Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study

Detalhes bibliográficos
Autor(a) principal: Taipa, Ricardo Jorge Ferreira
Data de Publicação: 2018
Outros Autores: Ferreira, V., Brochado, P., Robinson, A, Reis, I., Marques, Fernanda, Mann, D. M., Melo-Pires, M., Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/57951
Resumo: The association between the pathological features of AD and dementia is stronger in younger old persons than in older old persons suggesting that additional factors are involved in the clinical expression of dementia in the oldest old. Cumulative data suggests that neuroinflammation plays a prominent role in Alzheimer's disease (AD) and different studies reported an age-associated dysregulation of the neuroimmune system. Consequently, we sought to characterize the pattern of microglial cell activation and astrogliosis in brain post mortem tissue of pathologically confirmed cases of early and late onset AD (EOAD and LOAD) and determine their relation to age.
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spelling Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem studyAgeingAlzheimer´s diseaseAstrocytesMicrogliaPathologyCiências Médicas::Medicina BásicaScience & TechnologyThe association between the pathological features of AD and dementia is stronger in younger old persons than in older old persons suggesting that additional factors are involved in the clinical expression of dementia in the oldest old. Cumulative data suggests that neuroinflammation plays a prominent role in Alzheimer's disease (AD) and different studies reported an age-associated dysregulation of the neuroimmune system. Consequently, we sought to characterize the pattern of microglial cell activation and astrogliosis in brain post mortem tissue of pathologically confirmed cases of early and late onset AD (EOAD and LOAD) and determine their relation to age.‘Bolsa para Investigação’ of Centro Hospitalar do Porto. The work at ICVS/3B's has been developed under the scope of the project NORTE‐01‐0145‐FEDER‐000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER), and funded by FEDER funds through the Competitiveness Factors Operational Programme (COMPETE), and the Foundation for Science and Technology (FCT), under the scope of the project POCI‐01‐0145‐FEDER‐007038. We acknowledge The Manchester Brain Bank, The Queen Square Brain Bank and the Oxford Brain Bank [supported by the Medical Research Council (MRC), the NIHR Oxford Biomedical Research Centre and the Brains for Dementia Research programme, jointly funded by Alzheimer′s Research UK and Alzheimer′s Society] for tissue samples supplyinfo:eu-repo/semantics/publishedVersionWileyUniversidade do MinhoTaipa, Ricardo Jorge FerreiraFerreira, V.Brochado, P.Robinson, AReis, I.Marques, FernandaMann, D. M.Melo-Pires, M.Sousa, Nuno20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57951engTaipa, R., Ferreira, V., Brochado, P., Robinson, A., Reis, I., Marques, F., ... & Sousa, N. (2018). Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study. Neuropathology and applied neurobiology, 44(3), 298-3130305-18461365-299010.1111/nan.1244529044639https://onlinelibrary.wiley.com/doi/full/10.1111/nan.12445info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:39:59Zoai:repositorium.sdum.uminho.pt:1822/57951Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:36:42.631262Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
title Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
spellingShingle Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
Taipa, Ricardo Jorge Ferreira
Ageing
Alzheimer´s disease
Astrocytes
Microglia
Pathology
Ciências Médicas::Medicina Básica
Science & Technology
title_short Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
title_full Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
title_fullStr Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
title_full_unstemmed Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
title_sort Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
author Taipa, Ricardo Jorge Ferreira
author_facet Taipa, Ricardo Jorge Ferreira
Ferreira, V.
Brochado, P.
Robinson, A
Reis, I.
Marques, Fernanda
Mann, D. M.
Melo-Pires, M.
Sousa, Nuno
author_role author
author2 Ferreira, V.
Brochado, P.
Robinson, A
Reis, I.
Marques, Fernanda
Mann, D. M.
Melo-Pires, M.
Sousa, Nuno
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Taipa, Ricardo Jorge Ferreira
Ferreira, V.
Brochado, P.
Robinson, A
Reis, I.
Marques, Fernanda
Mann, D. M.
Melo-Pires, M.
Sousa, Nuno
dc.subject.por.fl_str_mv Ageing
Alzheimer´s disease
Astrocytes
Microglia
Pathology
Ciências Médicas::Medicina Básica
Science & Technology
topic Ageing
Alzheimer´s disease
Astrocytes
Microglia
Pathology
Ciências Médicas::Medicina Básica
Science & Technology
description The association between the pathological features of AD and dementia is stronger in younger old persons than in older old persons suggesting that additional factors are involved in the clinical expression of dementia in the oldest old. Cumulative data suggests that neuroinflammation plays a prominent role in Alzheimer's disease (AD) and different studies reported an age-associated dysregulation of the neuroimmune system. Consequently, we sought to characterize the pattern of microglial cell activation and astrogliosis in brain post mortem tissue of pathologically confirmed cases of early and late onset AD (EOAD and LOAD) and determine their relation to age.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/57951
url http://hdl.handle.net/1822/57951
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Taipa, R., Ferreira, V., Brochado, P., Robinson, A., Reis, I., Marques, F., ... & Sousa, N. (2018). Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study. Neuropathology and applied neurobiology, 44(3), 298-313
0305-1846
1365-2990
10.1111/nan.12445
29044639
https://onlinelibrary.wiley.com/doi/full/10.1111/nan.12445
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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