The prefrontal cortex as a key target of the maladaptive response to stress

Detalhes bibliográficos
Autor(a) principal: Cerqueira, João José
Data de Publicação: 2007
Outros Autores: Mailliet, François, Almeida, Osborne F. X., Jay, Thérèse M., Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/64284
Resumo: Research on the detrimental effects of stress in the brain has mainly focused on the hippocampus. Because prefrontal cortex (PFC) dysfunction characterizes many stress-related disorders, we here analyzed the impact of chronic stress in rats on the integrity of the hippocampal-PFC pathway, monitored by behavioral and electrophysiological function and morphological assessment. We show that chronic stress impairs synaptic plasticity by reducing LTP induction in the hippocampal-PFC connection; in addition, it induces selective atrophy within the PFC and severely disrupts working memory and behavioral flexibility, two functions that depend on PFC integrity. We also demonstrate that short periods of stress exposure induce spatial reference memory deficits before affecting PFC-dependent tasks, thus suggesting that the impairment of synaptic plasticity within the hippocampus-to-PFC connection is of relevance to the stress-induced PFC dysfunction. These findings evidence a fundamental role of the PFC in maladaptive responses to stress and identify this area as a target for intervention in stress-related disorders.
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spelling The prefrontal cortex as a key target of the maladaptive response to stressAnimalsHippocampusMaleMemoryMemory disordersNeural pathwaysNeuronal plasticityPrefrontal cortexRatsRats, wistarStress, physiologicalplasticitystereologyworking memoryLTPchronic stressratScience & TechnologyResearch on the detrimental effects of stress in the brain has mainly focused on the hippocampus. Because prefrontal cortex (PFC) dysfunction characterizes many stress-related disorders, we here analyzed the impact of chronic stress in rats on the integrity of the hippocampal-PFC pathway, monitored by behavioral and electrophysiological function and morphological assessment. We show that chronic stress impairs synaptic plasticity by reducing LTP induction in the hippocampal-PFC connection; in addition, it induces selective atrophy within the PFC and severely disrupts working memory and behavioral flexibility, two functions that depend on PFC integrity. We also demonstrate that short periods of stress exposure induce spatial reference memory deficits before affecting PFC-dependent tasks, thus suggesting that the impairment of synaptic plasticity within the hippocampus-to-PFC connection is of relevance to the stress-induced PFC dysfunction. These findings evidence a fundamental role of the PFC in maladaptive responses to stress and identify this area as a target for intervention in stress-related disorders.This work was supported in part by an Acções Integradas Luso-Alemãs grant from the German Academic Exchange Service and the Portuguese Rectors’ Conference, and Mobility Grant 183/2006 from the Institut National de la Santé et de la RechercheMédicale andthe Cabinetfor International Relations ofthe PortugueseMinistry of Science and Higher Education.Society for NeuroscienceUniversidade do MinhoCerqueira, João JoséMailliet, FrançoisAlmeida, Osborne F. X.Jay, Thérèse M.Sousa, Nuno2007-03-142007-03-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/64284eng0270-64741529-240110.1523/JNEUROSCI.4372-06.200717360899https://www.jneurosci.org/content/27/11/2781info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:20:01Zoai:repositorium.sdum.uminho.pt:1822/64284Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:13:04.412167Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The prefrontal cortex as a key target of the maladaptive response to stress
title The prefrontal cortex as a key target of the maladaptive response to stress
spellingShingle The prefrontal cortex as a key target of the maladaptive response to stress
Cerqueira, João José
Animals
Hippocampus
Male
Memory
Memory disorders
Neural pathways
Neuronal plasticity
Prefrontal cortex
Rats
Rats, wistar
Stress, physiological
plasticity
stereology
working memory
LTP
chronic stress
rat
Science & Technology
title_short The prefrontal cortex as a key target of the maladaptive response to stress
title_full The prefrontal cortex as a key target of the maladaptive response to stress
title_fullStr The prefrontal cortex as a key target of the maladaptive response to stress
title_full_unstemmed The prefrontal cortex as a key target of the maladaptive response to stress
title_sort The prefrontal cortex as a key target of the maladaptive response to stress
author Cerqueira, João José
author_facet Cerqueira, João José
Mailliet, François
Almeida, Osborne F. X.
Jay, Thérèse M.
Sousa, Nuno
author_role author
author2 Mailliet, François
Almeida, Osborne F. X.
Jay, Thérèse M.
Sousa, Nuno
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Cerqueira, João José
Mailliet, François
Almeida, Osborne F. X.
Jay, Thérèse M.
Sousa, Nuno
dc.subject.por.fl_str_mv Animals
Hippocampus
Male
Memory
Memory disorders
Neural pathways
Neuronal plasticity
Prefrontal cortex
Rats
Rats, wistar
Stress, physiological
plasticity
stereology
working memory
LTP
chronic stress
rat
Science & Technology
topic Animals
Hippocampus
Male
Memory
Memory disorders
Neural pathways
Neuronal plasticity
Prefrontal cortex
Rats
Rats, wistar
Stress, physiological
plasticity
stereology
working memory
LTP
chronic stress
rat
Science & Technology
description Research on the detrimental effects of stress in the brain has mainly focused on the hippocampus. Because prefrontal cortex (PFC) dysfunction characterizes many stress-related disorders, we here analyzed the impact of chronic stress in rats on the integrity of the hippocampal-PFC pathway, monitored by behavioral and electrophysiological function and morphological assessment. We show that chronic stress impairs synaptic plasticity by reducing LTP induction in the hippocampal-PFC connection; in addition, it induces selective atrophy within the PFC and severely disrupts working memory and behavioral flexibility, two functions that depend on PFC integrity. We also demonstrate that short periods of stress exposure induce spatial reference memory deficits before affecting PFC-dependent tasks, thus suggesting that the impairment of synaptic plasticity within the hippocampus-to-PFC connection is of relevance to the stress-induced PFC dysfunction. These findings evidence a fundamental role of the PFC in maladaptive responses to stress and identify this area as a target for intervention in stress-related disorders.
publishDate 2007
dc.date.none.fl_str_mv 2007-03-14
2007-03-14T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/64284
url http://hdl.handle.net/1822/64284
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0270-6474
1529-2401
10.1523/JNEUROSCI.4372-06.2007
17360899
https://www.jneurosci.org/content/27/11/2781
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132568241569792

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