Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis

Machado, Pedro M; Schäfer, Martin; Mahil, Satveer K; Liew, Jean; Gossec, Laure; Dand, Nick; Pfeil, Alexander; Strangfeld, Anja; Regierer, Anne Constanze; Fautrel, Bruno; Alonso, Carla Gimena; Saad, Carla G S; Griffiths, Christopher E M; Lomater, Claudia; Miceli-Richard, Corinne; Wendling, Daniel; Alpizar Rodriguez, Deshire; Wiek, Dieter; Mateus, Elsa F; Sirotich, Emily; Soriano, Enrique R; Ribeiro, Francinne Machado; Omura, Felipe; Rajão Martins, Frederico; Santos, Helena; Dau, Jonathan; Barker, Jonathan N; Hausmann, Jonathan; Hyrich, Kimme L; Gensler, Lianne; Silva, Ligia; Jacobsohn, Lindsay; Carmona, Loreto; Pinheiro, Marcelo M; Zelaya, Marcos David; Severina, María de Los Ángeles; Yates, Mark; Dubreuil, Maureen; Gore-Massy, Monique; Romeo, Nicoletta; Haroon, Nigil; Sufka, Paul; Grainger, Rebecca; Hasseli, Rebecca; Lawson-Tovey, Saskia; Bhana, Suleman; Pham, Thao; Olofsson, Tor; Bautista-Molano, Wilson; Wallace, Zachary S; Yiu, Zenas Z N; Yazdany, Jinoos; Robinson, Philip C; Smith, Catherine H

Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis

Bibliographic Details
Main Author:	Machado, Pedro M
Publication Date:	2023
Other Authors:	Schäfer, Martin, Mahil, Satveer K, Liew, Jean, Gossec, Laure, Dand, Nick, Pfeil, Alexander, Strangfeld, Anja, Regierer, Anne Constanze, Fautrel, Bruno, Alonso, Carla Gimena, Saad, Carla G S, Griffiths, Christopher E M, Lomater, Claudia, Miceli-Richard, Corinne, Wendling, Daniel, Alpizar Rodriguez, Deshire, Wiek, Dieter, Mateus, Elsa F, Sirotich, Emily, Soriano, Enrique R, Ribeiro, Francinne Machado, Omura, Felipe, Rajão Martins, Frederico, Santos, Helena, Dau, Jonathan, Barker, Jonathan N, Hausmann, Jonathan, Hyrich, Kimme L, Gensler, Lianne, Silva, Ligia, Jacobsohn, Lindsay, Carmona, Loreto, Pinheiro, Marcelo M, Zelaya, Marcos David, Severina, María de Los Ángeles, Yates, Mark, Dubreuil, Maureen, Gore-Massy, Monique, Romeo, Nicoletta, Haroon, Nigil, Sufka, Paul, Grainger, Rebecca, Hasseli, Rebecca, Lawson-Tovey, Saskia, Bhana, Suleman, Pham, Thao, Olofsson, Tor, Bautista-Molano, Wilson, Wallace, Zachary S, Yiu, Zenas Z N, Yazdany, Jinoos, Robinson, Philip C, Smith, Catherine H
Format:	Article
Language:	eng
Source:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full:	http://hdl.handle.net/10362/150477
Summary:	Funding The study received support from the American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR).

