Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.25756/rpf.v8i2.115 |
Resumo: | Introduction: The lack of knowledge regarding the incidence of adverse drug reactions in the hospital setting and their impact on morbidity and mortality is, nowadays, a major health problem in Angola. In the last years, notifications of adverse drug reactions have been practically null, namely at a hospital level. It is of great importance to characterize the incidence of adverse drug reactions occurring in a hospital setting, in order to implement measures towards improving the quality of healthcare services. Material and Methods: We conducted a descriptive, prospective observational study to characterize the incidence of adverse drug reactions (ADRs) in patients admitted to the Central Hospital “Josina Machel” in Luanda during the year 2014. An intensive monitoring through active search for adverse reactions possibly related with the drugs prescribed to patients was performed.Results: Of a total of 2041 hospitalized patients, 175 had adverse drug reactions. The incidence rate was 4.74% in the medicine service (n = 1077) and 12.86% in the therapy service (n = 964). A total of 209 adverse drug reactions were identified, averaging 1,2 adverse drug reactions per patient. The highest incidence rate of adverse drug reactions was recorded in patients aged between 18 and 35 years old, with 79 patients (45.14%). With regard to therapeutic class, it was found that antimicrobials were the drugs most commonly associated with adverse reactions, with 71 notifications (40.57%), followed by analgesics, antipyretics and anti-inflammatory steroids with 20,00%. Quinine and artesunate were the antimicrobials most frequently implicated in causing an adverse drug reaction, with 25 (14.29%) and 15 (8.57%) notifications respectively. In the group of anti-inflammatory drugs, diclofenac stood out with 13 notifications (7.43%). The most common clinical manifestations were skin rash, which corresponded to 23,44% of the total number of adverse drug reactions, followed by bleeding, which accounted for 8.6% of the number of adverse reactions registered (n = 18). Within the group of antimicrobials, antimalarials and cephalosporins were the drugs most commonly associated with skin lesions, with 27 notifications (55.10%). Most of adverse reactions were moderate in severity (66.86%) and were classified as probably drug-related (80.57%).Discussion and Conclusion: A high frequency of adverse drug reactions was found in hospitalized patients, particularly in the therapy service. It was evident the subnotification of adverse reactions by health professionals and the need for a system of notification of adverse reactions that combines passive and active surveillance for the prevention and detection of adverse drug reactions. |
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Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014Incidência de Reações Adversas a Medicamentos nos Serviços de Medicina e Terapia do Hospital Central Josina Machel, em 2014Introduction: The lack of knowledge regarding the incidence of adverse drug reactions in the hospital setting and their impact on morbidity and mortality is, nowadays, a major health problem in Angola. In the last years, notifications of adverse drug reactions have been practically null, namely at a hospital level. It is of great importance to characterize the incidence of adverse drug reactions occurring in a hospital setting, in order to implement measures towards improving the quality of healthcare services. Material and Methods: We conducted a descriptive, prospective observational study to characterize the incidence of adverse drug reactions (ADRs) in patients admitted to the Central Hospital “Josina Machel” in Luanda during the year 2014. An intensive monitoring through active search for adverse reactions possibly related with the drugs prescribed to patients was performed.Results: Of a total of 2041 hospitalized patients, 175 had adverse drug reactions. The incidence rate was 4.74% in the medicine service (n = 1077) and 12.86% in the therapy service (n = 964). A total of 209 adverse drug reactions were identified, averaging 1,2 adverse drug reactions per patient. The highest incidence rate of adverse drug reactions was recorded in patients aged between 18 and 35 years old, with 79 patients (45.14%). With regard to therapeutic class, it was found that antimicrobials were the drugs most commonly associated with adverse reactions, with 71 notifications (40.57%), followed by analgesics, antipyretics and anti-inflammatory steroids with 20,00%. Quinine and artesunate were the antimicrobials most frequently implicated in causing an adverse drug reaction, with 25 (14.29%) and 15 (8.57%) notifications respectively. In the group of anti-inflammatory drugs, diclofenac stood out with 13 notifications (7.43%). The most common clinical manifestations were skin rash, which corresponded to 23,44% of the total number of adverse drug