In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibres

Detalhes bibliográficos
Autor(a) principal: Nabais, Joao
Data de Publicação: 2008
Outros Autores: Carrott, Peter, Ribeiro Carrott, Manuela, Mouquinho, Ana, Galacho, Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10174/2634
Resumo: We study the in vitro adsorption of fluoxetine hydrochloride by different adsorbents in simulated gastric and intestinal fluid, pH 1.2 and 7.5, respectively. The tested materials were two commercial activated carbons, carbomix and maxsorb MSC30, one activated carbon fibre produced in our laboratory and also three MCM-41 samples, also produced by us. Selected samples were modified by liquid phase oxidation and thermal treatment in order to change the surface chemistry without significant modifications to the porous characteristics. The fluoxetine adsorption follows the Langmuir model. The calculated Q0 values range from 54 to 1112 mg/g. A different adsorption mechanism was found for the adsorption of fluoxetine in activated carbon fibres and activated carbons. In the first case the most relevant factors are the molecular sieving effect and the dispersive interactions whereas in the activated carbons the mechanism seams to be based on the electrostatic interactions between the fluoxetine molecules and the charged carbon surface. Despite the different behaviours most of the materials tested have potential for treating potential fluoxetine intoxications.
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spelling In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibresFluoxetine adsorptionActivated carbonWe study the in vitro adsorption of fluoxetine hydrochloride by different adsorbents in simulated gastric and intestinal fluid, pH 1.2 and 7.5, respectively. The tested materials were two commercial activated carbons, carbomix and maxsorb MSC30, one activated carbon fibre produced in our laboratory and also three MCM-41 samples, also produced by us. Selected samples were modified by liquid phase oxidation and thermal treatment in order to change the surface chemistry without significant modifications to the porous characteristics. The fluoxetine adsorption follows the Langmuir model. The calculated Q0 values range from 54 to 1112 mg/g. A different adsorption mechanism was found for the adsorption of fluoxetine in activated carbon fibres and activated carbons. In the first case the most relevant factors are the molecular sieving effect and the dispersive interactions whereas in the activated carbons the mechanism seams to be based on the electrostatic interactions between the fluoxetine molecules and the charged carbon surface. Despite the different behaviours most of the materials tested have potential for treating potential fluoxetine intoxications.2011-03-16T10:22:11Z2011-03-162008-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article43637 bytesapplication/pdfhttp://hdl.handle.net/10174/2634http://hdl.handle.net/10174/2634eng549-555Fuel Processing and Technology89livreCQEjvn@uevora.ptpeter@uevora.ptmanrc@uevora.ptndpcg@uevora.pt252Nabais, JoaoCarrott, PeterRibeiro Carrott, ManuelaMouquinho, AnaGalacho, Cristinainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:36:42Zoai:dspace.uevora.pt:10174/2634Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:57:08.852638Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibres
title In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibres
spellingShingle In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibres
Nabais, Joao
Fluoxetine adsorption
Activated carbon
title_short In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibres
title_full In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibres
title_fullStr In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibres
title_full_unstemmed In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibres
title_sort In vitro adsorption study of fluoxetine in activated carbons and activated carbon fibres
author Nabais, Joao
author_facet Nabais, Joao
Carrott, Peter
Ribeiro Carrott, Manuela
Mouquinho, Ana
Galacho, Cristina
author_role author
author2 Carrott, Peter
Ribeiro Carrott, Manuela
Mouquinho, Ana
Galacho, Cristina
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nabais, Joao
Carrott, Peter
Ribeiro Carrott, Manuela
Mouquinho, Ana
Galacho, Cristina
dc.subject.por.fl_str_mv Fluoxetine adsorption
Activated carbon
topic Fluoxetine adsorption
Activated carbon
description We study the in vitro adsorption of fluoxetine hydrochloride by different adsorbents in simulated gastric and intestinal fluid, pH 1.2 and 7.5, respectively. The tested materials were two commercial activated carbons, carbomix and maxsorb MSC30, one activated carbon fibre produced in our laboratory and also three MCM-41 samples, also produced by us. Selected samples were modified by liquid phase oxidation and thermal treatment in order to change the surface chemistry without significant modifications to the porous characteristics. The fluoxetine adsorption follows the Langmuir model. The calculated Q0 values range from 54 to 1112 mg/g. A different adsorption mechanism was found for the adsorption of fluoxetine in activated carbon fibres and activated carbons. In the first case the most relevant factors are the molecular sieving effect and the dispersive interactions whereas in the activated carbons the mechanism seams to be based on the electrostatic interactions between the fluoxetine molecules and the charged carbon surface. Despite the different behaviours most of the materials tested have potential for treating potential fluoxetine intoxications.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01T00:00:00Z
2011-03-16T10:22:11Z
2011-03-16
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/2634
http://hdl.handle.net/10174/2634
url http://hdl.handle.net/10174/2634
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 549-555
Fuel Processing and Technology
89
livre
CQE
jvn@uevora.pt
peter@uevora.pt
manrc@uevora.pt
nd
pcg@uevora.pt
252
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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