Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/107167 https://doi.org/10.1186/s13039-019-0447-z |
Resumo: | Head and neck squamous cell carcinoma (HNSCC) affects multiple sites of the upper aerodigestive tract and exhibited high incidence and mortality worldwide, being frequently diagnosed at advanced stage. Early detection of HNSCC plays a crucial role in a successful therapy. In the last years, the survival rates of these tumors have not improved significantly due to the late diagnosis and the lack of precise disease biomarkers and targeted therapies. The introduction in the clinical practice of body fluids to detect and analyze circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and exosomes provides a minimally or non-invasive method also called as liquid biopsy for diagnostic and prognostic biomarkers detection, representing a shift of paradigm in precision medicine through the revolution in the way to perform HNSCC diagnosis and to screen high risk population. Despite the use of body fluids being an emergent and up-to date issue to early diagnosis HNSCC and their recurrences, no strategy has yet proven to be consistently effective and able to be translated to clinical application in the routine clinical management of these patients. In this review we will discuss the recent discoveries using blood and saliva to identify biomarkers for the early detection and prognosis of HNSCC. |
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Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of artBody fluidsCell-free DNACirculating tumor DNAExosomesHead and neck cancerHead and neck squamous cell carcinoma (HNSCC) affects multiple sites of the upper aerodigestive tract and exhibited high incidence and mortality worldwide, being frequently diagnosed at advanced stage. Early detection of HNSCC plays a crucial role in a successful therapy. In the last years, the survival rates of these tumors have not improved significantly due to the late diagnosis and the lack of precise disease biomarkers and targeted therapies. The introduction in the clinical practice of body fluids to detect and analyze circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and exosomes provides a minimally or non-invasive method also called as liquid biopsy for diagnostic and prognostic biomarkers detection, representing a shift of paradigm in precision medicine through the revolution in the way to perform HNSCC diagnosis and to screen high risk population. Despite the use of body fluids being an emergent and up-to date issue to early diagnosis HNSCC and their recurrences, no strategy has yet proven to be consistently effective and able to be translated to clinical application in the routine clinical management of these patients. In this review we will discuss the recent discoveries using blood and saliva to identify biomarkers for the early detection and prognosis of HNSCC.Springer Nature2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107167http://hdl.handle.net/10316/107167https://doi.org/10.1186/s13039-019-0447-zeng1755-8166Ribeiro, Ilda PatríciaMelo, Joana Barbosa deCarreira, Isabel Marquesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-13T08:19:42Zoai:estudogeral.uc.pt:10316/107167Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:31.659895Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art |
title |
Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art |
spellingShingle |
Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art Ribeiro, Ilda Patrícia Body fluids Cell-free DNA Circulating tumor DNA Exosomes Head and neck cancer |
title_short |
Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art |
title_full |
Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art |
title_fullStr |
Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art |
title_full_unstemmed |
Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art |
title_sort |
Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids - the state of art |
author |
Ribeiro, Ilda Patrícia |
author_facet |
Ribeiro, Ilda Patrícia Melo, Joana Barbosa de Carreira, Isabel Marques |
author_role |
author |
author2 |
Melo, Joana Barbosa de Carreira, Isabel Marques |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Ribeiro, Ilda Patrícia Melo, Joana Barbosa de Carreira, Isabel Marques |
dc.subject.por.fl_str_mv |
Body fluids Cell-free DNA Circulating tumor DNA Exosomes Head and neck cancer |
topic |
Body fluids Cell-free DNA Circulating tumor DNA Exosomes Head and neck cancer |
description |
Head and neck squamous cell carcinoma (HNSCC) affects multiple sites of the upper aerodigestive tract and exhibited high incidence and mortality worldwide, being frequently diagnosed at advanced stage. Early detection of HNSCC plays a crucial role in a successful therapy. In the last years, the survival rates of these tumors have not improved significantly due to the late diagnosis and the lack of precise disease biomarkers and targeted therapies. The introduction in the clinical practice of body fluids to detect and analyze circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and exosomes provides a minimally or non-invasive method also called as liquid biopsy for diagnostic and prognostic biomarkers detection, representing a shift of paradigm in precision medicine through the revolution in the way to perform HNSCC diagnosis and to screen high risk population. Despite the use of body fluids being an emergent and up-to date issue to early diagnosis HNSCC and their recurrences, no strategy has yet proven to be consistently effective and able to be translated to clinical application in the routine clinical management of these patients. In this review we will discuss the recent discoveries using blood and saliva to identify biomarkers for the early detection and prognosis of HNSCC. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/107167 http://hdl.handle.net/10316/107167 https://doi.org/10.1186/s13039-019-0447-z |
url |
http://hdl.handle.net/10316/107167 https://doi.org/10.1186/s13039-019-0447-z |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1755-8166 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134122198695936 |