Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/150477 |
Resumo: | Funding The study received support from the American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritisdata from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registriesArthritisArthritis, PsoriaticAutoimmunityCovid-19Spondylitis, AnkylosingSDG 3 - Good Health and Well-beingFunding The study received support from the American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR).OBJECTIVES: To investigate factors associated with severe COVID-19 in people with psoriasis (PsO), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). METHODS: Demographic data, clinical characteristics and COVID-19 outcome severity of adults with PsO, PsA and axSpA were obtained from two international physician-reported registries. A three-point ordinal COVID-19 severity scale was defined: no hospitalisation, hospitalisation (and no death) and death. ORs were estimated using multivariable ordinal logistic regression. RESULTS: Of 5045 cases, 18.3% had PsO, 45.5% PsA and 36.3% axSpA. Most (83.6%) were not hospitalised, 14.6% were hospitalised and 1.8% died. Older age was non-linearly associated with COVID-19 severity. Male sex (OR 1.54, 95% CI 1.30 to 1.83), cardiovascular, respiratory, renal, metabolic and cancer comorbidities (ORs 1.25-2.89), moderate/high disease activity and/or glucocorticoid use (ORs 1.39-2.23, vs remission/low disease activity and no glucocorticoids) were associated with increased odds of severe COVID-19. Later pandemic time periods (ORs 0.42-0.52, vs until 15 June 2020), PsO (OR 0.49, 95% CI 0.37 to 0.65, vs PsA) and baseline exposure to TNFi, IL17i and IL-23i/IL-12+23i (OR 0.57, 95% CI 0.44 to 0.73; OR 0.62, 95% CI 0.45 to 0.87; OR 0.67, 95% CI 0.45 to 0.98; respectively; vs no disease-modifying antirheumatic drug) were associated with reduced odds of severe COVID-19. CONCLUSION: Older age, male sex, comorbidity burden, higher disease activity and glucocorticoid intake were associated with more severe COVID-19. Later pandemic time periods, PsO and exposure to TNFi, IL17i and IL-23i/IL-12+23i were associated with less severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with PsO, PsA and axSpA during COVID-19 waves or similar future respiratory pandemics.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMachado, Pedro MSchäfer, MartinMahil, Satveer KLiew, JeanGossec, LaureDand, NickPfeil, AlexanderStrangfeld, AnjaRegierer, Anne ConstanzeFautrel, BrunoAlonso, Carla GimenaSaad, Carla G SGriffiths, Christopher E MLomater, ClaudiaMiceli-Richard, CorinneWendling, DanielAlpizar Rodriguez, DeshireWiek, DieterMateus, Elsa FSirotich, EmilySoriano, Enrique RRibeiro, Francinne MachadoOmura, FelipeRajão Martins, FredericoSantos, HelenaDau, JonathanBarker, Jonathan NHausmann, JonathanHyrich, Kimme LGensler, LianneSilva, LigiaJacobsohn, LindsayCarmona, LoretoPinheiro, Marcelo MZelaya, Marcos DavidSeverina, María de Los ÁngelesYates, MarkDubreuil, MaureenGore-Massy, MoniqueRomeo, NicolettaHaroon, NigilSufka, PaulGrainger, RebeccaHasseli, RebeccaLawson-Tovey, SaskiaBhana, SulemanPham, ThaoOlofsson, TorBautista-Molano, WilsonWallace, Zachary SYiu, Zenas Z NYazdany, JinoosRobinson, Philip CSmith, Catherine H2023-03-13T22:25:52Z2023-05-012023-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/150477eng0003-4967PURE: 54523109https://doi.org/10.1136/ard-2022-223499info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:26Zoai:run.unl.pt:10362/150477Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:08.157650Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries |
| title |
Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis |
| spellingShingle |
Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis Machado, Pedro M Arthritis Arthritis, Psoriatic Autoimmunity Covid-19 Spondylitis, Ankylosing SDG 3 - Good Health and Well-being |
| title_short |
Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis |
| title_full |
Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis |
| title_fullStr |
Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis |
