Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster

Detalhes bibliográficos
Autor(a) principal: Andrade, Vasco Maria Horta e Costa Freire de
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/62219
Resumo: Tese de mestrado, Biologia Molecular e Genética, 2023, Universidade de Lisboa, Faculdade de Ciências
id RCAP_6a6d0aca2ebc9e90bb3843fdbb4147c3
oai_identifier_str oai:repositorio.ul.pt:10451/62219
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Understanding the influence of the central brain on coordinated walking using Drosophila melanogastercomportamentolocomoçãocentral complexTeses de mestrado - 2023Departamento de Biologia VegetalTese de mestrado, Biologia Molecular e Genética, 2023, Universidade de Lisboa, Faculdade de CiênciasCoordinated walking is a fundamental biological activity across the animal kingdom. When functioning correctly, it enables animals to forage for food, evade threats, and seek potential mates for reproduction. In the case of humans, our ability to walk in a coordinated manner significantly contributes to our overall quality of life. Therefore, gaining insights into the mechanisms underlying this activity and maintaining its health are of paramount importance. The fruit fly, Drosophila melanogaster, stands out as an excellent model for exploring this topic, thanks to its robust genetic tools and comprehensive kinematic measurement methods. Locomotion in fruit flies is regulated by basic circuits located in the ventral nerve cord, which are modulated by input from higher-level control centers in the central brain. These control centers process sensory information and adjust the walking patterns accordingly. One specific brain region, known as the central complex, serves as a higher-order motor control center. Comparable to the basal ganglia or cerebellum in vertebrates, the central complex comprises four subunits: ellipsoid body, fan-shaped body, noduli, and protocerebral bridge. Research has shown that these neural structures play a role in controlling various aspects of walking and goal-directed locomotion, among other functions. However, our understanding of the cellular and circuit-level mechanisms, as well as the detailed functions of these components, remains incomplete. This study has two main objectives: (1) to comprehend how central complex substructures impact diverse locomotion parameters and (2) to introduce an innovative approach for investigating the first objective further. The findings reveal the ability to link distinct central complex regions with various locomotion parameters, each showing varying degrees of influence. While the implemented approach is not yet fully developed, it shows potential for future research into the influence of central complex substructures on locomotion.Mendes, César S.Carvalho, Margarida Henriques da Gama, 1972-Repositório da Universidade de LisboaAndrade, Vasco Maria Horta e Costa Freire de2024-01-25T09:55:44Z202320232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/62219engmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-29T01:21:13Zoai:repositorio.ul.pt:10451/62219Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:58:39.282187Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster
title Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster
spellingShingle Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster
Andrade, Vasco Maria Horta e Costa Freire de
comportamento
locomoção
central complex
Teses de mestrado - 2023
Departamento de Biologia Vegetal
title_short Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster
title_full Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster
title_fullStr Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster
title_full_unstemmed Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster
title_sort Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster
author Andrade, Vasco Maria Horta e Costa Freire de
author_facet Andrade, Vasco Maria Horta e Costa Freire de
author_role author
dc.contributor.none.fl_str_mv Mendes, César S.
Carvalho, Margarida Henriques da Gama, 1972-
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Andrade, Vasco Maria Horta e Costa Freire de
dc.subject.por.fl_str_mv comportamento
locomoção
central complex
Teses de mestrado - 2023
Departamento de Biologia Vegetal
topic comportamento
locomoção
central complex
Teses de mestrado - 2023
Departamento de Biologia Vegetal
description Tese de mestrado, Biologia Molecular e Genética, 2023, Universidade de Lisboa, Faculdade de Ciências
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023-01-01T00:00:00Z
2024-01-25T09:55:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/62219
url http://hdl.handle.net/10451/62219
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137071216984064

Registros relacionados