reactions, followed by bleeding, which accounted for 8.6% of the number of adverse reactions registered (n = 18). Within the group of antimicrobials, antimalarials and cephalosporins were the drugs most commonly associated with skin lesions, with 27 notifications (55.10%). Most of adverse reactions were moderate in severity (66.86%) and were classified as probably drug-related (80.57%).Discussion and Conclusion: A high frequency of adverse drug reactions was found in hospitalized patients, particularly in the therapy service. It was evident the subnotification of adverse reactions by health professionals and the need for a system of notification of adverse reactions that combines passive and active surveillance for the prevention and detection of adverse drug reactions.Introdução: O desconhecimento da incidência das reações adversas a medicamentos no meio hospitalar e a sua influência na morbilidade e mortalidade constituem hoje um problema de saúde em Angola. Nos últimos anos são praticamente nulas as notificações de reações adversas a medicamentos, em especial ao nível dos cuidados hospitalares. Reveste-se de extrema importância caracterizar a incidência das reações adversas a medicamentos que ocorrem em contexto hospitalar, de modo a implementar medidas cujo objetivo último seja a melhoria dos cuidados de saúde prestados.Material e Métodos: Realizou-se um estudo observacional descritivo e prospetivo, para caracterizar a incidência das reações adversas a medicamentos que se apresentaram em pacientes internados no Hospital Central Josina Machel, em Luanda, durante o ano 2014. Foi feita uma monitorização intensiva através da pesquisa ativa de efeitos adversos potencialmente associados aos medicamentos prescritos.Resultados: Do total de 2041 pacientes internados, 175 foram afetados por reações adversas a medicamentos. Na área de medicina (n = 1077), a taxa de incidência foi de 4,74% e, na área de terapia (n = 964), foi de 12,86%. Detetou-se um total de 209 reações adversas a medicamentos, o que corresponde a uma média de 1,2 reações adversas a medicamentos por paciente. A maior incidência de reações adversas a medicamentos registou-se nos doentes com idade entre os 18 e os 35 anos, em 79 pacientes (45,14%). Relativamente à classe terapêutica verificou-se que os antimicrobianos foram os medicamentos mais frequentemente associados à ocorrência de reações adversas a medicamentos, com 71 notificações (40,57%), seguido dos analgésicos, antipiréticos e anti-inflamatórios não-esteroides, com 20%. Dentro dos antimicrobianos, o quinino e o artesumato foram os que originaram maior número de notificações, 25 (14,29%) e 15 (8,57%) respetivamente. No grupo dos anti-inflamatórios não-esteroides destaca-se o diclofenac, com 13 notificações (7,43%). As manifestações clínicas mais frequentes foram o rash cutâneo, que correspondeu a 23,44% das reações adversas registadas, seguido do sangramento, observado em 8,61% dos casos de reações adversas (n=18). Dentro do grupo dos antimicrobianos foram os antimaláricos e as cefalosporinas que corresponderam com maior frequência às lesões cutâneas, em 27 notificações (55,10%). No que respeita à severidade das reações adversas tiveram preponderância as moderadas, com 66,86% (n = 117), seguidas das graves com 22,29%. A maioria das reações adversas foi classificada como provável (80,57%).Discussão e Conclusão: Evidenciou-se uma elevada frequência de ocorrência de reações adversas a medicamentos em pacientes hospitalizados, em especial nos serviços de terapia. Os antimicrobianos, os analgésicos, os antipiréticos e os anti-inflamatórios contribuíram para a maior frequência de eventos adversos. Importa ainda salientar a subnotificação de reações adversas a medicamentos pelos profissionais de saúde e a necessidade de contar com um sistema de notificação de eventos adversos a medicamentos que combine técnicas de vigilância passiva e ativa para a prevenção e deteção das reações adversas a medicamentos.Formifarma2016-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.25756/rpf.v8i2.115https://doi.org/10.25756/rpf.v8i2.115Revista Portuguesa de Farmacoterapia / Portuguese Journal of Pharmacotherapy; Vol 8 No 2 (2016): Abril; 21-27Revista Portuguesa de Farmacoterapia; v. 8 n. 2 (2016): Abril; 21-272183-73411647-354Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttp://revista.farmacoterapia.pt/index.php/rpf/article/view/115http://revista.farmacoterapia.pt/index.php/rpf/article/view/115/94Direitos de Autor (c) 2017 Revista Portuguesa de Farmacoterapiahttp://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessMateus Sebastião, João FernandesFernández Héctor, LaraCalzadilla Moreira, VladimirGomez Macineira, Ignacio MiguelAlmeida Alfonso, Mário Héctor2023-09-01T04:33:34Zoai:ojs.farmacoterapia.pt:article/115Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:11:34.535441Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014 Incidência de Reações Adversas a Medicamentos nos Serviços de Medicina e Terapia do Hospital Central Josina Machel, em 2014 |
