The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil

Detalhes bibliográficos
Autor(a) principal: Costa, Daniela Nunes
Data de Publicação: 2016
Outros Autores: Alarico, Susana, Dalcolmo, Margareth Pretti, Neves, Margarida Correia, Empadinhas, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/46293
Resumo: Nontuberculous mycobacteria (NTM) are widely disseminated in the environment and an emerging cause of infectious diseases worldwide. Their remarkable natural resistance to disinfectants and antibiotics and an ability to survive under low-nutrient conditions allows NTM to colonize and persist in man-made environments such as household and hospital water distribution systems. This overlap between human and NTM environments afforded new opportunities for human exposure, and for expression of their often neglected and underestimated pathogenic potential. Some risk factors predisposing to NTM disease have been identified and are mainly associated with immune fragilities of the human host. However, infections in apparently immunocompetent persons are also increasingly reported. The purpose of this review is to bring attention to this emerging health problem in Portugal and Brazil and to emphasize the urgent need for increased surveillance and more comprehensive epidemiological data in both countries, where such information is scarce and seriously thwarts the adoption of proper preventive strategies and therapeutic options.
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spelling The looming tide of nontuberculous mycobacterial infections in Portugal and BrazilNontuberculous mycobacteriaEmerging infectionsOpportunistic pathogensMycobacteriosesPortugalBrazilScience & TechnologyNontuberculous mycobacteria (NTM) are widely disseminated in the environment and an emerging cause of infectious diseases worldwide. Their remarkable natural resistance to disinfectants and antibiotics and an ability to survive under low-nutrient conditions allows NTM to colonize and persist in man-made environments such as household and hospital water distribution systems. This overlap between human and NTM environments afforded new opportunities for human exposure, and for expression of their often neglected and underestimated pathogenic potential. Some risk factors predisposing to NTM disease have been identified and are mainly associated with immune fragilities of the human host. However, infections in apparently immunocompetent persons are also increasingly reported. The purpose of this review is to bring attention to this emerging health problem in Portugal and Brazil and to emphasize the urgent need for increased surveillance and more comprehensive epidemiological data in both countries, where such information is scarce and seriously thwarts the adoption of proper preventive strategies and therapeutic options.We acknowledge the support of FEDER through COMPETE and of National Funds through FCT - Fundacao para a Ciencia e a Tecnologia grants FCOMP-01-0124-FEDER-028359 [PTDC/BIA-MIC/2779/2012] and UID/NEU/04539/2013.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoCosta, Daniela NunesAlarico, SusanaDalcolmo, Margareth PrettiNeves, Margarida CorreiaEmpadinhas, Nuno20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/46293eng1472-979210.1016/j.tube.2015.09.00626560840http://www.journals.elsevier.com/tuberculosis/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:57:59Zoai:repositorium.sdum.uminho.pt:1822/46293Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:47:40.179292Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil
title The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil
spellingShingle The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil
Costa, Daniela Nunes
Nontuberculous mycobacteria
Emerging infections
Opportunistic pathogens
Mycobacterioses
Portugal
Brazil
Science & Technology
title_short The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil
title_full The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil
title_fullStr The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil
title_full_unstemmed The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil
title_sort The looming tide of nontuberculous mycobacterial infections in Portugal and Brazil
author Costa, Daniela Nunes
author_facet Costa, Daniela Nunes
Alarico, Susana
Dalcolmo, Margareth Pretti
Neves, Margarida Correia
Empadinhas, Nuno
author_role author
author2 Alarico, Susana
Dalcolmo, Margareth Pretti
Neves, Margarida Correia
Empadinhas, Nuno
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Costa, Daniela Nunes
Alarico, Susana
Dalcolmo, Margareth Pretti
Neves, Margarida Correia
Empadinhas, Nuno
dc.subject.por.fl_str_mv Nontuberculous mycobacteria
Emerging infections
Opportunistic pathogens
Mycobacterioses
Portugal
Brazil
Science & Technology
topic Nontuberculous mycobacteria
Emerging infections
Opportunistic pathogens
Mycobacterioses
Portugal
Brazil
Science & Technology
description Nontuberculous mycobacteria (NTM) are widely disseminated in the environment and an emerging cause of infectious diseases worldwide. Their remarkable natural resistance to disinfectants and antibiotics and an ability to survive under low-nutrient conditions allows NTM to colonize and persist in man-made environments such as household and hospital water distribution systems. This overlap between human and NTM environments afforded new opportunities for human exposure, and for expression of their often neglected and underestimated pathogenic potential. Some risk factors predisposing to NTM disease have been identified and are mainly associated with immune fragilities of the human host. However, infections in apparently immunocompetent persons are also increasingly reported. The purpose of this review is to bring attention to this emerging health problem in Portugal and Brazil and to emphasize the urgent need for increased surveillance and more comprehensive epidemiological data in both countries, where such information is scarce and seriously thwarts the adoption of proper preventive strategies and therapeutic options.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/46293
url http://hdl.handle.net/1822/46293
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1472-9792
10.1016/j.tube.2015.09.006
26560840
http://www.journals.elsevier.com/tuberculosis/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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