Chitosan nanoparticles: a versatile platform for biomedical applications
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/18391 |
Resumo: | Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attention. This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering. |
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Chitosan nanoparticles: a versatile platform for biomedical applicationsDrug deliveryNanocarrierTarget therapyChemotherapyGene therapyTssue engineeringChitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attention. This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering.POCI-01-0145-FEDER-032610MDPISapientiaBashir, Showkeen MuzamilAhmed Rather, GulzarPatrício, AnaHaq, ZulfiqarSheikh, Amir AminShah, Mohd Zahoor ul HaqSingh, HemantKhan, Azmat AlamImtiyaz, SofiAhmad, Sheikh BilalNabi, ShowketRakhshan, RabiaHassan, SaqibFonte, Pedro2022-10-14T10:02:28Z2022-09-202022-10-13T12:59:40Z2022-09-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/18391engMaterials 15 (19): 6521 (2022)10.3390/ma151965211996-1944info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-13T02:07:59Zoai:sapientia.ualg.pt:10400.1/18391Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:08:10.023872Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chitosan nanoparticles: a versatile platform for biomedical applications |
title |
Chitosan nanoparticles: a versatile platform for biomedical applications |
spellingShingle |
Chitosan nanoparticles: a versatile platform for biomedical applications Bashir, Showkeen Muzamil Drug delivery Nanocarrier Target therapy Chemotherapy Gene therapy Tssue engineering |
title_short |
Chitosan nanoparticles: a versatile platform for biomedical applications |
title_full |
Chitosan nanoparticles: a versatile platform for biomedical applications |
title_fullStr |
Chitosan nanoparticles: a versatile platform for biomedical applications |
title_full_unstemmed |
Chitosan nanoparticles: a versatile platform for biomedical applications |
title_sort |
Chitosan nanoparticles: a versatile platform for biomedical applications |
author |
Bashir, Showkeen Muzamil |
author_facet |
Bashir, Showkeen Muzamil Ahmed Rather, Gulzar Patrício, Ana Haq, Zulfiqar Sheikh, Amir Amin Shah, Mohd Zahoor ul Haq Singh, Hemant Khan, Azmat Alam Imtiyaz, Sofi Ahmad, Sheikh Bilal Nabi, Showket Rakhshan, Rabia Hassan, Saqib Fonte, Pedro |
author_role |
author |
author2 |
Ahmed Rather, Gulzar Patrício, Ana Haq, Zulfiqar Sheikh, Amir Amin Shah, Mohd Zahoor ul Haq Singh, Hemant Khan, Azmat Alam Imtiyaz, Sofi Ahmad, Sheikh Bilal Nabi, Showket Rakhshan, Rabia Hassan, Saqib Fonte, Pedro |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Bashir, Showkeen Muzamil Ahmed Rather, Gulzar Patrício, Ana Haq, Zulfiqar Sheikh, Amir Amin Shah, Mohd Zahoor ul Haq Singh, Hemant Khan, Azmat Alam Imtiyaz, Sofi Ahmad, Sheikh Bilal Nabi, Showket Rakhshan, Rabia Hassan, Saqib Fonte, Pedro |
dc.subject.por.fl_str_mv |
Drug delivery Nanocarrier Target therapy Chemotherapy Gene therapy Tssue engineering |
topic |
Drug delivery Nanocarrier Target therapy Chemotherapy Gene therapy Tssue engineering |
description |
Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attention. This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-14T10:02:28Z 2022-09-20 2022-10-13T12:59:40Z 2022-09-20T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/18391 |
url |
http://hdl.handle.net/10400.1/18391 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials 15 (19): 6521 (2022) 10.3390/ma15196521 1996-1944 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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MDPI |
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MDPI |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133327339290624 |