The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes

Detalhes bibliográficos
Autor(a) principal: Bastos, Hélder Novais
Data de Publicação: 2018
Outros Autores: Osório, Nuno S., Gagneux, Sebastien, Comas, Iñaki, Saraiva, Margarida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/50254
Resumo: The Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes
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spelling The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomestuberculosisgenotypic diversityimmune phenotypesseverity of diseaseinflammationmicroenvironmentsScience & TechnologyThe Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical OutcomesThe already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this troika for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB.HN-B acknowledges the receipt of research scholarships from Bolsa D. Manuel de Mello and the Portuguese Society for Pneumology. NO acknowledges FCT IF/00474/2014. SG is funded by the European Research Council (grant number 309540-EVODRTB); the Swiss National Science Foundation (grant number 310030_166687) SystemsX.ch. IC lab is financed by Ministerio de Economía y Competitividad (Spanish Government) research grant SAF2013-43521-R, SAF2016- 77346-R, and PROMETEO/2016/122 from Generalitat Valenciana and the European Research Council (ERC) (638553-TB-ACCELERATE). The MS lab is financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). MS is an FCT Principal Investigator. Some graphical elements in the figures were designed by kjpargeter/Freepik. The funding agencies had no role in the design of the manuscriptinfo:eu-repo/semantics/publishedVersionFrontiers MediaUniversidade do MinhoBastos, Hélder NovaisOsório, Nuno S.Gagneux, SebastienComas, IñakiSaraiva, Margarida2018-01-092018-01-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/50254eng1664-32241664-322410.3389/fimmu.2017.01948https://www.frontiersin.org/journals/immunology#info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:09:33Zoai:repositorium.sdum.uminho.pt:1822/50254Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:00:58.407755Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes
title The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes
spellingShingle The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes
Bastos, Hélder Novais
tuberculosis
genotypic diversity
immune phenotypes
severity of disease
inflammation
microenvironments
Science & Technology
title_short The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes
title_full The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes
title_fullStr The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes
title_full_unstemmed The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes
title_sort The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes
author Bastos, Hélder Novais
author_facet Bastos, Hélder Novais
Osório, Nuno S.
Gagneux, Sebastien
Comas, Iñaki
Saraiva, Margarida
author_role author
author2 Osório, Nuno S.
Gagneux, Sebastien
Comas, Iñaki
Saraiva, Margarida
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Bastos, Hélder Novais
Osório, Nuno S.
Gagneux, Sebastien
Comas, Iñaki
Saraiva, Margarida
dc.subject.por.fl_str_mv tuberculosis
genotypic diversity
immune phenotypes
severity of disease
inflammation
microenvironments
Science & Technology
topic tuberculosis
genotypic diversity
immune phenotypes
severity of disease
inflammation
microenvironments
Science & Technology
description The Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes
publishDate 2018
dc.date.none.fl_str_mv 2018-01-09
2018-01-09T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/50254
url http://hdl.handle.net/1822/50254
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-3224
1664-3224
10.3389/fimmu.2017.01948
https://www.frontiersin.org/journals/immunology#
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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