Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/123695 |
Resumo: | UID/FIS/04559/2020 |
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7160 |
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Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroidsChemistry(all)Chemical Engineering(all)SDG 3 - Good Health and Well-beingUID/FIS/04559/2020The use of nanomaterials to improve medical diagnostics and therapeutics has been rapidly increasing. Among these materials are gold nanoparticles, which can be functionalized to target specific cells, acting as nanovectors for drug delivery, enhanced contrast agents as well as other targeted therapies. Au nanoparticles are very useful as they selectively accumulate in tumour sites due to the enhanced permeability-retention effect. There is however little information about the spatial distribution of the nanoparticles within tumours, which might hinder efficient therapies. In this study, X-ray fluorescence was used to investigate the diffusion of gold nanoparticles in cancer cell spheroids mimicking true tumour growth. Functionalization of the nanoparticles has the effect of allowing better diffusion into and out of the spheroid, while those nanoparticles that are only partially covered rapidly formed aggregates. This clustering led to size exclusion during transport within the tumour, changing its distribution profile while greatly increasing the nanoparticle concentration.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitLIBPhys-UNLDF – Departamento de FísicaRUNPedrosa, PedroBaptista, Pedro V.Fernandes, Alexandra R.Guerra, Mauro2021-09-03T00:13:37Z2021-07-222021-07-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/123695eng2046-2069PURE: 33348391https://doi.org/10.1039/d1ra05446einfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:05:03Zoai:run.unl.pt:10362/123695Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:09.250919Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids |
title |
Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids |
spellingShingle |
Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids Pedrosa, Pedro Chemistry(all) Chemical Engineering(all) SDG 3 - Good Health and Well-being |
title_short |
Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids |
title_full |
Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids |
title_fullStr |
Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids |
title_full_unstemmed |
Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids |
title_sort |
Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids |
author |
Pedrosa, Pedro |
author_facet |
Pedrosa, Pedro Baptista, Pedro V. Fernandes, Alexandra R. Guerra, Mauro |
author_role |
author |
author2 |
Baptista, Pedro V. Fernandes, Alexandra R. Guerra, Mauro |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
DCV - Departamento de Ciências da Vida UCIBIO - Applied Molecular Biosciences Unit LIBPhys-UNL DF – Departamento de Física RUN |
dc.contributor.author.fl_str_mv |
Pedrosa, Pedro Baptista, Pedro V. Fernandes, Alexandra R. Guerra, Mauro |
dc.subject.por.fl_str_mv |
Chemistry(all) Chemical Engineering(all) SDG 3 - Good Health and Well-being |
topic |
Chemistry(all) Chemical Engineering(all) SDG 3 - Good Health and Well-being |
description |
UID/FIS/04559/2020 |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-03T00:13:37Z 2021-07-22 2021-07-22T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/123695 |
url |
http://hdl.handle.net/10362/123695 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2046-2069 PURE: 33348391 https://doi.org/10.1039/d1ra05446e |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138057396420608 |