The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization

Detalhes bibliográficos
Autor(a) principal: Barrière, D. A.
Data de Publicação: 2019
Outros Autores: Magalhães, R., Novais, A., Marques, P., Selingue, E., Geffroy, F., Marques, F., Cerqueira, J., Sousa, J. C., Boumezbeur, F., Bottlaender, M., Jay, T. M., Cachia, A., Sousa, Nuno, Mériaux, S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/67212
Resumo: Preclinical imaging studies offer a unique access to the rat brain, allowing investigations that go beyond what is possible in human studies. Unfortunately, these techniques still suffer from a lack of dedicated and standardized neuroimaging tools, namely brain templates and descriptive atlases. Here, we present two rat brain MRI templates and their associated gray matter, white matter and cerebrospinal fluid probability maps, generated from ex vivo [Formula: see text]-weighted images (90 µm isotropic resolution) and in vivo T2-weighted images (150 µm isotropic resolution). In association with these templates, we also provide both anatomical and functional 3D brain atlases, respectively derived from the merging of the Waxholm and Tohoku atlases, and analysis of resting-state functional MRI data. Finally, we propose a complete set of preclinical MRI reference resources, compatible with common neuroimaging software, for the investigation of rat brain structures and functions.
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spelling The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualizationAnimalsBrain MappingCerebrospinal FluidGray MatterImaging, Three-DimensionalMaleModels, AnimalRatsRats, WistarSoftwareWhite MatterAtlases as TopicMagnetic Resonance ImagingCiências Médicas::Ciências da SaúdeScience & TechnologyPreclinical imaging studies offer a unique access to the rat brain, allowing investigations that go beyond what is possible in human studies. Unfortunately, these techniques still suffer from a lack of dedicated and standardized neuroimaging tools, namely brain templates and descriptive atlases. Here, we present two rat brain MRI templates and their associated gray matter, white matter and cerebrospinal fluid probability maps, generated from ex vivo [Formula: see text]-weighted images (90 µm isotropic resolution) and in vivo T2-weighted images (150 µm isotropic resolution). In association with these templates, we also provide both anatomical and functional 3D brain atlases, respectively derived from the merging of the Waxholm and Tohoku atlases, and analysis of resting-state functional MRI data. Finally, we propose a complete set of preclinical MRI reference resources, compatible with common neuroimaging software, for the investigation of rat brain structures and functions.This work is part of the SIGMA project with the reference FCT-ANR/NEU-OSD/0258/2012, co-financed by the French public funding agency ANR (Agence Nationale pour laRecherche, APP Blanc International II 2012), the Portuguese FCT (Fundação para aCiência e Tecnologia) and the Portuguese North Regional Operational Program (ON.2—O Novo Norte) under the National Strategic Reference Framework (QREN), through theEuropean Regional Development Fund (FEDER) as well as the Projecto Estratégico co-funded by FCT (PEst-C/SAU/LA0026-/2013) and the European Regional DevelopmentFund COMPETE (FCOMP-01-0124-FEDER-037298). D.A.B. and A.N. were funded bygrants from FCT-ANR/NEU-OSD/0258/2012. R.M. was supported by the FCT fellow-ship grant with the reference PDE/BDE/113604/2015 from the PhDiHES program. A.C.was supported by a grant from the foundation NRJ. P.M. was funded by FundaçãoCalouste Gulbenkian (Portugal;‘Better mental health during ageing based on temporalprediction of individual brain ageing trajectories TEMPO’) with Grant Number P-139977. France Life Imaging is acknowledged for its support in funding the NeuroSpinplatform of preclinical MRI scanners. The authors also acknowledge and thank EdwardGanz, MD, for proof reading our work.Nature ResearchUniversidade do MinhoBarrière, D. A.Magalhães, R.Novais, A.Marques, P.Selingue, E.Geffroy, F.Marques, F.Cerqueira, J.Sousa, J. C.Boumezbeur, F.Bottlaender, M.Jay, T. M.Cachia, A.Sousa, NunoMériaux, S.20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/67212eng2041-17232041-172310.1038/s41467-019-13575-731836716https://www.nature.com/articles/s41467-019-13575-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:55:20Zoai:repositorium.sdum.uminho.pt:1822/67212Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:44:52.903343Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
title The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
spellingShingle The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
Barrière, D. A.
Animals
Brain Mapping
Cerebrospinal Fluid
Gray Matter
Imaging, Three-Dimensional
Male
Models, Animal
Rats
Rats, Wistar
Software
White Matter
Atlases as Topic
Magnetic Resonance Imaging
Ciências Médicas::Ciências da Saúde
Science & Technology
title_short The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
title_full The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
title_fullStr The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
title_full_unstemmed The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
title_sort The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
author Barrière, D. A.
author_facet Barrière, D. A.
Magalhães, R.
Novais, A.
Marques, P.
Selingue, E.
Geffroy, F.
Marques, F.
Cerqueira, J.
Sousa, J. C.
Boumezbeur, F.
Bottlaender, M.
Jay, T. M.
Cachia, A.
Sousa, Nuno
Mériaux, S.
author_role author
author2 Magalhães, R.
Novais, A.
Marques, P.
Selingue, E.
Geffroy, F.
Marques, F.
Cerqueira, J.
Sousa, J. C.
Boumezbeur, F.
Bottlaender, M.
Jay, T. M.
Cachia, A.
Sousa, Nuno
Mériaux, S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Barrière, D. A.
Magalhães, R.
Novais, A.
Marques, P.
Selingue, E.
Geffroy, F.
Marques, F.
Cerqueira, J.
Sousa, J. C.
Boumezbeur, F.
Bottlaender, M.
Jay, T. M.
Cachia, A.
Sousa, Nuno
Mériaux, S.
dc.subject.por.fl_str_mv Animals
Brain Mapping
Cerebrospinal Fluid
Gray Matter
Imaging, Three-Dimensional
Male
Models, Animal
Rats
Rats, Wistar
Software
White Matter
Atlases as Topic
Magnetic Resonance Imaging
Ciências Médicas::Ciências da Saúde
Science & Technology
topic Animals
Brain Mapping
Cerebrospinal Fluid
Gray Matter
Imaging, Three-Dimensional
Male
Models, Animal
Rats
Rats, Wistar
Software
White Matter
Atlases as Topic
Magnetic Resonance Imaging
Ciências Médicas::Ciências da Saúde
Science & Technology
description Preclinical imaging studies offer a unique access to the rat brain, allowing investigations that go beyond what is possible in human studies. Unfortunately, these techniques still suffer from a lack of dedicated and standardized neuroimaging tools, namely brain templates and descriptive atlases. Here, we present two rat brain MRI templates and their associated gray matter, white matter and cerebrospinal fluid probability maps, generated from ex vivo [Formula: see text]-weighted images (90 µm isotropic resolution) and in vivo T2-weighted images (150 µm isotropic resolution). In association with these templates, we also provide both anatomical and functional 3D brain atlases, respectively derived from the merging of the Waxholm and Tohoku atlases, and analysis of resting-state functional MRI data. Finally, we propose a complete set of preclinical MRI reference resources, compatible with common neuroimaging software, for the investigation of rat brain structures and functions.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/67212
url http://hdl.handle.net/1822/67212
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2041-1723
2041-1723
10.1038/s41467-019-13575-7
31836716
https://www.nature.com/articles/s41467-019-13575-7
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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