Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/67673 |
Resumo: | As an immune-privileged target organ, the eyes have important superficial and internal barriers, protecting them from physical and chemical damage from exogenous and/or endogenous origins that would cause injury to visual acuity or even vision loss. These anatomic, physiological and histologic barriers are thus a challenge for drug access and entry into the eye. Novel therapeutic concepts are highly desirable for eye treatment. The design of an efficient ocular drug delivery system still remains a challenge. Although nanotechnology may offer the ability to detect and treat eye diseases, successful treatment approaches are still in demand. The growing interest in nanopharmaceuticals offers the opportunity to improve ophthalmic treatments. Besides their size, which needs to be critically monitored, nanopharmaceuticals for ophthalmic applications have to be produced under sterilized conditions. In this work, we have revised the different sterilization and depyrogenation methods for ophthalmic nanopharmaceuticals with their merits and drawbacks. The paper also describes clinical sterilization of drugs and the outcomes of inappropriate practices, while recent applications of nanopharmaceuticals for ocular drug delivery are also addressed. |
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Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applicationseye administrationocular drug deliverynanopharmaceuticalsophthalmic treatmentssterilizationdepyrogenationScience & TechnologyAs an immune-privileged target organ, the eyes have important superficial and internal barriers, protecting them from physical and chemical damage from exogenous and/or endogenous origins that would cause injury to visual acuity or even vision loss. These anatomic, physiological and histologic barriers are thus a challenge for drug access and entry into the eye. Novel therapeutic concepts are highly desirable for eye treatment. The design of an efficient ocular drug delivery system still remains a challenge. Although nanotechnology may offer the ability to detect and treat eye diseases, successful treatment approaches are still in demand. The growing interest in nanopharmaceuticals offers the opportunity to improve ophthalmic treatments. Besides their size, which needs to be critically monitored, nanopharmaceuticals for ophthalmic applications have to be produced under sterilized conditions. In this work, we have revised the different sterilization and depyrogenation methods for ophthalmic nanopharmaceuticals with their merits and drawbacks. The paper also describes clinical sterilization of drugs and the outcomes of inappropriate practices, while recent applications of nanopharmaceuticals for ocular drug delivery are also addressed.The authors acknowledge the sponsorship received from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, co-financed by FEDER, under the Partnership Agreement PT2020 for the project UIDB/04469/2020 (strategic fund) granted to EBS, the National Council for Scientific and Technological Development (CNPq), Brazil, for the project 425271/2016-1 granted to M.V.C., and the Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES) and Fundação de Ámparo à Pesquisa do Estado de Sergipe (FAPITEC) (88887.159533/2017-00), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq301964/2019-0 Chamada 06/2019, and Chamada CNPq nº 01/2019), granted to P.S.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoZielinska, AleksandraSoles, Beatriz B.Lopes, Ana R.Vaz, Beatriz F.Rodrigues, Camila M.Alves, Thais F. R.Klensporf-Pawlik, DorotaDurazzo, AlessandraLucarini, MassimoSeverino, PatriciaSantini, AntonelloChaud, Marco V.Souto, Eliana B.20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/67673engZielinska, Aleksandra; Soles, Beatriz B.; Lopes, Ana R.; Vaz, Beatriz F.; Rodrigues, Camila M.; Alves, Thais F. R.; Klensporf-Pawlik, Dorota; Durazzo, Alessandra; Lucarini, Massimo; Severino, Patricia; Santini, Antonello; Chaud, Marco V.; Souto, Eliana, Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications. Biology, 9(10), 336, 20202079-773710.3390/biology9100336https://www.mdpi.com/2079-7737/9/10/336info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:52:14Zoai:repositorium.sdum.uminho.pt:1822/67673Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:51:19.490349Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications |
title |
Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications |
spellingShingle |
Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications Zielinska, Aleksandra eye administration ocular drug delivery nanopharmaceuticals ophthalmic treatments sterilization depyrogenation Science & Technology |
title_short |
Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications |
title_full |
Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications |
title_fullStr |
Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications |
title_full_unstemmed |
Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications |
title_sort |
Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications |
author |
Zielinska, Aleksandra |
author_facet |
Zielinska, Aleksandra Soles, Beatriz B. Lopes, Ana R. Vaz, Beatriz F. Rodrigues, Camila M. Alves, Thais F. R. Klensporf-Pawlik, Dorota Durazzo, Alessandra Lucarini, Massimo Severino, Patricia Santini, Antonello Chaud, Marco V. Souto, Eliana B. |
author_role |
author |
author2 |
Soles, Beatriz B. Lopes, Ana R. Vaz, Beatriz F. Rodrigues, Camila M. Alves, Thais F. R. Klensporf-Pawlik, Dorota Durazzo, Alessandra Lucarini, Massimo Severino, Patricia Santini, Antonello Chaud, Marco V. Souto, Eliana B. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Zielinska, Aleksandra Soles, Beatriz B. Lopes, Ana R. Vaz, Beatriz F. Rodrigues, Camila M. Alves, Thais F. R. Klensporf-Pawlik, Dorota Durazzo, Alessandra Lucarini, Massimo Severino, Patricia Santini, Antonello Chaud, Marco V. Souto, Eliana B. |
dc.subject.por.fl_str_mv |
eye administration ocular drug delivery nanopharmaceuticals ophthalmic treatments sterilization depyrogenation Science & Technology |
topic |
eye administration ocular drug delivery nanopharmaceuticals ophthalmic treatments sterilization depyrogenation Science & Technology |
description |
As an immune-privileged target organ, the eyes have important superficial and internal barriers, protecting them from physical and chemical damage from exogenous and/or endogenous origins that would cause injury to visual acuity or even vision loss. These anatomic, physiological and histologic barriers are thus a challenge for drug access and entry into the eye. Novel therapeutic concepts are highly desirable for eye treatment. The design of an efficient ocular drug delivery system still remains a challenge. Although nanotechnology may offer the ability to detect and treat eye diseases, successful treatment approaches are still in demand. The growing interest in nanopharmaceuticals offers the opportunity to improve ophthalmic treatments. Besides their size, which needs to be critically monitored, nanopharmaceuticals for ophthalmic applications have to be produced under sterilized conditions. In this work, we have revised the different sterilization and depyrogenation methods for ophthalmic nanopharmaceuticals with their merits and drawbacks. The paper also describes clinical sterilization of drugs and the outcomes of inappropriate practices, while recent applications of nanopharmaceuticals for ocular drug delivery are also addressed. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/67673 |
url |
http://hdl.handle.net/1822/67673 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Zielinska, Aleksandra; Soles, Beatriz B.; Lopes, Ana R.; Vaz, Beatriz F.; Rodrigues, Camila M.; Alves, Thais F. R.; Klensporf-Pawlik, Dorota; Durazzo, Alessandra; Lucarini, Massimo; Severino, Patricia; Santini, Antonello; Chaud, Marco V.; Souto, Eliana, Nanopharmaceuticals for eye administration: sterilization, depyrogenation and clinical applications. Biology, 9(10), 336, 2020 2079-7737 10.3390/biology9100336 https://www.mdpi.com/2079-7737/9/10/336 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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