Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ibror.2017.08.002 http://hdl.handle.net/11449/209918 |
Resumo: | Retrospective studies in human populations indicate that protein deprivation during pregnancy and early life (early protein malnutrition, EPM) is associated with cognitive impairments, learning disabilities and may represent a risk factor for the late onset of some psychiatric disorders, fundamentally schizophrenia, a condition where the prefrontal cortex plays an important role. The purpose of this study was to analyze whether EPM affects structural aspects of the rat medial prefrontal cortex (mPFC), such as cortical volume, neuronal density and neuronal soma size, which seem altered in patients with schizophrenia. For this, a rat model of EPM (5% casein from conception to postnatal day 60) was adopted and the rat mPFC volume, total number of neurons and average neuronal volume were evaluated on postnatal day 60 (post-pubertal animals) by histo- and immunohistochemical techniques using unbiased stereological analysis. EPM did not alter the number of NeuN+ neurons in the rat mPFC. However, a very significant decrease in mPFC volume and average neuronal size was observed in malnourished rats. Although the present study does not establish causal relationships between malnutrition and schizophrenia, our results may indicate a similar structural phenomenon in these two situations. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal ratsMalnutritionPrefrontal cortexNeuronal sizeNeuronal densityNeuNStereologySchizophreniaRetrospective studies in human populations indicate that protein deprivation during pregnancy and early life (early protein malnutrition, EPM) is associated with cognitive impairments, learning disabilities and may represent a risk factor for the late onset of some psychiatric disorders, fundamentally schizophrenia, a condition where the prefrontal cortex plays an important role. The purpose of this study was to analyze whether EPM affects structural aspects of the rat medial prefrontal cortex (mPFC), such as cortical volume, neuronal density and neuronal soma size, which seem altered in patients with schizophrenia. For this, a rat model of EPM (5% casein from conception to postnatal day 60) was adopted and the rat mPFC volume, total number of neurons and average neuronal volume were evaluated on postnatal day 60 (post-pubertal animals) by histo- and immunohistochemical techniques using unbiased stereological analysis. EPM did not alter the number of NeuN+ neurons in the rat mPFC. However, a very significant decrease in mPFC volume and average neuronal size was observed in malnourished rats. Although the present study does not establish causal relationships between malnutrition and schizophrenia, our results may indicate a similar structural phenomenon in these two situations. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sao Paulo State Univ, Dept Basic Sci, Aracatuba, SP, BrazilSao Paulo State Univ, Dept Speech Language & Hearing Therapy, Marilia, SP, BrazilUniv Marilia, Sch Med, Dept Anat, Marilia, SP, BrazilUniv Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, SP, BrazilSao Paulo State Univ, Dept Basic Sci, Aracatuba, SP, BrazilSao Paulo State Univ, Dept Speech Language & Hearing Therapy, Marilia, SP, BrazilFAPESP: 2011/215093FAPESP: 2012/11307-7FAPESP: 2012/13433-0FAPESP: 2012/03067-6Elsevier B.V.Universidade Estadual Paulista (Unesp)Univ MariliaUniversidade de São Paulo (USP)Cruz-Rizzolo, Roelf J. [UNESP]Limieri, Lais Leal [UNESP]Paiva, Isabela Rogerio de [UNESP]Barbosa Ribeiro, Jessica O. [UNESP]Pimenta, Tais Fernandes [UNESP]Pinato, Luciana [UNESP]Ervolino, Edilson [UNESP]Casatti, Claudio Aparecido [UNESP]Guissoni Campos, Leila M.Liberti, Edson Aparecido2021-06-25T12:33:39Z2021-06-25T12:33:39Z2017-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article65-71http://dx.doi.org/10.1016/j.ibror.2017.08.002Ibro Reports. Amsterdam: Elsevier, v. 3, p. 65-71, 2017.2451-8301http://hdl.handle.net/11449/20991810.1016/j.ibror.2017.08.002WOS:00060862110000784874626269318770000-0001-5650-7343Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengIbro Reportsinfo:eu-repo/semantics/openAccess2021-12-14T14:02:05Zoai:repositorio.unesp.br:11449/209918Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-12-14T14:02:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats |
