Diabetic retinopathy and ocular melanoma: how far we are?
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/65100 |
Resumo: | Diabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal melanoma is an eye tumour that remains highly deadly, because despite the correct treatment, it still causes metastasis in about 50% of patients. This type of tumour has the ability to produce and store melanin, which may result in resistance to therapy. Over time there has been development of new therapies for this disease, such as radiotherapy and surgical resection. In this review, we discuss diabetic retinopathy and ocular melanoma, their relationship with angiogenesis and the current anti-angiogenic therapies for their treatment. |
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Diabetic retinopathy and ocular melanoma: how far we are?angiogenesisvascular endothelial growth factorinflammationdiabetic retinopathyuveal melanomaanti-angiogenic therapyScience & TechnologyDiabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal melanoma is an eye tumour that remains highly deadly, because despite the correct treatment, it still causes metastasis in about 50% of patients. This type of tumour has the ability to produce and store melanin, which may result in resistance to therapy. Over time there has been development of new therapies for this disease, such as radiotherapy and surgical resection. In this review, we discuss diabetic retinopathy and ocular melanoma, their relationship with angiogenesis and the current anti-angiogenic therapies for their treatment.The authors acknowledge the financial support received from the Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project references M-ERANET/0004/2015-PAIRED, UIDB/04469/2020 (strategic fund) and UID/AGR/04033/2019 (CITAB), co-financed by FEDER, under the Partnership Agreement PT2020. The authors also acknowledge the support of the research project: Nutraceutica come supporto nutrizionale nel paziente oncologico, CUP: B83D18000140007.info:eu-repo/semantics/publishedVersionMDPI AGUniversidade do MinhoSouto, Eliana B.Campos, Joana R.Da Ana, RaquelFangueiro, Joana F.Martins-Gomes, CarlosDurazzo, AlessandraLucarini, MassimoLópez, Elena SánchezEspina, MartaGarcía, Maria LuisaSilva, Amélia M.Mendonça, FernandoSantini, AntonelloSouto, Selma B.2020-04-162020-04-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/65100engSouto, Eliana; Campos, Joana R.; Da Ana, Raquel; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, Massimo; López, Elena Sánchez; Espina, Marta; García, Maria Luisa; Silva, Amélia M.; Mendonça, Fernando; Santini, Antonello; Souto, Selma B., Diabetic retinopathy and ocular melanoma: how far we are?. Applied Sciences-Basel, 10(8), 2777, 20202076-341710.3390/app10082777http://www.mdpi.com/journal/applsciinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:53:53Zoai:repositorium.sdum.uminho.pt:1822/65100Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:53:22.066402Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Diabetic retinopathy and ocular melanoma: how far we are? |
title |
Diabetic retinopathy and ocular melanoma: how far we are? |
spellingShingle |
Diabetic retinopathy and ocular melanoma: how far we are? Souto, Eliana B. angiogenesis vascular endothelial growth factor inflammation diabetic retinopathy uveal melanoma anti-angiogenic therapy Science & Technology |
title_short |
Diabetic retinopathy and ocular melanoma: how far we are? |
title_full |
Diabetic retinopathy and ocular melanoma: how far we are? |
title_fullStr |
Diabetic retinopathy and ocular melanoma: how far we are? |
title_full_unstemmed |
Diabetic retinopathy and ocular melanoma: how far we are? |
title_sort |
Diabetic retinopathy and ocular melanoma: how far we are? |
author |
Souto, Eliana B. |
author_facet |
Souto, Eliana B. Campos, Joana R. Da Ana, Raquel Fangueiro, Joana F. Martins-Gomes, Carlos Durazzo, Alessandra Lucarini, Massimo López, Elena Sánchez Espina, Marta García, Maria Luisa Silva, Amélia M. Mendonça, Fernando Santini, Antonello Souto, Selma B. |
author_role |
author |
author2 |
Campos, Joana R. Da Ana, Raquel Fangueiro, Joana F. Martins-Gomes, Carlos Durazzo, Alessandra Lucarini, Massimo López, Elena Sánchez Espina, Marta García, Maria Luisa Silva, Amélia M. Mendonça, Fernando Santini, Antonello Souto, Selma B. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Souto, Eliana B. Campos, Joana R. Da Ana, Raquel Fangueiro, Joana F. Martins-Gomes, Carlos Durazzo, Alessandra Lucarini, Massimo López, Elena Sánchez Espina, Marta García, Maria Luisa Silva, Amélia M. Mendonça, Fernando Santini, Antonello Souto, Selma B. |
dc.subject.por.fl_str_mv |
angiogenesis vascular endothelial growth factor inflammation diabetic retinopathy uveal melanoma anti-angiogenic therapy Science & Technology |
topic |
angiogenesis vascular endothelial growth factor inflammation diabetic retinopathy uveal melanoma anti-angiogenic therapy Science & Technology |
description |
Diabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal melanoma is an eye tumour that remains highly deadly, because despite the correct treatment, it still causes metastasis in about 50% of patients. This type of tumour has the ability to produce and store melanin, which may result in resistance to therapy. Over time there has been development of new therapies for this disease, such as radiotherapy and surgical resection. In this review, we discuss diabetic retinopathy and ocular melanoma, their relationship with angiogenesis and the current anti-angiogenic therapies for their treatment. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04-16 2020-04-16T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/65100 |
url |
http://hdl.handle.net/1822/65100 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Souto, Eliana; Campos, Joana R.; Da Ana, Raquel; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, Massimo; López, Elena Sánchez; Espina, Marta; García, Maria Luisa; Silva, Amélia M.; Mendonça, Fernando; Santini, Antonello; Souto, Selma B., Diabetic retinopathy and ocular melanoma: how far we are?. Applied Sciences-Basel, 10(8), 2777, 2020 2076-3417 10.3390/app10082777 http://www.mdpi.com/journal/applsci |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI AG |
publisher.none.fl_str_mv |
MDPI AG |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133129338781696 |