Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/92 |
Resumo: | We investigate the dynamics of loss of favorable mutations in an asexual haploid population. In the current work, we consider homogeneous as well as spatially structured population models. We focus our analysis on statistical measurements of the probability distribution of the maximum population size N(sb) achieved by those mutations that have not reached fixation. Our results show a crossover behavior which demonstrates the occurrence of two evolutionary regimes. In the first regime, which takes place for small N(sb) , the probability distribution is described by a power law with characteristic exponent theta(d) =1.8 +/- 0.01. This power law is not influenced by the rate of beneficial mutations. The second regime, which occurs for intermediate to large values of N(sb), has a characteristic exponent theta(c) which increases as the rate of beneficial mutations grows. These results establish where genetic drift and clonal interference become the main underlying mechanism in the extinction of advantageous mutations. |
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Scaling, genetic drift and clonal interference in the extinction pattern of asexual populationsExtinction, PsychologicalGenetic DriftGenetics, PopulationReproduction, AsexualWe investigate the dynamics of loss of favorable mutations in an asexual haploid population. In the current work, we consider homogeneous as well as spatially structured population models. We focus our analysis on statistical measurements of the probability distribution of the maximum population size N(sb) achieved by those mutations that have not reached fixation. Our results show a crossover behavior which demonstrates the occurrence of two evolutionary regimes. In the first regime, which takes place for small N(sb) , the probability distribution is described by a power law with characteristic exponent theta(d) =1.8 +/- 0.01. This power law is not influenced by the rate of beneficial mutations. The second regime, which occurs for intermediate to large values of N(sb), has a characteristic exponent theta(c) which increases as the rate of beneficial mutations grows. These results establish where genetic drift and clonal interference become the main underlying mechanism in the extinction of advantageous mutations.American Physical SocietyARCARosas, A.Gordo, I.Campos, P.R.A.2010-03-25T16:15:45Z2005-07-052005-07-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/92engRosas, A., I.Gordo and P.R.A. Campos (2005) Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations. Phys.Rev. E 72, 0129011744-956110.1103/PhysRevE.72.012901info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:38Zoai:arca.igc.gulbenkian.pt:10400.7/92Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:34.540225Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations |
title |
Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations |
spellingShingle |
Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations Rosas, A. Extinction, Psychological Genetic Drift Genetics, Population Reproduction, Asexual |
title_short |
Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations |
title_full |
Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations |
title_fullStr |
Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations |
title_full_unstemmed |
Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations |
title_sort |
Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations |
author |
Rosas, A. |
author_facet |
Rosas, A. Gordo, I. Campos, P.R.A. |
author_role |
author |
author2 |
Gordo, I. Campos, P.R.A. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Rosas, A. Gordo, I. Campos, P.R.A. |
dc.subject.por.fl_str_mv |
Extinction, Psychological Genetic Drift Genetics, Population Reproduction, Asexual |
topic |
Extinction, Psychological Genetic Drift Genetics, Population Reproduction, Asexual |
description |
We investigate the dynamics of loss of favorable mutations in an asexual haploid population. In the current work, we consider homogeneous as well as spatially structured population models. We focus our analysis on statistical measurements of the probability distribution of the maximum population size N(sb) achieved by those mutations that have not reached fixation. Our results show a crossover behavior which demonstrates the occurrence of two evolutionary regimes. In the first regime, which takes place for small N(sb) , the probability distribution is described by a power law with characteristic exponent theta(d) =1.8 +/- 0.01. This power law is not influenced by the rate of beneficial mutations. The second regime, which occurs for intermediate to large values of N(sb), has a characteristic exponent theta(c) which increases as the rate of beneficial mutations grows. These results establish where genetic drift and clonal interference become the main underlying mechanism in the extinction of advantageous mutations. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-07-05 2005-07-05T00:00:00Z 2010-03-25T16:15:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/92 |
url |
http://hdl.handle.net/10400.7/92 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rosas, A., I.Gordo and P.R.A. Campos (2005) Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations. Phys.Rev. E 72, 012901 1744-9561 10.1103/PhysRevE.72.012901 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Physical Society |
publisher.none.fl_str_mv |
American Physical Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130571428855808 |