Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNIOESTE |
Texto Completo: | https://tede.unioeste.br/handle/tede/6199 |
Resumo: | This scoping review aims to present the promising effects and possible targets of flavonoid compounds on potential therapeutic targets in the SARS-CoV-2 infection process. The PubMed and Scopus electronic databases were searched for studies that evaluated the performance of substances from the flavonoid class on different viral targets of SARS-CoV-2 infection. The search strategy retrieved 382 articles after deleting duplicates. During the screening process, 265 studies were considered irrelevant. At the end of the full-text evaluation, 37 studies were considered eligible for data extraction and qualitative synthesis. All studies used virtual molecular docking models to verify the affinity of compounds of the flavonoid class with key proteins in the replication cycle of the SARS-CoV-2 virus (Spike protein, PLpro, 3CLpro/MPro, RdRP and host ACE 2 in in silico studies). Studies on Spike protein evaluated a total of 26 different flavonoids, the most promising being: biochanin A (-78.41 kcal/mol); calofilolide and eriodictiol (-7.90 kcal/mol); fisetin (-8.50 kcal/mol); hesperidin (-7.4 kcal/mol); quercetin (-86.22 kcal/mol); luteolin (-7.00 kcal/mol); orientin (-72.30 kcal/mol). In the inhibition of PLpro, quercetin presented binding energies of -10.20 kcal/mol and -7.75 kcal/mol. Hesperidin had a binding energy of -9.40 kcal/mol and luteolin had a binding energy of -6.80 kcal/mol. Among the flavonoids with the potential to inhibit 3CLpro, those with the best results were amentoflavone, baicalein, cyanidin 3-rutinoside, hesperidin, kaempferol, luteolin, narcisoside, naringin, pectolinarin, quercetin and rhoifolin. Narcisoside has the highest binding energy -180.74 kcal/mol, epigallocatechin showed binding energy above -12.90 kcal/mol against RdRP and the most promising flavonoids that inhibit the host ACE 2 receptor were cyanide, delphinidin , orientin, quercetin, silymarin/silibinin (silybin A) and theaflavin monogallate with binding energies ranging from -4.76 kcal/mol to -121.28 kcal/mol. The flavonoids that presented the lowest binding energies and the highest number of targets were orientin, quercetin, epigallocatechin, narcisoside, silymarin, neohesperidin, delphinidin-3,5-diglycoside and delphinidin-3-sambubioside-5- glycoside. These studies allow us to provide a basis for in vitro and in vivo trials to assist in the development of drugs for the treatment and/or prevention of coronavirus disease (COVID-19). |
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Sanches, Andreia Cristina Conegerohttp://lattes.cnpq.br/9706216109598342Fariña, Luciana Oliveira dehttp://lattes.cnpq.br/2043990245681647Tolentino, Danielly Chierrito de Oliveirahttp://lattes.cnpq.br/2007735848876377http://lattes.cnpq.br/4146668831721007Toigo, Larissa2022-09-20T12:32:45Z2022-07-15Toigo, Larissa. Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo. 2022. 103 f. Dissertação( Mestrado em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel, 2022.https://tede.unioeste.br/handle/tede/6199This scoping review aims to present the promising effects and possible targets of flavonoid compounds on potential therapeutic targets in the SARS-CoV-2 infection process. The PubMed and Scopus electronic databases were searched for studies that evaluated the performance of substances from the flavonoid class on different viral targets of SARS-CoV-2 infection. The search strategy retrieved 382 articles after deleting duplicates. During the screening process, 265 studies were considered irrelevant. At the end of the full-text evaluation, 37 studies were considered eligible for data extraction and qualitative synthesis. All studies used virtual molecular docking models to verify the affinity of compounds of the flavonoid class with key proteins in the replication cycle of the SARS-CoV-2 virus (Spike protein, PLpro, 3CLpro/MPro, RdRP and host ACE 2 in in silico studies). Studies on Spike protein evaluated a