Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell lines

Detalhes bibliográficos
Autor(a) principal: Marcelo, Gonçalo
Data de Publicação: 2018
Outros Autores: Ariana-Machado, Jessica, Enea, Maria, Carmo, Helena, Rodríguez-González, Benito, Capelo, José Luis, Lodeiro, Carlos, Oliveira, Elisabete
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.3390/ma11081310
Resumo: This research was funded by the project MultiNANO@Tox, and by Scientific Society PROTEOMASS (General Funding Grant), Portugal.
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spelling Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell linesCytotoxicityDrug deliveryLuminescence mesoporous silica nanoparticlesMaterials Science(all)SDG 3 - Good Health and Well-beingThis research was funded by the project MultiNANO@Tox, and by Scientific Society PROTEOMASS (General Funding Grant), Portugal.Luminescent mesoporous silica nanoparticles, CdTeQDs@MNs@PEG1, SiQDs@Isoc@MNs and SiQDs@Isoc@MNs@PEG2, were successfully synthetized and characterized by SEM, TEM, XRD, N2 nitrogen isotherms, 1H NMR, IR, absorption, and emission spectroscopy. Cytotoxic evaluation of these nanoparticles was performed in relevant in vitro cell models, such as human hepatoma HepG2, human brain endothelial (hCMEC/D3), and human epithelial colorectal adenocarcinoma (Caco-2) cell lines. None of the tested nanoparticles showed significant cytotoxicity in any of the three performed assays (MTT/NR/ LDH) compared with the respective solvent and/or coating controls, excepting for CdTeQDs@MNs@PEG1 nanoparticles, where significant toxicity was noticed in hCMEC/D3 cells. The results presented reveal that SiQDs-based mesoporous silica nanoparticles are promising nanoplatforms for cancer treatment, with a pH-responsive drug release profile and the ability to load 80% of doxorubicin.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNMarcelo, GonçaloAriana-Machado, JessicaEnea, MariaCarmo, HelenaRodríguez-González, BenitoCapelo, José LuisLodeiro, CarlosOliveira, Elisabete2019-02-01T23:46:07Z2018-07-282018-07-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.3390/ma11081310eng1996-1944PURE: 5741134http://www.scopus.com/inward/record.url?scp=85051103029&partnerID=8YFLogxKhttps://doi.org/10.3390/ma11081310info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:28:30Zoai:run.unl.pt:10362/59318Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:33:22.508397Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell lines
title Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell lines
spellingShingle Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell lines
Marcelo, Gonçalo
Cytotoxicity
Drug delivery
Luminescence mesoporous silica nanoparticles
Materials Science(all)
SDG 3 - Good Health and Well-being
title_short Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell lines
title_full Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell lines
title_fullStr Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell lines
title_full_unstemmed Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell lines
title_sort Toxicological evaluation of luminescent silica nanoparticles as new drug nanocarriers in different cancer cell lines
author Marcelo, Gonçalo
author_facet Marcelo, Gonçalo
Ariana-Machado, Jessica
Enea, Maria
Carmo, Helena
Rodríguez-González, Benito
Capelo, José Luis
Lodeiro, Carlos
Oliveira, Elisabete
author_role author
author2 Ariana-Machado, Jessica
Enea, Maria
Carmo, Helena
Rodríguez-González, Benito
Capelo, José Luis
Lodeiro, Carlos
Oliveira, Elisabete
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Marcelo, Gonçalo
Ariana-Machado, Jessica
Enea, Maria
Carmo, Helena
Rodríguez-González, Benito
Capelo, José Luis
Lodeiro, Carlos
Oliveira, Elisabete
dc.subject.por.fl_str_mv Cytotoxicity
Drug delivery
Luminescence mesoporous silica nanoparticles
Materials Science(all)
SDG 3 - Good Health and Well-being
topic Cytotoxicity
Drug delivery
Luminescence mesoporous silica nanoparticles
Materials Science(all)
SDG 3 - Good Health and Well-being
description This research was funded by the project MultiNANO@Tox, and by Scientific Society PROTEOMASS (General Funding Grant), Portugal.
publishDate 2018
dc.date.none.fl_str_mv 2018-07-28
2018-07-28T00:00:00Z
2019-02-01T23:46:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.3390/ma11081310
url https://doi.org/10.3390/ma11081310
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1996-1944
PURE: 5741134
http://www.scopus.com/inward/record.url?scp=85051103029&partnerID=8YFLogxK
https://doi.org/10.3390/ma11081310
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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