Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012
| Autor(a) principal: | |
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| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/62087 |
Resumo: | © 2014 Palladino et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012© 2014 Palladino et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Objectives To investigate the duration of sequential HAART regimens and predictors of first-line regimen discontinuation among HIV-1 vertically infected children and adolescents. Design Multicentre survey of antiretroviral-naïve patients enrolled in the HIV-Paediatric Cohor,t CoRISpeS-Madrid Cohort, Spain. Methods Patients with a follow-up of ≥1 month spent on HAART, with available baseline CD4 count and HIV-viral load (VL) were included. Time spent on sequential HAART regimens was estimated and multivariable regression was used to identify predictors of time to first-line regimen discontinuation. Results 104 patients were followed for a median 8 years after starting HAART among 1996–2012; baseline %CD4 was 21.5 (12.3–34.0)and viral load was 5.1 (4.6–5.6) log10 copies/mL. Patients received a mean of 1.9 regimens. Median time on first-line HAART (n = 104) was 64.5 months; second HAART (n = 56) 69.8 months; and third HAART (n = 21) 66.5 months. Eleven (11%) patients were lost to follow-up while on first-line HAART and 54% discontinued (cumulative incidence of 16% and 38% by 1 and 3-year, respectively). The main predictor of first-line regimen discontinuation was suboptimal adherence to antiretrovirals (AHR: 2.60; 95% CI: 1.44–4.70). Conclusions Adherence to therapy was the main determinant of the duration of the first-line HAART regimen in children. It is important to identify patients at high risk for non-adherence, such as very young children and adolescents, in provide special care and support to those patients.This work was supported by grants provided by the Fondo de Investigación de Sanidad en España (FIS) [grant numbers PI11-00888, PS09/02029, and PI13/02016], Red Española de Investigación en SIDA (RIS) [grant numbers RETIC RD06/0006/0035 RD12-0017-0037; RD06/0006/0021, RD12/0017/0029 and RD09/0076/00103], “Fundación para la Investigación y la Prevención del Sida en España” (FIPSE), Comunidad de Madrid [grant numbers, S-2010/BMD-2351, S-2010/BMD-2332], PENTA and Fundación Eugenio Rodríguez Pascual and grants PTDC/SAU-FAR/115290/2009 and PTDC/SAU-EPI/122400/2010 from Fundação para a Ciência e Tecnologia (FCT) (http://www.fct.pt), Portugal. Claudia Palladino is supported by the Portuguese Fundação para a Ciência e Tecnologia (FCT) (SFRH/BPD/77448/2011). Verónica Briz is supported by the Spanish Fondo de Investigación Sanitaria (Sara Borrell CD09/00433. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.PLoSRepositório da Universidade de LisboaPalladino, ClaudiaBriz, VerónicaBellón, José MaríaCliment, Francisco J.De Ory, Santiago J.Mellado, María JoséNavarro, María LuisaRamos, José T.Taveira, NunoDe José, María IsabelMuñoz-Fernández, María ÁngelesCoRISpeS-Madrid Cohort Working Group2024-01-24T19:11:48Z20142023-02-09T15:17:38Z2014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/62087engPalladino C, Briz V, Bellón JM, Climent FJ, De Ory SJ, Mellado MJ, et al. Determinants of highly active antiretroviral therapy duration in hiv-1-infected children and adolescents in madrid, spain, from 1996 to 2012. He W, editor. PLoS ONE [Internet]. 1 de maio de 2014;9(5):e96307. Disponível em: https://dx.plos.org/10.1371/journal.pone.0096307cv-prod-118553210.1371/journal.pone.00963072-s2.0-84900338272info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-29T01:19:33Zoai:repositorio.ul.pt:10451/62087Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:58:28.925399Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| spellingShingle |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 Palladino, Claudia |
| title_short |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title_full |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title_fullStr |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title_full_unstemmed |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| title_sort |
Determinants of highly active antiretroviral therapy duration in HIV-1-infected children and adolescents in Madrid, Spain, from 1996 to 2012 |
| author |
Palladino, Claudia |
| author_facet |
Palladino, Claudia Briz, Verónica Bellón, José María Climent, Francisco J. De Ory, Santiago J. Mellado, María José Navarro, María Luisa Ramos, José T. Taveira, Nuno De José, María Isabel Muñoz-Fernández, María Ángeles CoRISpeS-Madrid Cohort Working Group |
| author_role |
author |
| author2 |
Briz, Verónica Bellón, José María Climent, Francisco J. De Ory, Santiago J. Mellado, María José Navarro, María Luisa Ramos, José T. Taveira, Nuno De José, María Isabel Muñoz-Fernández, María Ángeles CoRISpeS-Madrid Cohort Working Group |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Palladino, Claudia Briz, Verónica Bellón, José María Climent, Francisco J. De Ory, Santiago J. Mellado, María José Navarro, María Luisa Ramos, José T. Taveira, Nuno De José, María Isabel Muñoz-Fernández, María Ángeles CoRISpeS-Madrid Cohort Working Group |
| description |
© 2014 Palladino et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z 2023-02-09T15:17:38Z 2024-01-24T19:11:48Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/62087 |
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http://hdl.handle.net/10451/62087 |
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eng |
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eng |
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Palladino C, Briz V, Bellón JM, Climent FJ, De Ory SJ, Mellado MJ, et al. Determinants of highly active antiretroviral therapy duration in hiv-1-infected children and adolescents in madrid, spain, from 1996 to 2012. He W, editor. PLoS ONE [Internet]. 1 de maio de 2014;9(5):e96307. Disponível em: https://dx.plos.org/10.1371/journal.pone.0096307 cv-prod-1185532 10.1371/journal.pone.0096307 2-s2.0-84900338272 |
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PLoS |
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