total of 26 different flavonoids, the most promising being: biochanin A (-78.41 kcal/mol); calofilolide and eriodictiol (-7.90 kcal/mol); fisetin (-8.50 kcal/mol); hesperidin (-7.4 kcal/mol); quercetin (-86.22 kcal/mol); luteolin (-7.00 kcal/mol); orientin (-72.30 kcal/mol). In the inhibition of PLpro, quercetin presented binding energies of -10.20 kcal/mol and -7.75 kcal/mol. Hesperidin had a binding energy of -9.40 kcal/mol and luteolin had a binding energy of -6.80 kcal/mol. Among the flavonoids with the potential to inhibit 3CLpro, those with the best results were amentoflavone, baicalein, cyanidin 3-rutinoside, hesperidin, kaempferol, luteolin, narcisoside, naringin, pectolinarin, quercetin and rhoifolin. Narcisoside has the highest binding energy -180.74 kcal/mol, epigallocatechin showed binding energy above -12.90 kcal/mol against RdRP and the most promising flavonoids that inhibit the host ACE 2 receptor were cyanide, delphinidin , orientin, quercetin, silymarin/silibinin (silybin A) and theaflavin monogallate with binding energies ranging from -4.76 kcal/mol to -121.28 kcal/mol. The flavonoids that presented the lowest binding energies and the highest number of targets were orientin, quercetin, epigallocatechin, narcisoside, silymarin, neohesperidin, delphinidin-3,5-diglycoside and delphinidin-3-sambubioside-5- glycoside. These studies allow us to provide a basis for in vitro and in vivo trials to assist in the development of drugs for the treatment and/or prevention of coronavirus disease (COVID-19).Esta revisão de escopo visa apresentar os efeitos promissores e os possíveis alvos dos compostos flavonoides sobre potenciais alvos terapêuticos no processo de infecção por SARS-CoV-2. As bases de dados eletrônicas PubMed e Scopus foram pesquisadas por estudos que avaliaram o desempenho de substâncias da classe dos flavonoides em diferentes alvos virais da infecção por SARS-CoV-2. A estratégia de busca recuperou 382 artigos, após a exclusão de duplicatas. Durante o processo de triagem, 265 estudos foram considerados irrelevantes. Ao final da avaliação do texto completo, 37 estudos foram considerados elegíveis para extração de dados e síntese qualitativa. Todos os estudos utilizaram modelos de docking molecular virtual para verificar a afinidade de compostos da classe dos flavonoides com proteínas-chave no ciclo de replicação do vírus SARS-CoV-2 (proteína Spike, PLpro, 3CLpro/MPro, RdRP e inibição do receptor da ECA 2 do hospedeiro, nos estudos in sílico). Estudos sobre a proteína Spike avaliaram um total de 26 flavonoides diferentes, sendo os mais promissores: biochanina A (-78,41 kcal/mol); calofilolide e eriodictiol (-7,90 kcal/mol); fisetina (-8,50 kcal/mol); hesperidina (-7,4 kcal/mol); quercetina (-86,22 kcal/mol); luteolina (-7,00 kcal/mol); orientina (-72,30 kcal/mol). Na inibição da PLpro, a quercetina apresentou as energias de ligação de -10,20 kcal/mol e -7,75 kcal/mol. A hesperidina teve energia de ligação de -9,40 kcal/mol e luteolina com energia de ligação de -6,80 kcal/mol. Dentre os flavonoides com potencial para inibir 3CLpro, os que apresentaram os melhores resultados foram amentoflavona, baicaleína, cianidina 3-rutinosídeo, hesperidina, campferol, luteolina, narcisosídeo, naringina, pectolinarina, quercetina e rhoifolina. O narcisosídeo tem a maior energia de ligação -180,74 kcal/mol, a epigalocatequina apresentou energia de ligação acima de -12,90 kcal/mol contra RdRP e os flavonoides mais promissores que inibem o receptor ECA 2 do hospedeiro foram cianeto, delfinidina, orientina, quercetina, silimarina/silibinina (silibina A) e monogalato de teaflavina com energias de ligação variando de -4,76 kcal/mol a -121,28 kcal/mol. Os flavonoides que apresentaram as menores energias de ligação e maior número de alvos foram orientina, quercetina, epigalocatequina, narcisosídeo, silimarina, neohesperidina, delfinidina-3,5-diglicosídeo e delfinidina-3- sambubiosídeo-5-glicosídeo. Esses estudos nos permitem fornecer uma base para ensaios in vitro e in vivo para auxiliar no desenvolvimento