The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/67212 |
Resumo: | Preclinical imaging studies offer a unique access to the rat brain, allowing investigations that go beyond what is possible in human studies. Unfortunately, these techniques still suffer from a lack of dedicated and standardized neuroimaging tools, namely brain templates and descriptive atlases. Here, we present two rat brain MRI templates and their associated gray matter, white matter and cerebrospinal fluid probability maps, generated from ex vivo [Formula: see text]-weighted images (90 µm isotropic resolution) and in vivo T2-weighted images (150 µm isotropic resolution). In association with these templates, we also provide both anatomical and functional 3D brain atlases, respectively derived from the merging of the Waxholm and Tohoku atlases, and analysis of resting-state functional MRI data. Finally, we propose a complete set of preclinical MRI reference resources, compatible with common neuroimaging software, for the investigation of rat brain structures and functions. |
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The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualizationAnimalsBrain MappingCerebrospinal FluidGray MatterImaging, Three-DimensionalMaleModels, AnimalRatsRats, WistarSoftwareWhite MatterAtlases as TopicMagnetic Resonance ImagingCiências Médicas::Ciências da SaúdeScience & TechnologyPreclinical imaging studies offer a unique access to the rat brain, allowing investigations that go beyond what is possible in human studies. Unfortunately, these techniques still suffer from a lack of dedicated and standardized neuroimaging tools, namely brain templates and descriptive atlases. Here, we present two rat brain MRI templates and their associated gray matter, white matter and cerebrospinal fluid probability maps, generated from ex vivo [Formula: see text]-weighted images (90 µm isotropic resolution) and in vivo T2-weighted images (150 µm isotropic resolution). In association with these templates, we also provide both anatomical and functional 3D brain atlases, respectively derived from the merging of the Waxholm and Tohoku atlases, and analysis of resting-state functional MRI data. Finally, we propose a complete set of preclinical MRI reference resources, compatible with common neuroimaging software, for the investigation of rat brain structures and functions.This work is part of the SIGMA project with the reference FCT-ANR/NEU-OSD/0258/2012, co-financed by the French public funding agency ANR (Agence Nationale pour laRecherche, APP Blanc International II 2012), the Portuguese FCT (Fundação para aCiência e Tecnologia) and the Portuguese North Regional Operational Program (ON.2—O Novo Norte) under the National Strategic Reference Framework (QREN), through theEuropean Regional Development Fund (FEDER) as well as the Projecto Estratégico co-funded by FCT (PEst-C/SAU/LA0026-/2013) and the European Regional DevelopmentFund COMPETE (FCOMP-01-0124-FEDER-037298). D.A.B. and A.N. were funded bygrants from FCT-ANR/NEU-OSD/0258/2012. R.M. was supported by the FCT fellow-ship grant with the reference PDE/BDE/113604/2015 from the PhDiHES program. A.C.was supported by a grant from the foundation NRJ. P.M. was funded by FundaçãoCalouste Gulbenkian (Portugal;‘Better mental health during ageing based on temporalprediction of individual brain ageing trajectories TEMPO’) with Grant Number P-139977. France Life Imaging is acknowledged for its support in funding the NeuroSpinplatform of preclinical MRI scanners. The authors also acknowledge and thank EdwardGanz, MD, for proof reading our work.Nature ResearchUniversidade do MinhoBarrière, D. A.Magalhães, R.Novais, A.Marques, P.Selingue, E.Geffroy, F.Marques, F.Cerqueira, J.Sousa, J. C.Boumezbeur, F.Bottlaender, M.Jay, T. M.Cachia, A.Sousa, NunoMériaux, S.20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/67212eng2041-17232041-172310.1038/s41467-019-13575-731836716https://www.nature.com/articles/s41467-019-13575-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:55:20Zoai:repositorium.sdum.uminho.pt:1822/67212Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:44:52.903343Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization |
title |
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization |
spellingShingle |
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization Barrière, D. A. Animals Brain Mapping Cerebrospinal Fluid Gray Matter Imaging, Three-Dimensional Male Models, Animal Rats Rats, Wistar Software White Matter Atlases as Topic Magnetic Resonance Imaging Ciências Médicas::Ciências da Saúde Science & Technology |
title_short |
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization |
title_full |
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization |
title_fullStr |
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization |
title_full_unstemmed |
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization |
title_sort |
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization |
author |
Barrière, D. A. |
author_facet |
Barrière, D. A. Magalhães, R. Novais, A. Marques, P. Selingue, E. Geffroy, F. Marques, F. Cerqueira, J. Sousa, J. C. Boumezbeur, F. Bottlaender, M. Jay, T. M. Cachia, A. Sousa, Nuno Mériaux, S. |
author_role |
author |
author2 |
Magalhães, R. Novais, A. Marques, P. Selingue, E. Geffroy, F. Marques, F. Cerqueira, J. Sousa, J. C. Boumezbeur, F. Bottlaender, M. Jay, T. M. Cachia, A. Sousa, Nuno Mériaux, S. |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Barrière, D. A. Magalhães, R. Novais, A. Marques, P. Selingue, E. Geffroy, F. Marques, F. Cerqueira, J. Sousa, J. C. Boumezbeur, F. Bottlaender, M. Jay, T. M. Cachia, A. Sousa, Nuno Mériaux, S. |
dc.subject.por.fl_str_mv |
Animals Brain Mapping Cerebrospinal Fluid Gray Matter Imaging, Three-Dimensional Male Models, Animal Rats Rats, Wistar Software White Matter Atlases as Topic Magnetic Resonance Imaging Ciências Médicas::Ciências da Saúde Science & Technology |
topic |
Animals Brain Mapping Cerebrospinal Fluid Gray Matter Imaging, Three-Dimensional Male Models, Animal Rats Rats, Wistar Software White Matter Atlases as Topic Magnetic Resonance Imaging Ciências Médicas::Ciências da Saúde Science & Technology |
description |
Preclinical imaging studies offer a unique access to the rat brain, allowing investigations that go beyond what is possible in human studies. Unfortunately, these techniques still suffer from a lack of dedicated and standardized neuroimaging tools, namely brain templates and descriptive atlases. Here, we present two rat brain MRI templates and their associated gray matter, white matter and cerebrospinal fluid probability maps, generated from ex vivo [Formula: see text]-weighted images (90 µm isotropic resolution) and in vivo T2-weighted images (150 µm isotropic resolution). In association with these templates, we also provide both anatomical and functional 3D brain atlases, respectively derived from the merging of the Waxholm and Tohoku atlases, and analysis of resting-state functional MRI data. Finally, we propose a complete set of preclinical MRI reference resources, compatible with common neuroimaging software, for the investigation of rat brain structures and functions. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/67212 |
url |
http://hdl.handle.net/1822/67212 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2041-1723 2041-1723 10.1038/s41467-019-13575-7 31836716 https://www.nature.com/articles/s41467-019-13575-7 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Research |
publisher.none.fl_str_mv |
Nature Research |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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