Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease

Detalhes bibliográficos
Autor(a) principal: Mateus, Vanessa
Data de Publicação: 2021
Outros Autores: Estarreja, João, Silva, Inês, Barracosa, Paulo, Teixeira-Lemos, Edite, Pinto, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/12842
Resumo: UIDB/05608/2020 and UIDP/05608/2020
id RCAP_6b1bae3cb584417ee4691085c139b8b7
oai_identifier_str oai:repositorio.ipl.pt:10400.21/12842
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel diseaseCardoonCynara cardunculus L.PolyphenolsColitisInflammationInflammatory bowel diseaseTNBS-induced colitisHerbal medicinesUIDB/05608/2020UIDP/05608/2020UIDB/05608/2020 and UIDP/05608/2020Background: Cynara cardunculus L. var. altilis (DC) is a plant generally associated as an ingredient in the Mediterranean diet. The polyphenols present in this plant provide pharmacological and nutritional properties. C. cardunculus L. has been used throughout animal studies, which demonstrated an anti-inflammatory effect. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Since there is not a known cure, the research of new possible pharmacological approaches is essential. This study aims to evaluate the effect of an aqueous extract of C. cardunculus L. dry leaves in a 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis model. Methods: CD-1 mice with TNBS-induced colitis received an intraperitoneal (IP) administration of C. cardunculus L. once per day for 4 days. Results: The C. cardunculus L. demonstrated a beneficial effect in this experimental model of IBD with anti-inflammatory action through the reduction of tumor necrosis factor (TNF)-α levels. It also demonstrated a beneficial influence on the extra-intestinal manifestations related to IBD, with the absence of significant side effects of its use. Conclusions: The extract of C. cardunculus L. dry leaves can become an interesting tool for new possible pharmacological approaches in the management of IBD.MDPIRCIPLMateus, VanessaEstarreja, JoãoSilva, InêsBarracosa, PauloTeixeira-Lemos, EditePinto, Rui2021-02-12T20:24:19Z2021-022021-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/12842engMateus V, Estarreja J, Silva I, Barracosa P, Teixeira-Lemos E, Pinto R. Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease. Appl Sci. 2021;11(4):1629.10.3390/app11041629info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:06:33Zoai:repositorio.ipl.pt:10400.21/12842Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:20:51.601223Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease
title Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease
spellingShingle Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease
Mateus, Vanessa
Cardoon
Cynara cardunculus L.
Polyphenols
Colitis
Inflammation
Inflammatory bowel disease
TNBS-induced colitis
Herbal medicines
UIDB/05608/2020
UIDP/05608/2020
title_short Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease
title_full Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease
title_fullStr Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease
title_full_unstemmed Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease
title_sort Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease
author Mateus, Vanessa
author_facet Mateus, Vanessa
Estarreja, João
Silva, Inês
Barracosa, Paulo
Teixeira-Lemos, Edite
Pinto, Rui
author_role author
author2 Estarreja, João
Silva, Inês
Barracosa, Paulo
Teixeira-Lemos, Edite
Pinto, Rui
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Mateus, Vanessa
Estarreja, João
Silva, Inês
Barracosa, Paulo
Teixeira-Lemos, Edite
Pinto, Rui
dc.subject.por.fl_str_mv Cardoon
Cynara cardunculus L.
Polyphenols
Colitis
Inflammation
Inflammatory bowel disease
TNBS-induced colitis
Herbal medicines
UIDB/05608/2020
UIDP/05608/2020
topic Cardoon
Cynara cardunculus L.
Polyphenols
Colitis
Inflammation
Inflammatory bowel disease
TNBS-induced colitis
Herbal medicines
UIDB/05608/2020
UIDP/05608/2020
description UIDB/05608/2020 and UIDP/05608/2020
publishDate 2021
dc.date.none.fl_str_mv 2021-02-12T20:24:19Z
2021-02
2021-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/12842
url http://hdl.handle.net/10400.21/12842
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mateus V, Estarreja J, Silva I, Barracosa P, Teixeira-Lemos E, Pinto R. Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease. Appl Sci. 2021;11(4):1629.
10.3390/app11041629
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133478373031936

Registros relacionados