| title_full_unstemmed |
Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis |
| title_sort |
Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis |
| author |
Machado, Pedro M |
| author_facet |
Machado, Pedro M Schäfer, Martin Mahil, Satveer K Liew, Jean Gossec, Laure Dand, Nick Pfeil, Alexander Strangfeld, Anja Regierer, Anne Constanze Fautrel, Bruno Alonso, Carla Gimena Saad, Carla G S Griffiths, Christopher E M Lomater, Claudia Miceli-Richard, Corinne Wendling, Daniel Alpizar Rodriguez, Deshire Wiek, Dieter Mateus, Elsa F Sirotich, Emily Soriano, Enrique R Ribeiro, Francinne Machado Omura, Felipe Rajão Martins, Frederico Santos, Helena Dau, Jonathan Barker, Jonathan N Hausmann, Jonathan Hyrich, Kimme L Gensler, Lianne Silva, Ligia Jacobsohn, Lindsay Carmona, Loreto Pinheiro, Marcelo M Zelaya, Marcos David Severina, María de Los Ángeles Yates, Mark Dubreuil, Maureen Gore-Massy, Monique Romeo, Nicoletta Haroon, Nigil Sufka, Paul Grainger, Rebecca Hasseli, Rebecca Lawson-Tovey, Saskia Bhana, Suleman Pham, Thao Olofsson, Tor Bautista-Molano, Wilson Wallace, Zachary S Yiu, Zenas Z N Yazdany, Jinoos Robinson, Philip C Smith, Catherine H |
| author_role |
author |
| author2 |
Schäfer, Martin Mahil, Satveer K Liew, Jean Gossec, Laure Dand, Nick Pfeil, Alexander Strangfeld, Anja Regierer, Anne Constanze Fautrel, Bruno Alonso, Carla Gimena Saad, Carla G S Griffiths, Christopher E M Lomater, Claudia Miceli-Richard, Corinne Wendling, Daniel Alpizar Rodriguez, Deshire Wiek, Dieter Mateus, Elsa F Sirotich, Emily Soriano, Enrique R Ribeiro, Francinne Machado Omura, Felipe Rajão Martins, Frederico Santos, Helena Dau, Jonathan Barker, Jonathan N Hausmann, Jonathan Hyrich, Kimme L Gensler, Lianne Silva, Ligia Jacobsohn, Lindsay Carmona, Loreto Pinheiro, Marcelo M Zelaya, Marcos David Severina, María de Los Ángeles Yates, Mark Dubreuil, Maureen Gore-Massy, Monique Romeo, Nicoletta Haroon, Nigil Sufka, Paul Grainger, Rebecca Hasseli, Rebecca Lawson-Tovey, Saskia Bhana, Suleman Pham, Thao Olofsson, Tor Bautista-Molano, Wilson Wallace, Zachary S Yiu, Zenas Z N Yazdany, Jinoos Robinson, Philip C Smith, Catherine H |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Machado, Pedro M Schäfer, Martin Mahil, Satveer K Liew, Jean Gossec, Laure Dand, Nick Pfeil, Alexander Strangfeld, Anja Regierer, Anne Constanze Fautrel, Bruno Alonso, Carla Gimena Saad, Carla G S Griffiths, Christopher E M Lomater, Claudia Miceli-Richard, Corinne Wendling, Daniel Alpizar Rodriguez, Deshire Wiek, Dieter Mateus, Elsa F Sirotich, Emily Soriano, Enrique R Ribeiro, Francinne Machado Omura, Felipe Rajão Martins, Frederico Santos, Helena Dau, Jonathan Barker, Jonathan N Hausmann, Jonathan Hyrich, Kimme L Gensler, Lianne Silva, Ligia Jacobsohn, Lindsay Carmona, Loreto Pinheiro, Marcelo M Zelaya, Marcos David Severina, María de Los Ángeles Yates, Mark Dubreuil, Maureen Gore-Massy, Monique Romeo, Nicoletta Haroon, Nigil Sufka, Paul Grainger, Rebecca Hasseli, Rebecca Lawson-Tovey, Saskia Bhana, Suleman Pham, Thao Olofsson, Tor Bautista-Molano, Wilson Wallace, Zachary S Yiu, Zenas Z N Yazdany, Jinoos Robinson, Philip C Smith, Catherine H |
| dc.subject.por.fl_str_mv |
Arthritis Arthritis, Psoriatic Autoimmunity Covid-19 Spondylitis, Ankylosing SDG 3 - Good Health and Well-being |
| topic |
Arthritis Arthritis, Psoriatic Autoimmunity Covid-19 Spondylitis, Ankylosing SDG 3 - Good Health and Well-being |
| description |
Funding The study received support from the American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-03-13T22:25:52Z 2023-05-01 2023-05-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/150477 |
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http://hdl.handle.net/10362/150477 |
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eng |
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eng |
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0003-4967 PURE: 54523109 https://doi.org/10.1136/ard-2022-223499 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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