The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes

Detalhes bibliográficos
Autor(a) principal: Bastos, HN
Data de Publicação: 2018
Outros Autores: Osório, N, Gagneux, S, Comas, I, Saraiva, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/126495
Resumo: The already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this troika for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB.
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spelling The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomesGenotypic diversityImmune phenotypesInflammationMicroenvironmentsSeverity of diseaseTuberculosisThe already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this troika for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB.Frontiers Media20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/126495eng1664-322410.3389/fimmu.2017.01948Bastos, HNOsório, NGagneux, SComas, ISaraiva, Minfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T07:31:17Zoai:repositorio-aberto.up.pt:10216/126495Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T07:31:17Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes
title The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes
spellingShingle The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes
Bastos, HN
Genotypic diversity
Immune phenotypes
Inflammation
Microenvironments
Severity of disease
Tuberculosis
title_short The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes
title_full The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes
title_fullStr The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes
title_full_unstemmed The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes
title_sort The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflammation and clinical outcomes
author Bastos, HN
author_facet Bastos, HN
Osório, N
Gagneux, S
Comas, I
Saraiva, M
author_role author
author2 Osório, N
Gagneux, S
Comas, I
Saraiva, M
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bastos, HN
Osório, N
Gagneux, S
Comas, I
Saraiva, M
dc.subject.por.fl_str_mv Genotypic diversity
Immune phenotypes
Inflammation
Microenvironments
Severity of disease
Tuberculosis
topic Genotypic diversity
Immune phenotypes
Inflammation
Microenvironments
Severity of disease
Tuberculosis
description The already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this troika for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/126495
url https://hdl.handle.net/10216/126495
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-3224
10.3389/fimmu.2017.01948
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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