title |
Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014 |
spellingShingle |
Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014 Mateus Sebastião, João Fernandes |
title_short |
Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014 |
title_full |
Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014 |
title_fullStr |
Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014 |
title_full_unstemmed |
Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014 |
title_sort |
Incidence of Adverse Reactions to Medicinal Products in Josina Machel Central Hospital during the Year of 2014 |
author |
Mateus Sebastião, João Fernandes |
author_facet |
Mateus Sebastião, João Fernandes Fernández Héctor, Lara Calzadilla Moreira, Vladimir Gomez Macineira, Ignacio Miguel Almeida Alfonso, Mário Héctor |
author_role |
author |
author2 |
Fernández Héctor, Lara Calzadilla Moreira, Vladimir Gomez Macineira, Ignacio Miguel Almeida Alfonso, Mário Héctor |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Mateus Sebastião, João Fernandes Fernández Héctor, Lara Calzadilla Moreira, Vladimir Gomez Macineira, Ignacio Miguel Almeida Alfonso, Mário Héctor |
description |
Introduction: The lack of knowledge regarding the incidence of adverse drug reactions in the hospital setting and their impact on morbidity and mortality is, nowadays, a major health problem in Angola. In the last years, notifications of adverse drug reactions have been practically null, namely at a hospital level. It is of great importance to characterize the incidence of adverse drug reactions occurring in a hospital setting, in order to implement measures towards improving the quality of healthcare services. Material and Methods: We conducted a descriptive, prospective observational study to characterize the incidence of adverse drug reactions (ADRs) in patients admitted to the Central Hospital “Josina Machel” in Luanda during the year 2014. An intensive monitoring through active search for adverse reactions possibly related with the drugs prescribed to patients was performed.Results: Of a total of 2041 hospitalized patients, 175 had adverse drug reactions. The incidence rate was 4.74% in the medicine service (n = 1077) and 12.86% in the therapy service (n = 964). A total of 209 adverse drug reactions were identified, averaging 1,2 adverse drug reactions per patient. The highest incidence rate of adverse drug reactions was recorded in patients aged between 18 and 35 years old, with 79 patients (45.14%). With regard to therapeutic class, it was found that antimicrobials were the drugs most commonly associated with adverse reactions, with 71 notifications (40.57%), followed by analgesics, antipyretics and anti-inflammatory steroids with 20,00%. Quinine and artesunate were the antimicrobials most frequently implicated in causing an adverse drug reaction, with 25 (14.29%) and 15 (8.57%) notifications respectively. In the group of anti-inflammatory drugs, diclofenac stood out with 13 notifications (7.43%). The most common clinical manifestations were skin rash, which corresponded to 23,44% of the total number of adverse drug reactions, followed by bleeding, which accounted for 8.6% of the number of adverse reactions registered (n = 18). Within the group of antimicrobials, antimalarials and cephalosporins were the drugs most commonly associated with skin lesions, with 27 notifications (55.10%). Most of adverse reactions were moderate in severity (66.86%) and were classified as probably drug-related (80.57%).Discussion and Conclusion: A high frequency of adverse drug reactions was found in hospitalized patients, particularly in the therapy service. It was evident the subnotification of adverse reactions by health professionals and the need for a system of notification of adverse reactions that combines passive and active surveillance for the prevention and detection of adverse drug reactions. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.25756/rpf.v8i2.115 https://doi.org/10.25756/rpf.v8i2.115 |
url |
https://doi.org/10.25756/rpf.v8i2.115 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
http://revista.farmacoterapia.pt/index.php/rpf/article/view/115 http://revista.farmacoterapia.pt/index.php/rpf/article/view/115/94 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2017 Revista Portuguesa de Farmacoterapia http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2017 Revista Portuguesa de Farmacoterapia http://creativecommons.org/licenses/by-nc-nd/4.0 |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Formifarma |
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Formifarma |
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Revista Portuguesa de Farmacoterapia / Portuguese Journal of Pharmacotherapy; Vol 8 No 2 (2016): Abril; 21-27 Revista Portuguesa de Farmacoterapia; v. 8 n. 2 (2016): Abril; 21-27 2183-7341 1647-354X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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