Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet production

Detalhes bibliográficos
Autor(a) principal: Costa, Nuno F. da
Data de Publicação: 2021
Outros Autores: Pinto, João F., Fernandes, Ana Isabel
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/40563
Resumo: Communication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health and Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.
id RCAP_6c924f1fbe35986c7159913028ad6765
oai_identifier_str oai:comum.rcaap.pt:10400.26/40563
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet productionCo-amorphousCohesivenessDissolutionOlanzapineTabletsTensile strengthCommunication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health and Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The evaluation of the processability of co-amorphous mixtures is of paramount importance since these systems are increasingly used to address the poor solubility presented by most of the drugs in research and development. This work shows that co-amorphous olanzapine powders present higher cohesiveness than their crystalline counterpart and resulted in the production of tablets with a higher tensile strength and a slower release of the drug. As a result, this work demonstrates that despite the solubility advantages of co-amorphous mixtures, consideration should be given to the downstream processing of formulations containing such materials.MDPIRepositório ComumCosta, Nuno F. daPinto, João F.Fernandes, Ana Isabel2022-05-16T11:43:44Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10400.26/40563engda Costa NF, Pinto JF, Fernandes AI. Cohesiveness of Powdered Co-Amorphous Olanzapine and Impact on Tablet Production. Medical Sciences Forum. 2021; 5(1):2. https://doi.org/10.3390/msf2021005002978-3-0365-2238-82673-999210.3390/msf2021005002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-07T11:18:44Zoai:comum.rcaap.pt:10400.26/40563Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-07T11:18:44Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet production
title Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet production
spellingShingle Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet production
Costa, Nuno F. da
Co-amorphous
Cohesiveness
Dissolution
Olanzapine
Tablets
Tensile strength
title_short Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet production
title_full Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet production
title_fullStr Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet production
title_full_unstemmed Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet production
title_sort Cohesiveness of powdered co-amorphous Olanzapine and impact on tablet production
author Costa, Nuno F. da
author_facet Costa, Nuno F. da
Pinto, João F.
Fernandes, Ana Isabel
author_role author
author2 Pinto, João F.
Fernandes, Ana Isabel
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Costa, Nuno F. da
Pinto, João F.
Fernandes, Ana Isabel
dc.subject.por.fl_str_mv Co-amorphous
Cohesiveness
Dissolution
Olanzapine
Tablets
Tensile strength
topic Co-amorphous
Cohesiveness
Dissolution
Olanzapine
Tablets
Tensile strength
description Communication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health and Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-05-16T11:43:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/40563
url http://hdl.handle.net/10400.26/40563
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv da Costa NF, Pinto JF, Fernandes AI. Cohesiveness of Powdered Co-Amorphous Olanzapine and Impact on Tablet Production. Medical Sciences Forum. 2021; 5(1):2. https://doi.org/10.3390/msf2021005002
978-3-0365-2238-8
2673-9992
10.3390/msf2021005002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817544167888257024

Registros relacionados