Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.21/16096 |
Resumo: | Correção em https://doi.org/10.1007/s40199-023-00469-9 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studiesCOVID-19CoronavirusFlavonoidsIn silicoRespiratory syndromeCorreção em https://doi.org/10.1007/s40199-023-00469-9Objectives: This scoping review aims to present flavonoid compounds' promising effects and possible mechanisms of action on potential therapeutic targets in the SARS-CoV-2 infection process. Methods: A search of electronic databases such as PubMed and Scopus was carried out to evaluate the performance of substances from the flavonoid class at different stages of SARS-CoV-2 infection. Results: The search strategy yielded 382 articles after the exclusion of duplicates. During the screening process, 265 records were deemed as irrelevant. At the end of the full-text appraisal, 37 studies were considered eligible for data extraction and qualitative synthesis. All the studies used virtual molecular docking models to verify the affinity of compounds from the flavonoid class with crucial proteins in the replication cycle of the SARS-CoV-2 virus (Spike protein, PLpro, 3CLpro/ MPro, RdRP, and inhibition of the host's ACE II receptor). The flavonoids with more targets and lowest binding energies were: orientin, quercetin, epigallocatechin, narcissoside, silymarin, neohesperidin, delphinidin-3,5-diglucoside, and delphinidin-3-sambubioside-5-glucoside. Conclusion: These studies allow us to provide a basis for in vitro and in vivo assays to assist in developing drugs for the treatment and prevention of COVID-19.This study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científco e Tecnológico (CNPq). We would like to thank the Programa de Graduação em Ciências Farmacêuticas at Universidade Estadual do Oeste do Paraná, Universidade Estadual de Maringá, Centro Universitário Ingá, Universidade do Porto and Universidade Federal do Paraná.SpringerRCIPLToigo, LarissaTeodoro, Emilly Isabelli dos SantosGuidi, Ana CarolinaGancedo, Naiara CássiaPetruco, Marcus ViníciusMelo, Eduardo BorgesTonin, FernandaFernandez-Llimos, FernandoChierrito, DaniellyMello, João Carlos Palazzo deAraújo, Daniela Cristina de MedeirosSanches, Andréia Cristina Conegero2023-05-22T11:57:17Z2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.21/16096engToigo L, Teodoro EI, Guidi AC, Gancedo NC, Petruco MV, Tonin FS, et al. Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies. Daru. 2023;31(1):51-68.10.1007/s40199-023-00461-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-30T02:15:43Zoai:repositorio.ipl.pt:10400.21/16096Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:23:41.662640Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies |
| title |
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies |
| spellingShingle |
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies Toigo, Larissa COVID-19 Coronavirus Flavonoids In silico Respiratory syndrome |
| title_short |
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies |
| title_full |
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies |
| title_fullStr |
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies |
| title_full_unstemmed |
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies |
| title_sort |
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies |
| author |
Toigo, Larissa |
| author_facet |
Toigo, Larissa Teodoro, Emilly Isabelli dos Santos Guidi, Ana Carolina Gancedo, Naiara Cássia Petruco, Marcus Vinícius Melo, Eduardo Borges Tonin, Fernanda Fernandez-Llimos, Fernando Chierrito, Danielly Mello, João Carlos Palazzo de Araújo, Daniela Cristina de Medeiros Sanches, Andréia Cristina Conegero |
| author_role |
author |
| author2 |
Teodoro, Emilly Isabelli dos Santos Guidi, Ana Carolina Gancedo, Naiara Cássia Petruco, Marcus Vinícius Melo, Eduardo Borges Tonin, Fernanda Fernandez-Llimos, Fernando Chierrito, Danielly Mello, João Carlos Palazzo de Araújo, Daniela Cristina de Medeiros Sanches, Andréia Cristina Conegero |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
RCIPL |
| dc.contributor.author.fl_str_mv |
Toigo, Larissa Teodoro, Emilly Isabelli dos Santos Guidi, Ana Carolina Gancedo, Naiara Cássia Petruco, Marcus Vinícius Melo, Eduardo Borges Tonin, Fernanda Fernandez-Llimos, Fernando Chierrito, Danielly Mello, João Carlos Palazzo de Araújo, Daniela Cristina de Medeiros Sanches, Andréia Cristina Conegero |
| dc.subject.por.fl_str_mv |
COVID-19 Coronavirus Flavonoids In silico Respiratory syndrome |
| topic |
COVID-19 Coronavirus Flavonoids In silico Respiratory syndrome |
| description |
Correção em https://doi.org/10.1007/s40199-023-00469-9 |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-05-22T11:57:17Z 2023-06 2023-06-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/16096 |
| url |
http://hdl.handle.net/10400.21/16096 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Toigo L, Teodoro EI, Guidi AC, Gancedo NC, Petruco MV, Tonin FS, et al. Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies. Daru. 2023;31(1):51-68. 10.1007/s40199-023-00461-3 |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Springer |
| publisher.none.fl_str_mv |
Springer |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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