First case of confirmed congenital Zika syndrome in continental Africa

• Autor(a) principal: Sassetti, M.
• Data de Publicação: 2018
• Outros Autores: Zé-Zé, L., Franco, J., Cunha, J.D., Gomes, A., Tomé, A., Alves, M.J.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.18/5843
• topic: Zika Virus; Angola; Congenital Zika Syndrome; Microcephaly; Portugal; Infecções Sistémicas e Zoonoses

Background: Zika virus has been responsible for recent outbreaks in the western hemisphere with known neurological complications such as microcephaly. This complication has not been previously documented in continental Africa. Methods: Neurological evaluation of the newborn was performed after birth, at one and two months of age. The mother and the newborn sera samples were tested by immunofluorescent assay (IFA; immunoglobulin G [IgG] and IgM) for Zika virus and the presence of Zika virus ribonucleic acid (RNA) was checked by qualitative real-time reverse transcription polymerase chain reaction (RT-PCR) in placenta, blood and urine samples. Results: We report on a newborn, born in Portugal, with microcephaly with confirmed congenital Zika virus infection (Asian lineage) imported from Angola with typical clinical and imaging findings. Conclusions: To our knowledge this is the first report that shows the circulation of the Asian lineage in Angola and the first report of a congenital Zika syndrome in continental Africa.