobic nature of the polymer used as carrier. The outcomes of this work demonstrate the improved performance of THEDES based pharmaceutical formulations and the feasibility to couple with green production technologies to develop enhanced biomaterials for therapeutic applications.    
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spelling Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systemsDrug deliveryGreen chemistryIbuprofenPolycaprolactoneStarchSupercritical fluidsTherapeutic deep eutectic solventsBiomaterialBiomedical engineeringMaterials ScienceEngenharia e Tecnologia::Biotecnologia IndustrialScience & TechnologyDeep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug, and menthol was synthesized. A controlled drug delivery system was developed by impregnating a starch:poly-ε-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt %), by supercritical fluid sintering at 20 MPa and 50 oC. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT) and drug release studies were carried out at 37ºC, in phosphate buffered saline (PBS). The results obtained have shown that the solubility profiles of ibuprofen in PBS are similar in powder form and in THEDES. Nonetheless, when incorporated in a polymeric matrix, ibuprofen in the THEDES form has a faster release profile. The drug release in this system is mostly governed by diffusion, as expected due to the hydrophobic nature of the polymer used as carrier. The outcomes of this work demonstrate the improved performance of THEDES based pharmaceutical formulations and the feasibility to couple with green production technologies to develop enhanced biomaterials for therapeutic applications.    Mary Ann LiebertUniversidade do MinhoAroso, Ivo Manuel AscensãoCraveiro, R.Rocha, Â.Dionisio, M.Barreiros, S.Reis, R. L.Paiva, AlexandreDuarte, Ana Rita C.2015-092015-09-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/38099engAroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems, Tissue Engineering Part A, Vol. 21, Issue S1, pp. S-1-S-413, doi:10.1089/ten.tea.2015.5000.abstracts, 20151937-3341http://online.liebertpub.com/doi/pdfplus/10.1089/ten.tea.2015.5000.abstractsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T04:15:30Zoai:repositorium.sdum.uminho.pt:1822/38099Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T04:15:30Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems
title Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems
spellingShingle Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems
Aroso, Ivo Manuel Ascensão
Drug delivery
Green chemistry
Ibuprofen
Polycaprolactone
Starch
Supercritical fluids
Therapeutic deep eutectic solvents
Biomaterial
Biomedical engineering
Materials Science
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
title_short Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems
title_full Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems
title_fullStr Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems
title_full_unstemmed Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems
title_sort Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems
author Aroso, Ivo Manuel Ascensão
author_facet Aroso, Ivo Manuel Ascensão
Craveiro, R.
Rocha, Â.
Dionisio, M.
Barreiros, S.
Reis, R. L.
Paiva, Alexandre
Duarte, Ana Rita C.
author_role author
author2 Craveiro, R.
Rocha, Â.
Dionisio, M.
Barreiros, S.
Reis, R. L.
Paiva, Alexandre
Duarte, Ana Rita C.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Aroso, Ivo Manuel Ascensão
Craveiro, R.
Rocha, Â.
Dionisio, M.
Barreiros, S.
Reis, R. L.
Paiva, Alexandre
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Drug delivery
Green chemistry
Ibuprofen
Polycaprolactone
Starch
Supercritical fluids
Therapeutic deep eutectic solvents
Biomaterial
Biomedical engineering
Materials Science
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
topic Drug delivery
Green chemistry
Ibuprofen
Polycaprolactone
Starch
Supercritical fluids
Therapeutic deep eutectic solvents
Biomaterial
Biomedical engineering
Materials Science
Engenharia e Tecnologia::Biotecnologia Industrial
Science & Technology
description Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug, and menthol was synthesized. A controlled drug delivery system was developed by impregnating a starch:poly-ε-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt %), by supercritical fluid sintering at 20 MPa and 50 oC. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT) and drug release studies were carried out at 37ºC, in phosphate buffered saline (PBS). The results obtained have shown that the solubility profiles of ibuprofen in PBS are similar in powder form and in THEDES. Nonetheless, when incorporated in a polymeric matrix, ibuprofen in the THEDES form has a faster release profile. The drug release in this system is mostly governed by diffusion, as expected due to the hydrophobic nature of the polymer used as carrier. The outcomes of this work demonstrate the improved performance of THEDES based pharmaceutical formulations and the feasibility to couple with green production technologies to develop enhanced biomaterials for therapeutic applications.    
publishDate 2015
dc.date.none.fl_str_mv 2015-09
2015-09-01T00:00:00Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/38099
url http://hdl.handle.net/1822/38099
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Aroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Coupling THEDES - therapeutic deep eutectic solvents and supercritical fluid technology for the development of controlled delivery systems, Tissue Engineering Part A, Vol. 21, Issue S1, pp. S-1-S-413, doi:10.1089/ten.tea.2015.5000.abstracts, 2015
1937-3341
http://online.liebertpub.com/doi/pdfplus/10.1089/ten.tea.2015.5000.abstracts
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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