de medicamentos para o tratamento e/ou prevenção da doença causada pelo coronavírus (COVID-19).Submitted by Edineia Teixeira (edineia.teixeira@unioeste.br) on 2022-09-20T12:32:45Z No. of bitstreams: 2 Larissa_Toligo2022.pdf: 1501157 bytes, checksum: 991f5e0cc0d0733e61ca346131b96f76 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2022-09-20T12:32:45Z (GMT). No. of bitstreams: 2 Larissa_Toligo2022.pdf: 1501157 bytes, checksum: 991f5e0cc0d0733e61ca346131b96f76 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2022-07-15Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfpor6588633818200016417500Universidade Estadual do Oeste do ParanáCascavelPrograma de Pós-Graduação em Ciências FarmacêuticasUNIOESTEBrasilCentro de Ciências Médicas e Farmacêuticashttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessCoronavírusSíndrome RespiratóriaPlantas medicinaisBioativosIn sílicoCoronavirusRespiratory SyndromeMedicinal PlantsBioactivesIn sílicoCiências farmacêuticasFlavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopoFlavonoids as possible therapeutic targets against coronavírus disease (COVID 19): a scoping revinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis7878055067573953101600600600-89404397133878492672075167498588264571reponame:Biblioteca Digital de Teses e Dissertações do UNIOESTEinstname:Universidade Estadual do Oeste do Paraná (UNIOESTE)instacron:UNIOESTEORIGINALLarissa_Toligo2022.pdfLarissa_Toligo2022.pdfapplication/pdf1501157http://tede.unioeste.br:8080/tede/bitstream/tede/6199/6/Larissa_Toligo2022.pdf991f5e0cc0d0733e61ca346131b96f76MD56LICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo |
dc.title.alternative.eng.fl_str_mv |
Flavonoids as possible therapeutic targets against coronavírus disease (COVID 19): a scoping rev |
title |
Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo |
spellingShingle |
Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo Toigo, Larissa Coronavírus Síndrome Respiratória Plantas medicinais Bioativos In sílico Coronavirus Respiratory Syndrome Medicinal Plants Bioactives In sílico Ciências farmacêuticas |
title_short |
Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo |
title_full |
Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo |
title_fullStr |
Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo |
title_full_unstemmed |
Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo |
title_sort |
Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo |
author |
Toigo, Larissa |
author_facet |
Toigo, Larissa |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Sanches, Andreia Cristina Conegero |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9706216109598342 |
dc.contributor.referee1.fl_str_mv |
Fariña, Luciana Oliveira de |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2043990245681647 |
dc.contributor.referee2.fl_str_mv |
Tolentino, Danielly Chierrito de Oliveira |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2007735848876377 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4146668831721007 |
dc.contributor.author.fl_str_mv |
Toigo, Larissa |
contributor_str_mv |
Sanches, Andreia Cristina Conegero Fariña, Luciana Oliveira de Tolentino, Danielly Chierrito de Oliveira |
dc.subject.por.fl_str_mv |
Coronavírus Síndrome Respiratória Plantas medicinais Bioativos In sílico |
topic |
Coronavírus Síndrome Respiratória Plantas medicinais Bioativos In sílico Coronavirus Respiratory Syndrome Medicinal Plants Bioactives In sílico Ciências farmacêuticas |
dc.subject.eng.fl_str_mv |
Coronavirus Respiratory Syndrome Medicinal Plants Bioactives In sílico |
dc.subject.cnpq.fl_str_mv |
Ciências farmacêuticas |
description |
