Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations

Detalhes bibliográficos
Autor(a) principal: Rosas, A.
Data de Publicação: 2005
Outros Autores: Gordo, I., Campos, P.R.A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/92
Resumo: We investigate the dynamics of loss of favorable mutations in an asexual haploid population. In the current work, we consider homogeneous as well as spatially structured population models. We focus our analysis on statistical measurements of the probability distribution of the maximum population size N(sb) achieved by those mutations that have not reached fixation. Our results show a crossover behavior which demonstrates the occurrence of two evolutionary regimes. In the first regime, which takes place for small N(sb) , the probability distribution is described by a power law with characteristic exponent theta(d) =1.8 +/- 0.01. This power law is not influenced by the rate of beneficial mutations. The second regime, which occurs for intermediate to large values of N(sb), has a characteristic exponent theta(c) which increases as the rate of beneficial mutations grows. These results establish where genetic drift and clonal interference become the main underlying mechanism in the extinction of advantageous mutations.
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spelling Scaling, genetic drift and clonal interference in the extinction pattern of asexual populationsExtinction, PsychologicalGenetic DriftGenetics, PopulationReproduction, AsexualWe investigate the dynamics of loss of favorable mutations in an asexual haploid population. In the current work, we consider homogeneous as well as spatially structured population models. We focus our analysis on statistical measurements of the probability distribution of the maximum population size N(sb) achieved by those mutations that have not reached fixation. Our results show a crossover behavior which demonstrates the occurrence of two evolutionary regimes. In the first regime, which takes place for small N(sb) , the probability distribution is described by a power law with characteristic exponent theta(d) =1.8 +/- 0.01. This power law is not influenced by the rate of beneficial mutations. The second regime, which occurs for intermediate to large values of N(sb), has a characteristic exponent theta(c) which increases as the rate of beneficial mutations grows. These results establish where genetic drift and clonal interference become the main underlying mechanism in the extinction of advantageous mutations.American Physical SocietyARCARosas, A.Gordo, I.Campos, P.R.A.2010-03-25T16:15:45Z2005-07-052005-07-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/92engRosas, A., I.Gordo and P.R.A. Campos (2005) Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations. Phys.Rev. E 72, 0129011744-956110.1103/PhysRevE.72.012901info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:38Zoai:arca.igc.gulbenkian.pt:10400.7/92Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:34.540225Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations
title Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations
spellingShingle Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations
Rosas, A.
Extinction, Psychological
Genetic Drift
Genetics, Population
Reproduction, Asexual
title_short Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations
title_full Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations
title_fullStr Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations
title_full_unstemmed Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations
title_sort Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations
author Rosas, A.
author_facet Rosas, A.
Gordo, I.
Campos, P.R.A.
author_role author
author2 Gordo, I.
Campos, P.R.A.
author2_role author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Rosas, A.
Gordo, I.
Campos, P.R.A.
dc.subject.por.fl_str_mv Extinction, Psychological
Genetic Drift
Genetics, Population
Reproduction, Asexual
topic Extinction, Psychological
Genetic Drift
Genetics, Population
Reproduction, Asexual
description We investigate the dynamics of loss of favorable mutations in an asexual haploid population. In the current work, we consider homogeneous as well as spatially structured population models. We focus our analysis on statistical measurements of the probability distribution of the maximum population size N(sb) achieved by those mutations that have not reached fixation. Our results show a crossover behavior which demonstrates the occurrence of two evolutionary regimes. In the first regime, which takes place for small N(sb) , the probability distribution is described by a power law with characteristic exponent theta(d) =1.8 +/- 0.01. This power law is not influenced by the rate of beneficial mutations. The second regime, which occurs for intermediate to large values of N(sb), has a characteristic exponent theta(c) which increases as the rate of beneficial mutations grows. These results establish where genetic drift and clonal interference become the main underlying mechanism in the extinction of advantageous mutations.
publishDate 2005
dc.date.none.fl_str_mv 2005-07-05
2005-07-05T00:00:00Z
2010-03-25T16:15:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/92
url http://hdl.handle.net/10400.7/92
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rosas, A., I.Gordo and P.R.A. Campos (2005) Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations. Phys.Rev. E 72, 012901
1744-9561
10.1103/PhysRevE.72.012901
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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