Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure

Detalhes bibliográficos
Autor(a) principal: Araújo, Ana Rita Rodrigues
Data de Publicação: 2020
Outros Autores: Camero, Sérgio, Taboada, Pablo, Reis, R. L., Pires, R. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/63909
Resumo: Accepted Manuscript ; "First published on 10 Feb 2020"
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spelling Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structureAlzheimer's diseaseAmyloid-betaNatural polyphenolsScience & TechnologyAccepted Manuscript ; "First published on 10 Feb 2020"The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.We acknowledge the financial support from the EC (FORECAST - 668983 and THE DISCOVERIES CTR – 739572), “Programa Operacional Regional do Norte”, “Fundo Social Europeu”, Norte2020 TERM&SC, for the PhD grant NORTE-08-5369-FSE-000044; PT acknowledges Agencia Estatal de Investigación (AEI) for Project MAT2016-80266-R, and “Xunta de Galicia” for grants “Grupo de Referencia Competitiva” ED431C 2018/26 and “Agrupación Estratégica en Materiales-AEMAT” ED431E 2018/08, respectively. ERDF funds are also acknowledged.Royal Society of ChemistryUniversidade do MinhoAraújo, Ana Rita RodriguesCamero, SérgioTaboada, PabloReis, R. L.Pires, R. A.2020-022020-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/63909engAraújo A. R., Gigante S. C., Taboada P., Reis R. L., Pires R. A. Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure, Chemical Communications (RSC), doi:10.1039/D0CC00192A, 20201359-73451364-548X10.1039/D0CC00192A32068230https://pubs.rsc.org/en/content/articlelanding/2020/cc/d0cc00192a/unauth#!divAbstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:59:33Zoai:repositorium.sdum.uminho.pt:1822/63909Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:49:20.451173Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
title Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
spellingShingle Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
Araújo, Ana Rita Rodrigues
Alzheimer's disease
Amyloid-beta
Natural polyphenols
Science & Technology
title_short Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
title_full Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
title_fullStr Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
title_full_unstemmed Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
title_sort Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure
author Araújo, Ana Rita Rodrigues
author_facet Araújo, Ana Rita Rodrigues
Camero, Sérgio
Taboada, Pablo
Reis, R. L.
Pires, R. A.
author_role author
author2 Camero, Sérgio
Taboada, Pablo
Reis, R. L.
Pires, R. A.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Araújo, Ana Rita Rodrigues
Camero, Sérgio
Taboada, Pablo
Reis, R. L.
Pires, R. A.
dc.subject.por.fl_str_mv Alzheimer's disease
Amyloid-beta
Natural polyphenols
Science & Technology
topic Alzheimer's disease
Amyloid-beta
Natural polyphenols
Science & Technology
description Accepted Manuscript ; "First published on 10 Feb 2020"
publishDate 2020
dc.date.none.fl_str_mv 2020-02
2020-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/63909
url http://hdl.handle.net/1822/63909
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Araújo A. R., Gigante S. C., Taboada P., Reis R. L., Pires R. A. Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure, Chemical Communications (RSC), doi:10.1039/D0CC00192A, 2020
1359-7345
1364-548X
10.1039/D0CC00192A
32068230
https://pubs.rsc.org/en/content/articlelanding/2020/cc/d0cc00192a/unauth#!divAbstract
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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