This scoping review aims to present the promising effects and possible targets of flavonoid compounds on potential therapeutic targets in the SARS-CoV-2 infection process. The PubMed and Scopus electronic databases were searched for studies that evaluated the performance of substances from the flavonoid class on different viral targets of SARS-CoV-2 infection. The search strategy retrieved 382 articles after deleting duplicates. During the screening process, 265 studies were considered irrelevant. At the end of the full-text evaluation, 37 studies were considered eligible for data extraction and qualitative synthesis. All studies used virtual molecular docking models to verify the affinity of compounds of the flavonoid class with key proteins in the replication cycle of the SARS-CoV-2 virus (Spike protein, PLpro, 3CLpro/MPro, RdRP and host ACE 2 in in silico studies). Studies on Spike protein evaluated a total of 26 different flavonoids, the most promising being: biochanin A (-78.41 kcal/mol); calofilolide and eriodictiol (-7.90 kcal/mol); fisetin (-8.50 kcal/mol); hesperidin (-7.4 kcal/mol); quercetin (-86.22 kcal/mol); luteolin (-7.00 kcal/mol); orientin (-72.30 kcal/mol). In the inhibition of PLpro, quercetin presented binding energies of -10.20 kcal/mol and -7.75 kcal/mol. Hesperidin had a binding energy of -9.40 kcal/mol and luteolin had a binding energy of -6.80 kcal/mol. Among the flavonoids with the potential to inhibit 3CLpro, those with the best results were amentoflavone, baicalein, cyanidin 3-rutinoside, hesperidin, kaempferol, luteolin, narcisoside, naringin, pectolinarin, quercetin and rhoifolin. Narcisoside has the highest binding energy -180.74 kcal/mol, epigallocatechin showed binding energy above -12.90 kcal/mol against RdRP and the most promising flavonoids that inhibit the host ACE 2 receptor were cyanide, delphinidin , orientin, quercetin, silymarin/silibinin (silybin A) and theaflavin monogallate with binding energies ranging from -4.76 kcal/mol to -121.28 kcal/mol. The flavonoids that presented the lowest binding energies and the highest number of targets were orientin, quercetin, epigallocatechin, narcisoside, silymarin, neohesperidin, delphinidin-3,5-diglycoside and delphinidin-3-sambubioside-5- glycoside. These studies allow us to provide a basis for in vitro and in vivo trials to assist in the development of drugs for the treatment and/or prevention of coronavirus disease (COVID-19). |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-09-20T12:32:45Z |
dc.date.issued.fl_str_mv |
2022-07-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Toigo, Larissa. Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo. 2022. 103 f. Dissertação( Mestrado em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel, 2022. |
dc.identifier.uri.fl_str_mv |
https://tede.unioeste.br/handle/tede/6199 |
identifier_str_mv |
Toigo, Larissa. Flavonoides como possíveis alvos terapêuticos contra a doença do coronavírus (COVID-19): uma revisão de escopo. 2022. 103 f. Dissertação( Mestrado em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel, 2022. |
url |
https://tede.unioeste.br/handle/tede/6199 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
7878055067573953101 |
dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
-8940439713387849267 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual do Oeste do Paraná Cascavel |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Farmacêuticas |
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UNIOESTE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Centro de Ciências Médicas e Farmacêuticas |
publisher.none.fl_str_mv |
Universidade Estadual do Oeste do Paraná Cascavel |
dc.source.none.fl_str_mv |
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Universidade Estadual do Oeste do Paraná (UNIOESTE) |
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UNIOESTE |
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UNIOESTE |
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Biblioteca Digital de Teses e Dissertações do UNIOESTE |
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Biblioteca Digital de Teses e Dissertações do UNIOESTE |
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Biblioteca Digital de Teses e Dissertações do UNIOESTE - Universidade Estadual do Oeste do Paraná (UNIOESTE) |
repository.mail.fl_str_mv |
biblioteca.repositorio@unioeste.br |
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