The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin

Detalhes bibliográficos
Autor(a) principal: Serrano, Isa D.
Data de Publicação: 2014
Outros Autores: Freire, João M., Carvalho, Miguel V., Neves, Mafalda, Melo, Manuel N., Castanho, Miguel A. R. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/23447
Resumo: © 2014 Bentham Science Publishers
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spelling The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphinBlood-tissue barriersDrugKineticsKyotorphinPermeabilityTransepithelial transport© 2014 Bentham Science PublishersThis paper addresses the mechanisms behind selective endothelial permeability and their regulations. The singular properties of each of the seven blood-tissues barriers. Then, it further revisits the physical, quantitative meaning of permeability, and the way it should be measured based on sound physical chemistry reasoning and methodologies. Despite the relevance of permeability studies one often comes across inaccurate determinations, mostly from oversimplified data analyses. To worsen matters, the exact meaning of permeability is being lost along with this loss of accuracy. The importance of proper permeability calculation is illustrated with a family of derivatives of kyotorphin, an analgesic dipeptide.The authors thank to Fundação para a Ciência e Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) and EC-FP7 Marie Curie Industry-Academia Partnerships and Pathways (IAPP), Grant nº 230654 – Pep2Brain for financial support to the projects PTDC/QUI/69937/2006 and PTDC/QUI-BIQ/112929/2009. FCT-MCTES is also acknowledged for funding Post-doc fellowship SFRH/BPD/37998/2007 to I. Serrano and PhD fellowship SFRH/BD/70423/2010 to J. Freire.Bentham Science PublishersRepositório da Universidade de LisboaSerrano, Isa D.Freire, João M.Carvalho, Miguel V.Neves, MafaldaMelo, Manuel N.Castanho, Miguel A. R. B.2016-04-19T13:35:33Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/23447engMini-Reviews in Medicinal Chemistry, 2014, 14, 99-1101389-557510.2174/1389557514666140123130058metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:11:28Zoai:repositorio.ul.pt:10451/23447Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:40:47.780732Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin
title The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin
spellingShingle The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin
Serrano, Isa D.
Blood-tissue barriers
Drug
Kinetics
Kyotorphin
Permeability
Transepithelial transport
title_short The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin
title_full The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin
title_fullStr The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin
title_full_unstemmed The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin
title_sort The mechanisms and quantification of the selective permeability in transport across biological barriers : the example of kyotorphin
author Serrano, Isa D.
author_facet Serrano, Isa D.
Freire, João M.
Carvalho, Miguel V.
Neves, Mafalda
Melo, Manuel N.
Castanho, Miguel A. R. B.
author_role author
author2 Freire, João M.
Carvalho, Miguel V.
Neves, Mafalda
Melo, Manuel N.
Castanho, Miguel A. R. B.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Serrano, Isa D.
Freire, João M.
Carvalho, Miguel V.
Neves, Mafalda
Melo, Manuel N.
Castanho, Miguel A. R. B.
dc.subject.por.fl_str_mv Blood-tissue barriers
Drug
Kinetics
Kyotorphin
Permeability
Transepithelial transport
topic Blood-tissue barriers
Drug
Kinetics
Kyotorphin
Permeability
Transepithelial transport
description © 2014 Bentham Science Publishers
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2016-04-19T13:35:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/23447
url http://hdl.handle.net/10451/23447
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mini-Reviews in Medicinal Chemistry, 2014, 14, 99-110
1389-5575
10.2174/1389557514666140123130058
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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