Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studies

Detalhes bibliográficos
Autor(a) principal: Fernandes, Maria J. G.
Data de Publicação: 2008
Outros Autores: Gonçalves, M. Sameiro T., Costa, Susana P. G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/86474
Resumo: A series of fluorescent conjugates of neurotransmitter amino acids, such as P-alanine, tyrosine, 3,4-dihydroxyplienylalanine (DOPA) and glutamic acid, were prepared by reaction with a suitable fluorophore, namely 1-chloromethyl-9-methoxy-3-oxo-3H-benzo[f]benzopyran. The photophysical properties of the resulting ester bioconjugates were evaluated as well as the stability to photolysis at different wavelengths of irradiation (250, 300, 350 and 419 nm).
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spelling Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studiesOxobenzobenzopyranBenzocoumarinNeurotransmittersAmino acidsPhotolysisBenzocoumarin NeurotransmittersCiências Naturais::Ciências QuímicasScience & TechnologyA series of fluorescent conjugates of neurotransmitter amino acids, such as P-alanine, tyrosine, 3,4-dihydroxyplienylalanine (DOPA) and glutamic acid, were prepared by reaction with a suitable fluorophore, namely 1-chloromethyl-9-methoxy-3-oxo-3H-benzo[f]benzopyran. The photophysical properties of the resulting ester bioconjugates were evaluated as well as the stability to photolysis at different wavelengths of irradiation (250, 300, 350 and 419 nm).Thanks are due to the Foundation for Science and Technology (Portugal) for financial support through project PTDC/QUI/69607/2006 and a Ph.D. grant to M.J.G.F. (SFRH/BD/36695/2007).Pergamon-Elsevier Science LtdUniversidade do MinhoFernandes, Maria J. G.Gonçalves, M. Sameiro T.Costa, Susana P. G.20082008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/86474engFernandes, M. J. G., Gonçalves, M. S. T., & Costa, S. P. G. (2008, December). Neurotransmitter amino acid—oxobenzo[f]benzopyran conjugates: synthesis and photorelease studies. Tetrahedron. Elsevier BV. http://doi.org/10.1016/j.tet.2008.09.0500040-402010.1016/j.tet.2008.09.050https://www.sciencedirect.com/science/article/pii/S0040402008016918info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-23T01:18:26Zoai:repositorium.sdum.uminho.pt:1822/86474Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:30:39.599568Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studies
title Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studies
spellingShingle Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studies
Fernandes, Maria J. G.
Oxobenzobenzopyran
Benzocoumarin
Neurotransmitters
Amino acids
Photolysis
Benzocoumarin Neurotransmitters
Ciências Naturais::Ciências Químicas
Science & Technology
title_short Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studies
title_full Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studies
title_fullStr Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studies
title_full_unstemmed Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studies
title_sort Neurotransmitter amino acid-oxobenzo [f]benzopyran conjugates: synthesis and photorelease studies
author Fernandes, Maria J. G.
author_facet Fernandes, Maria J. G.
Gonçalves, M. Sameiro T.
Costa, Susana P. G.
author_role author
author2 Gonçalves, M. Sameiro T.
Costa, Susana P. G.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Fernandes, Maria J. G.
Gonçalves, M. Sameiro T.
Costa, Susana P. G.
dc.subject.por.fl_str_mv Oxobenzobenzopyran
Benzocoumarin
Neurotransmitters
Amino acids
Photolysis
Benzocoumarin Neurotransmitters
Ciências Naturais::Ciências Químicas
Science & Technology
topic Oxobenzobenzopyran
Benzocoumarin
Neurotransmitters
Amino acids
Photolysis
Benzocoumarin Neurotransmitters
Ciências Naturais::Ciências Químicas
Science & Technology
description A series of fluorescent conjugates of neurotransmitter amino acids, such as P-alanine, tyrosine, 3,4-dihydroxyplienylalanine (DOPA) and glutamic acid, were prepared by reaction with a suitable fluorophore, namely 1-chloromethyl-9-methoxy-3-oxo-3H-benzo[f]benzopyran. The photophysical properties of the resulting ester bioconjugates were evaluated as well as the stability to photolysis at different wavelengths of irradiation (250, 300, 350 and 419 nm).
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/86474
url https://hdl.handle.net/1822/86474
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes, M. J. G., Gonçalves, M. S. T., & Costa, S. P. G. (2008, December). Neurotransmitter amino acid—oxobenzo[f]benzopyran conjugates: synthesis and photorelease studies. Tetrahedron. Elsevier BV. http://doi.org/10.1016/j.tet.2008.09.050
0040-4020
10.1016/j.tet.2008.09.050
https://www.sciencedirect.com/science/article/pii/S0040402008016918
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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