G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/21245 |
Resumo: | Background: São Tomé and Príncipe (STP) is a least developed country (LDC) on Sub-Saharan Africa, in which was detected a high prevalence of sensorineural Hearing Loss (SNHL). HL is a common condition with both genetic and environmental causes, and it greatly impacts on global health. STP population has leading with additional health problems over the years, such as anaemia and malaria infection. The present study aims to identify the correlation between the most prevalent G6PD variants and the high prevalence of HL in STP population. Methods: A sample of 316 individuals collected during Humanitarian Missions in STP, was retrospectively studied in a case-control approach to evaluate the role of G6PD gene variants in individual susceptibility to HL and it correlation with other potential risk factors. Results: The results obtained showed an increased risk for those cases that have reported malaria infection (OR 1.867, CI 95% [1.107-3.48]) in global population. The same effect of increased risk was found after stratification for male gender (OR 3.721 CI 95% [1.631-8.489]). Conclusions: Our results did not allow us to correlate any specific variant of G6PD gene with HL. However, emphasize the hypothetical correlation between malaria infection and the increased risk for HL. |
id |
RCAP_6e1a0c7e76df1475e3f043bfbb3718b2 |
---|---|
oai_identifier_str |
oai:comum.rcaap.pt:10400.26/21245 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control studyBackground: São Tomé and Príncipe (STP) is a least developed country (LDC) on Sub-Saharan Africa, in which was detected a high prevalence of sensorineural Hearing Loss (SNHL). HL is a common condition with both genetic and environmental causes, and it greatly impacts on global health. STP population has leading with additional health problems over the years, such as anaemia and malaria infection. The present study aims to identify the correlation between the most prevalent G6PD variants and the high prevalence of HL in STP population. Methods: A sample of 316 individuals collected during Humanitarian Missions in STP, was retrospectively studied in a case-control approach to evaluate the role of G6PD gene variants in individual susceptibility to HL and it correlation with other potential risk factors. Results: The results obtained showed an increased risk for those cases that have reported malaria infection (OR 1.867, CI 95% [1.107-3.48]) in global population. The same effect of increased risk was found after stratification for male gender (OR 3.721 CI 95% [1.631-8.489]). Conclusions: Our results did not allow us to correlate any specific variant of G6PD gene with HL. However, emphasize the hypothetical correlation between malaria infection and the increased risk for HL.Repositório ComumCaroça, CristinaCampelo, PaulaCaria, HelenaPaço, JoãoSilva, Susana2018-02-15T15:25:33Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/21245engCaroça, C., Campelo, P., Caria, H., Paço, J. & Silva, S. N.(2017). G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: A case-control study. International Journal of Medical Research &Health Sciences, 6(6), p.p. 8-16.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T09:53:23Zoai:comum.rcaap.pt:10400.26/21245Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:09:18.765795Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study |
title |
G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study |
spellingShingle |
G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study Caroça, Cristina |
title_short |
G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study |
title_full |
G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study |
title_fullStr |
G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study |
title_full_unstemmed |
G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study |
title_sort |
G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study |
author |
Caroça, Cristina |
author_facet |
Caroça, Cristina Campelo, Paula Caria, Helena Paço, João Silva, Susana |
author_role |
author |
author2 |
Campelo, Paula Caria, Helena Paço, João Silva, Susana |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Caroça, Cristina Campelo, Paula Caria, Helena Paço, João Silva, Susana |
description |
Background: São Tomé and Príncipe (STP) is a least developed country (LDC) on Sub-Saharan Africa, in which was detected a high prevalence of sensorineural Hearing Loss (SNHL). HL is a common condition with both genetic and environmental causes, and it greatly impacts on global health. STP population has leading with additional health problems over the years, such as anaemia and malaria infection. The present study aims to identify the correlation between the most prevalent G6PD variants and the high prevalence of HL in STP population. Methods: A sample of 316 individuals collected during Humanitarian Missions in STP, was retrospectively studied in a case-control approach to evaluate the role of G6PD gene variants in individual susceptibility to HL and it correlation with other potential risk factors. Results: The results obtained showed an increased risk for those cases that have reported malaria infection (OR 1.867, CI 95% [1.107-3.48]) in global population. The same effect of increased risk was found after stratification for male gender (OR 3.721 CI 95% [1.631-8.489]). Conclusions: Our results did not allow us to correlate any specific variant of G6PD gene with HL. However, emphasize the hypothetical correlation between malaria infection and the increased risk for HL. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2018-02-15T15:25:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/21245 |
url |
http://hdl.handle.net/10400.26/21245 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Caroça, C., Campelo, P., Caria, H., Paço, J. & Silva, S. N.(2017). G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: A case-control study. International Journal of Medical Research &Health Sciences, 6(6), p.p. 8-16. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799135354311147520 |