title |
Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats |
spellingShingle |
Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats Cruz-Rizzolo, Roelf J. [UNESP] Malnutrition Prefrontal cortex Neuronal size Neuronal density NeuN Stereology Schizophrenia |
title_short |
Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats |
title_full |
Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats |
title_fullStr |
Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats |
title_full_unstemmed |
Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats |
title_sort |
Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats |
author |
Cruz-Rizzolo, Roelf J. [UNESP] |
author_facet |
Cruz-Rizzolo, Roelf J. [UNESP] Limieri, Lais Leal [UNESP] Paiva, Isabela Rogerio de [UNESP] Barbosa Ribeiro, Jessica O. [UNESP] Pimenta, Tais Fernandes [UNESP] Pinato, Luciana [UNESP] Ervolino, Edilson [UNESP] Casatti, Claudio Aparecido [UNESP] Guissoni Campos, Leila M. Liberti, Edson Aparecido |
author_role |
author |
author2 |
Limieri, Lais Leal [UNESP] Paiva, Isabela Rogerio de [UNESP] Barbosa Ribeiro, Jessica O. [UNESP] Pimenta, Tais Fernandes [UNESP] Pinato, Luciana [UNESP] Ervolino, Edilson [UNESP] Casatti, Claudio Aparecido [UNESP] Guissoni Campos, Leila M. Liberti, Edson Aparecido |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Marilia Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Cruz-Rizzolo, Roelf J. [UNESP] Limieri, Lais Leal [UNESP] Paiva, Isabela Rogerio de [UNESP] Barbosa Ribeiro, Jessica O. [UNESP] Pimenta, Tais Fernandes [UNESP] Pinato, Luciana [UNESP] Ervolino, Edilson [UNESP] Casatti, Claudio Aparecido [UNESP] Guissoni Campos, Leila M. Liberti, Edson Aparecido |
dc.subject.por.fl_str_mv |
Malnutrition Prefrontal cortex Neuronal size Neuronal density NeuN Stereology Schizophrenia |
topic |
Malnutrition Prefrontal cortex Neuronal size Neuronal density NeuN Stereology Schizophrenia |
description |
Retrospective studies in human populations indicate that protein deprivation during pregnancy and early life (early protein malnutrition, EPM) is associated with cognitive impairments, learning disabilities and may represent a risk factor for the late onset of some psychiatric disorders, fundamentally schizophrenia, a condition where the prefrontal cortex plays an important role. The purpose of this study was to analyze whether EPM affects structural aspects of the rat medial prefrontal cortex (mPFC), such as cortical volume, neuronal density and neuronal soma size, which seem altered in patients with schizophrenia. For this, a rat model of EPM (5% casein from conception to postnatal day 60) was adopted and the rat mPFC volume, total number of neurons and average neuronal volume were evaluated on postnatal day 60 (post-pubertal animals) by histo- and immunohistochemical techniques using unbiased stereological analysis. EPM did not alter the number of NeuN+ neurons in the rat mPFC. However, a very significant decrease in mPFC volume and average neuronal size was observed in malnourished rats. Although the present study does not establish causal relationships between malnutrition and schizophrenia, our results may indicate a similar structural phenomenon in these two situations. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 2021-06-25T12:33:39Z 2021-06-25T12:33:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ibror.2017.08.002 Ibro Reports. Amsterdam: Elsevier, v. 3, p. 65-71, 2017. 2451-8301 http://hdl.handle.net/11449/209918 10.1016/j.ibror.2017.08.002 WOS:000608621100007 8487462626931877 0000-0001-5650-7343 |
url |
http://dx.doi.org/10.1016/j.ibror.2017.08.002 http://hdl.handle.net/11449/209918 |
identifier_str_mv |
Ibro Reports. Amsterdam: Elsevier, v. 3, p. 65-71, 2017. 2451-8301 10.1016/j.ibror.2017.08.002 WOS:000608621100007 8487462626931877 0000-0001-5650-7343 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ibro Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
65-71 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803046000966762496 |