Localized therapeutic approaches based on micro/nanofibers for cancer treatment
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/85516 |
Resumo: | Cancer remains one of the most challenging health problems worldwide, and localized therapeutic approaches based on micro/nanofibers have shown potential for its treatment. Micro/nanofibers offer several advantages as a drug delivery system, such as high surface area, tunable pore size, and sustained release properties, which can improve drug efficacy and reduce side effects. In addition, functionalization of these fibers with nanoparticles can enhance their targeting and therapeutic capabilities. Localized delivery of drugs and/or other therapeutic agents via micro/nanofibers can also help to overcome the limitations of systemic administration, such as poor bioavailability and off-target effects. Several studies have shown promising results in preclinical models of cancer, including inhibition of tumor growth and improved survival rates. However, more research is needed to overcome technical and regulatory challenges to bring these approaches to clinical use. Localized therapeutic approaches based on micro/nanofibers hold great promise for the future of cancer treatment, providing a targeted, effective, and minimally invasive alternative to traditional treatments. The main focus of this review is to explore the current treatments utilizing micro/nanofibers, as well as localized drug delivery systems that rely on fibrous structures to deliver and release drugs for the treatment of cancer in a specific area. |
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Localized therapeutic approaches based on micro/nanofibers for cancer treatmentCancerDrug delivery systemNanofibersNanoparticlesTheragnosticEngenharia e Tecnologia::Outras Engenharias e TecnologiasScience & TechnologyCancer remains one of the most challenging health problems worldwide, and localized therapeutic approaches based on micro/nanofibers have shown potential for its treatment. Micro/nanofibers offer several advantages as a drug delivery system, such as high surface area, tunable pore size, and sustained release properties, which can improve drug efficacy and reduce side effects. In addition, functionalization of these fibers with nanoparticles can enhance their targeting and therapeutic capabilities. Localized delivery of drugs and/or other therapeutic agents via micro/nanofibers can also help to overcome the limitations of systemic administration, such as poor bioavailability and off-target effects. Several studies have shown promising results in preclinical models of cancer, including inhibition of tumor growth and improved survival rates. However, more research is needed to overcome technical and regulatory challenges to bring these approaches to clinical use. Localized therapeutic approaches based on micro/nanofibers hold great promise for the future of cancer treatment, providing a targeted, effective, and minimally invasive alternative to traditional treatments. The main focus of this review is to explore the current treatments utilizing micro/nanofibers, as well as localized drug delivery systems that rely on fibrous structures to deliver and release drugs for the treatment of cancer in a specific area.The authors are thankful to project UID/CTM/00264/2022 of 2C2T—Centro de Ciência e Tecnologia Têxtil, funded by National Funds through FCT/MCTES and to the FCT-Fundação para a Ciência e a Tecnologia Ph.D. Scholarship (grant number SFRH/BD/147812/2019) of Joana C. Araújo. Diana P. Ferreira is thankful to CEECIND/02803/2017.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoAlves, Diana Isabel SousaAraújo, Joana Carolina CarvalhoFangueiro, RaúlFerreira, Diana P.2023-03-292023-03-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/85516engAlves, D.; Araújo, J.C.; Fangueiro, R.; Ferreira, D.P. Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment. Molecules 2023, 28, 3053. https://doi.org/10.3390/molecules280730531420-304910.3390/molecules28073053https://www.mdpi.com/1420-3049/28/7/3053info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-23T01:31:12Zoai:repositorium.sdum.uminho.pt:1822/85516Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:18:48.896687Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Localized therapeutic approaches based on micro/nanofibers for cancer treatment |
title |
Localized therapeutic approaches based on micro/nanofibers for cancer treatment |
spellingShingle |
Localized therapeutic approaches based on micro/nanofibers for cancer treatment Alves, Diana Isabel Sousa Cancer Drug delivery system Nanofibers Nanoparticles Theragnostic Engenharia e Tecnologia::Outras Engenharias e Tecnologias Science & Technology |
title_short |
Localized therapeutic approaches based on micro/nanofibers for cancer treatment |
title_full |
Localized therapeutic approaches based on micro/nanofibers for cancer treatment |
title_fullStr |
Localized therapeutic approaches based on micro/nanofibers for cancer treatment |
title_full_unstemmed |
Localized therapeutic approaches based on micro/nanofibers for cancer treatment |
title_sort |
Localized therapeutic approaches based on micro/nanofibers for cancer treatment |
author |
Alves, Diana Isabel Sousa |
author_facet |
Alves, Diana Isabel Sousa Araújo, Joana Carolina Carvalho Fangueiro, Raúl Ferreira, Diana P. |
author_role |
author |
author2 |
Araújo, Joana Carolina Carvalho Fangueiro, Raúl Ferreira, Diana P. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Alves, Diana Isabel Sousa Araújo, Joana Carolina Carvalho Fangueiro, Raúl Ferreira, Diana P. |
dc.subject.por.fl_str_mv |
Cancer Drug delivery system Nanofibers Nanoparticles Theragnostic Engenharia e Tecnologia::Outras Engenharias e Tecnologias Science & Technology |
topic |
Cancer Drug delivery system Nanofibers Nanoparticles Theragnostic Engenharia e Tecnologia::Outras Engenharias e Tecnologias Science & Technology |
description |
Cancer remains one of the most challenging health problems worldwide, and localized therapeutic approaches based on micro/nanofibers have shown potential for its treatment. Micro/nanofibers offer several advantages as a drug delivery system, such as high surface area, tunable pore size, and sustained release properties, which can improve drug efficacy and reduce side effects. In addition, functionalization of these fibers with nanoparticles can enhance their targeting and therapeutic capabilities. Localized delivery of drugs and/or other therapeutic agents via micro/nanofibers can also help to overcome the limitations of systemic administration, such as poor bioavailability and off-target effects. Several studies have shown promising results in preclinical models of cancer, including inhibition of tumor growth and improved survival rates. However, more research is needed to overcome technical and regulatory challenges to bring these approaches to clinical use. Localized therapeutic approaches based on micro/nanofibers hold great promise for the future of cancer treatment, providing a targeted, effective, and minimally invasive alternative to traditional treatments. The main focus of this review is to explore the current treatments utilizing micro/nanofibers, as well as localized drug delivery systems that rely on fibrous structures to deliver and release drugs for the treatment of cancer in a specific area. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-29 2023-03-29T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/85516 |
url |
https://hdl.handle.net/1822/85516 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Alves, D.; Araújo, J.C.; Fangueiro, R.; Ferreira, D.P. Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment. Molecules 2023, 28, 3053. https://doi.org/10.3390/molecules28073053 1420-3049 10.3390/molecules28073053 https://www.mdpi.com/1420-3049/28/7/3053 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132644853678080 |