Sustained drug release by contact lenses for glaucoma treatment - a review

Detalhes bibliográficos
Autor(a) principal: Carvalho, I.M.
Data de Publicação: 2015
Outros Autores: Marques, C.S., Oliveira, Rita, Barata, Pedro, Costa, P.C., Ferreira, D.C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/10668
Resumo: In the context of ocular pharmacology, there is a growing need for innovative delivery platforms for a convenient and sustained drug release into the eye, especially for chronic diseases that require the adoption of a strict insurmountable treatment regimen for a large part of the affected population, as in the case of glaucoma. Due to the large residence time of the contact lenses in the eye, its use for sustained drug delivery is quite promising. However, and despite the numerous therapeutic advantages arising from its use, the low affinity shown by most ophthalmic drugs for conventional contact lenses hinders the practical application of this technology. In this paper we elaborated a review of the various methods exploited so far to improve the contact lenses' characteristics as mechanisms for controlled and prolonged drug release for topical treatment of ocular diseases, with particular emphasis on the treatment of glaucoma.
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spelling Sustained drug release by contact lenses for glaucoma treatment - a reviewContact lensesNanoparticlesOphthalmicOcular deliveryGlaucomaIn the context of ocular pharmacology, there is a growing need for innovative delivery platforms for a convenient and sustained drug release into the eye, especially for chronic diseases that require the adoption of a strict insurmountable treatment regimen for a large part of the affected population, as in the case of glaucoma. Due to the large residence time of the contact lenses in the eye, its use for sustained drug delivery is quite promising. However, and despite the numerous therapeutic advantages arising from its use, the low affinity shown by most ophthalmic drugs for conventional contact lenses hinders the practical application of this technology. In this paper we elaborated a review of the various methods exploited so far to improve the contact lenses' characteristics as mechanisms for controlled and prolonged drug release for topical treatment of ocular diseases, with particular emphasis on the treatment of glaucoma.ElsevierRepositório Institucional da Universidade Fernando PessoaCarvalho, I.M.Marques, C.S.Oliveira, RitaBarata, PedroCosta, P.C.Ferreira, D.C.2022-01-27T11:58:19Z2015-01-01T00:00:00Z2015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/10668eng0168-365910.1016/j.jconrel.2015.01.023metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:09:56Zoai:bdigital.ufp.pt:10284/10668Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:47:25.888534Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sustained drug release by contact lenses for glaucoma treatment - a review
title Sustained drug release by contact lenses for glaucoma treatment - a review
spellingShingle Sustained drug release by contact lenses for glaucoma treatment - a review
Carvalho, I.M.
Contact lenses
Nanoparticles
Ophthalmic
Ocular delivery
Glaucoma
title_short Sustained drug release by contact lenses for glaucoma treatment - a review
title_full Sustained drug release by contact lenses for glaucoma treatment - a review
title_fullStr Sustained drug release by contact lenses for glaucoma treatment - a review
title_full_unstemmed Sustained drug release by contact lenses for glaucoma treatment - a review
title_sort Sustained drug release by contact lenses for glaucoma treatment - a review
author Carvalho, I.M.
author_facet Carvalho, I.M.
Marques, C.S.
Oliveira, Rita
Barata, Pedro
Costa, P.C.
Ferreira, D.C.
author_role author
author2 Marques, C.S.
Oliveira, Rita
Barata, Pedro
Costa, P.C.
Ferreira, D.C.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv Carvalho, I.M.
Marques, C.S.
Oliveira, Rita
Barata, Pedro
Costa, P.C.
Ferreira, D.C.
dc.subject.por.fl_str_mv Contact lenses
Nanoparticles
Ophthalmic
Ocular delivery
Glaucoma
topic Contact lenses
Nanoparticles
Ophthalmic
Ocular delivery
Glaucoma
description In the context of ocular pharmacology, there is a growing need for innovative delivery platforms for a convenient and sustained drug release into the eye, especially for chronic diseases that require the adoption of a strict insurmountable treatment regimen for a large part of the affected population, as in the case of glaucoma. Due to the large residence time of the contact lenses in the eye, its use for sustained drug delivery is quite promising. However, and despite the numerous therapeutic advantages arising from its use, the low affinity shown by most ophthalmic drugs for conventional contact lenses hinders the practical application of this technology. In this paper we elaborated a review of the various methods exploited so far to improve the contact lenses' characteristics as mechanisms for controlled and prolonged drug release for topical treatment of ocular diseases, with particular emphasis on the treatment of glaucoma.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01T00:00:00Z
2015-01-01T00:00:00Z
2022-01-27T11:58:19Z
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10.1016/j.jconrel.2015.01.023
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