Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis

Detalhes bibliográficos
Autor(a) principal: Costa, André
Data de Publicação: 2022
Outros Autores: Luís, Salomé, Noro, Jennifer Martins, Silva, Sónia Carina, Silva, C., Ribeiro, Artur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/80672
Resumo: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ijms232213999/s1.
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spelling Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosiskeratin-based particlesterbinafinetherapeutic textilesScience & TechnologyThe following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ijms232213999/s1.Onychomycosis is the most common nail fungal infection worldwide. There are several therapy options available for onychomycosis, such as oral antifungals, topicals, and physical treatments. Terbinafine is in the frontline for the treatment of onychomycosis; however, several adverse effects are associated to its oral administration. In this work, innovative keratin-based carriers encapsulating terbinafine were designed to overcome the drawbacks related to the use this drug. Therapeutic textiles functionalized with keratin-based particles (100% keratin; 80% keratin/20% keratin-PEG) encapsulating terbinafine were developed. The controlled release of terbinafine from the functionalized textiles was evaluated against different mimetic biologic solutions (PBS buffer—pH=7.4, micellar solution and acidic sweat solution—pH=4.3). The modification of keratin with polyethylene glycol (PEG) moieties favored the release of terbinafine at the end of 48 h for all the solution conditions. When the activity of functionalized textiles was tested against Trichophyton rubrum, a differentiated inhibition was observed. Textiles functionalized with 80% keratin/20% keratin-PEG encapsulating terbinafine showed a 2-fold inhibition halo compared with the textiles containing 100% keratin-encapsulating terbinafine. No activity was observed for the textiles functionalized with keratin-based particles without terbinafine. The systems herein developed revealed therapeutic potential towards nail fungal infections, taking advantage of keratin-based particles affinity to keratin structures and of the keratinase activity of T. rubrum.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit, and by LABBELS – Associate Laboratory in Biotechnology, Bioengineering and Microelectromechanical Systems, LA/P/0029/2020. AR thanks to Portuguese Foundation for Science and Technology (FCT) for is con tract under the CEEC-Individual—4th Edition with the reference 2021.02803.CEECIND.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoCosta, AndréLuís, SaloméNoro, Jennifer MartinsSilva, Sónia CarinaSilva, C.Ribeiro, Artur2022-11-132022-11-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/80672engCosta, A.F.; Luís, S.; Noro, J.; Silva, S.; Silva, C.; Ribeiro, A. Therapeutic Textiles Functionalized with Keratin-Based Particles Encapsulating Terbinafine for the Treatment of Onychomycosis. Int. J. Mol. Sci. 2022, 23, 13999. https://doi.org/10.3390/ijms2322139991424-67831661-65961422-006710.3390/ijms23221399936430474https://www.mdpi.com/1422-0067/23/22/13999info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:34:48Zoai:repositorium.sdum.uminho.pt:1822/80672Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:30:33.318623Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis
title Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis
spellingShingle Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis
Costa, André
keratin-based particles
terbinafine
therapeutic textiles
Science & Technology
title_short Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis
title_full Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis
title_fullStr Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis
title_full_unstemmed Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis
title_sort Therapeutic textiles functionalized with keratin-based particles encapsulating terbinafine for the treatment of onychomycosis
author Costa, André
author_facet Costa, André
Luís, Salomé
Noro, Jennifer Martins
Silva, Sónia Carina
Silva, C.
Ribeiro, Artur
author_role author
author2 Luís, Salomé
Noro, Jennifer Martins
Silva, Sónia Carina
Silva, C.
Ribeiro, Artur
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Costa, André
Luís, Salomé
Noro, Jennifer Martins
Silva, Sónia Carina
Silva, C.
Ribeiro, Artur
dc.subject.por.fl_str_mv keratin-based particles
terbinafine
therapeutic textiles
Science & Technology
topic keratin-based particles
terbinafine
therapeutic textiles
Science & Technology
description The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ijms232213999/s1.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-13
2022-11-13T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/80672
url https://hdl.handle.net/1822/80672
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Costa, A.F.; Luís, S.; Noro, J.; Silva, S.; Silva, C.; Ribeiro, A. Therapeutic Textiles Functionalized with Keratin-Based Particles Encapsulating Terbinafine for the Treatment of Onychomycosis. Int. J. Mol. Sci. 2022, 23, 13999. https://doi.org/10.3390/ijms232213999
1424-6783
1661-6596
1422-0067
10.3390/ijms232213999
36430474
https://www.mdpi.com/1422-0067/23/22/13999
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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