Item metadata

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oai_identifier_str	oai:run.unl.pt:10362/150477
network_acronym_str	RCAP
network_name_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str	7160
spelling	Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritisdata from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registriesArthritisArthritis, PsoriaticAutoimmunityCovid-19Spondylitis, AnkylosingSDG 3 - Good Health and Well-beingFunding The study received support from the American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR).OBJECTIVES: To investigate factors associated with severe COVID-19 in people with psoriasis (PsO), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). METHODS: Demographic data, clinical characteristics and COVID-19 outcome severity of adults with PsO, PsA and axSpA were obtained from two international physician-reported registries. A three-point ordinal COVID-19 severity scale was defined: no hospitalisation, hospitalisation (and no death) and death. ORs were estimated using multivariable ordinal logistic regression. RESULTS: Of 5045 cases, 18.3% had PsO, 45.5% PsA and 36.3% axSpA. Most (83.6%) were not hospitalised, 14.6% were hospitalised and 1.8% died. Older age was non-linearly associated with COVID-19 severity. Male sex (OR 1.54, 95% CI 1.30 to 1.83), cardiovascular, respiratory, renal, metabolic and cancer comorbidities (ORs 1.25-2.89), moderate/high disease activity and/or glucocorticoid use (ORs 1.39-2.23, vs remission/low disease activity and no glucocorticoids) were associated with increased odds of severe COVID-19. Later pandemic time periods (ORs 0.42-0.52, vs until 15 June 2020), PsO (OR 0.49, 95% CI 0.37 to 0.65, vs PsA) and baseline exposure to TNFi, IL17i and IL-23i/IL-12+23i (OR 0.57, 95% CI 0.44 to 0.73; OR 0.62, 95% CI 0.45 to 0.87; OR 0.67, 95% CI 0.45 to 0.98; respectively; vs no disease-modifying antirheumatic drug) were associated with reduced odds of severe COVID-19. CONCLUSION: Older age, male sex, comorbidity burden, higher disease activity and glucocorticoid intake were associated with more severe COVID-19. Later pandemic time periods, PsO and exposure to TNFi, IL17i and IL-23i/IL-12+23i were associated with less severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with PsO, PsA and axSpA during COVID-19 waves or similar future respiratory pandemics.NOVA Medical School\|Faculdade de Ciências Médicas (NMS\|FCM)RUNMachado, Pedro MSchäfer, MartinMahil, Satveer KLiew, JeanGossec, LaureDand, NickPfeil, AlexanderStrangfeld, AnjaRegierer, Anne ConstanzeFautrel, BrunoAlonso, Carla GimenaSaad, Carla G SGriffiths, Christopher E MLomater, ClaudiaMiceli-Richard, CorinneWendling, DanielAlpizar Rodriguez, DeshireWiek, DieterMateus, Elsa FSirotich, EmilySoriano, Enrique RRibeiro, Francinne MachadoOmura, FelipeRajão Martins, FredericoSantos, HelenaDau, JonathanBarker, Jonathan NHausmann, JonathanHyrich, Kimme LGensler, LianneSilva, LigiaJacobsohn, LindsayCarmona, LoretoPinheiro, Marcelo MZelaya, Marcos DavidSeverina, María de Los ÁngelesYates, MarkDubreuil, MaureenGore-Massy, MoniqueRomeo, NicolettaHaroon, NigilSufka, PaulGrainger, RebeccaHasseli, RebeccaLawson-Tovey, SaskiaBhana, SulemanPham, ThaoOlofsson, TorBautista-Molano, WilsonWallace, Zachary SYiu, Zenas Z NYazdany, JinoosRobinson, Philip CSmith, Catherine H2023-03-13T22:25:52Z2023-05-012023-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/150477eng0003-4967PURE: 54523109https://doi.org/10.1136/ard-2022-223499info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:26Zoai:run.unl.pt:10362/150477Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:08.157650Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv	Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries
title	Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis
spellingShingle	Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis Machado, Pedro M Arthritis Arthritis, Psoriatic Autoimmunity Covid-19 Spondylitis, Ankylosing SDG 3 - Good Health and Well-being
title_short	Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis
title_full	Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis
title_fullStr	Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis
title_full_unstemmed	Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis
title_sort	Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis
author	Machado, Pedro M
author_facet	Machado, Pedro M Schäfer, Martin Mahil, Satveer K Liew, Jean Gossec, Laure Dand, Nick Pfeil, Alexander Strangfeld, Anja Regierer, Anne Constanze Fautrel, Bruno Alonso, Carla Gimena Saad, Carla G S Griffiths, Christopher E M Lomater, Claudia Miceli-Richard, Corinne Wendling, Daniel Alpizar Rodriguez, Deshire Wiek, Dieter Mateus, Elsa F Sirotich, Emily Soriano, Enrique R Ribeiro, Francinne Machado Omura, Felipe Rajão Martins, Frederico Santos, Helena Dau, Jonathan Barker, Jonathan N Hausmann, Jonathan Hyrich, Kimme L Gensler, Lianne Silva, Ligia Jacobsohn, Lindsay Carmona, Loreto Pinheiro, Marcelo M Zelaya, Marcos David Severina, María de Los Ángeles Yates, Mark Dubreuil, Maureen Gore-Massy, Monique Romeo, Nicoletta Haroon, Nigil Sufka, Paul Grainger, Rebecca Hasseli, Rebecca Lawson-Tovey, Saskia Bhana, Suleman Pham, Thao Olofsson, Tor Bautista-Molano, Wilson Wallace, Zachary S Yiu, Zenas Z N Yazdany, Jinoos Robinson, Philip C Smith, Catherine H
author_role	author
author2	Schäfer, Martin Mahil, Satveer K Liew, Jean Gossec, Laure Dand, Nick Pfeil, Alexander Strangfeld, Anja Regierer, Anne Constanze Fautrel, Bruno Alonso, Carla Gimena Saad, Carla G S Griffiths, Christopher E M Lomater, Claudia Miceli-Richard, Corinne Wendling, Daniel Alpizar Rodriguez, Deshire Wiek, Dieter Mateus, Elsa F Sirotich, Emily Soriano, Enrique R Ribeiro, Francinne Machado Omura, Felipe Rajão Martins, Frederico Santos, Helena Dau, Jonathan Barker, Jonathan N Hausmann, Jonathan Hyrich, Kimme L Gensler, Lianne Silva, Ligia Jacobsohn, Lindsay Carmona, Loreto Pinheiro, Marcelo M Zelaya, Marcos David Severina, María de Los Ángeles Yates, Mark Dubreuil, Maureen Gore-Massy, Monique Romeo, Nicoletta Haroon, Nigil Sufka, Paul Grainger, Rebecca Hasseli, Rebecca Lawson-Tovey, Saskia Bhana, Suleman Pham, Thao Olofsson, Tor Bautista-Molano, Wilson Wallace, Zachary S Yiu, Zenas Z N Yazdany, Jinoos Robinson, Philip C Smith, Catherine H
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	NOVA Medical School\|Faculdade de Ciências Médicas (NMS\|FCM) RUN
dc.contributor.author.fl_str_mv	Machado, Pedro M Schäfer, Martin Mahil, Satveer K Liew, Jean Gossec, Laure Dand, Nick Pfeil, Alexander Strangfeld, Anja Regierer, Anne Constanze Fautrel, Bruno Alonso, Carla Gimena Saad, Carla G S Griffiths, Christopher E M Lomater, Claudia Miceli-Richard, Corinne Wendling, Daniel Alpizar Rodriguez, Deshire Wiek, Dieter Mateus, Elsa F Sirotich, Emily Soriano, Enrique R Ribeiro, Francinne Machado Omura, Felipe Rajão Martins, Frederico Santos, Helena Dau, Jonathan Barker, Jonathan N Hausmann, Jonathan Hyrich, Kimme L Gensler, Lianne Silva, Ligia Jacobsohn, Lindsay Carmona, Loreto Pinheiro, Marcelo M Zelaya, Marcos David Severina, María de Los Ángeles Yates, Mark Dubreuil, Maureen Gore-Massy, Monique Romeo, Nicoletta Haroon, Nigil Sufka, Paul Grainger, Rebecca Hasseli, Rebecca Lawson-Tovey, Saskia Bhana, Suleman Pham, Thao Olofsson, Tor Bautista-Molano, Wilson Wallace, Zachary S Yiu, Zenas Z N Yazdany, Jinoos Robinson, Philip C Smith, Catherine H
dc.subject.por.fl_str_mv	Arthritis Arthritis, Psoriatic Autoimmunity Covid-19 Spondylitis, Ankylosing SDG 3 - Good Health and Well-being
topic	Arthritis Arthritis, Psoriatic Autoimmunity Covid-19 Spondylitis, Ankylosing SDG 3 - Good Health and Well-being
description	Funding The study received support from the American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR).
publishDate	2023
dc.date.none.fl_str_mv	2023-03-13T22:25:52Z 2023-05-01 2023-05-01T00:00:00Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10362/150477
url	http://hdl.handle.net/10362/150477
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	0003-4967 PURE: 54523109 https://doi.org/10.1136/ard-2022-223499
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP
instname_str	Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str	RCAAP
institution	RCAAP
reponame_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis

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