Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases

Detalhes bibliográficos
Autor(a) principal: Leitão, Ana
Data de Publicação: 2015
Outros Autores: Costa, Marina C., Enguita, Francisco J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/51736
Resumo: © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
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spelling Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicasesRNA helicaseStructural biologyProtein-RNA complexDEAD-box proteinInnate immunityRIG-I© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).The centrality of RNA within the biological world is an irrefutable fact that currently attracts increasing attention from the scientific community. The panoply of functional RNAs requires the existence of specific biological caretakers, RNA helicases, devoted to maintain the proper folding of those molecules, resolving unstable structures. However, evolution has taken advantage of the specific position and characteristics of RNA helicases to develop new functions for these proteins, which are at the interface of the basic processes for transference of information from DNA to proteins. RNA helicases are involved in many biologically relevant processes, not only as RNA chaperones, but also as signal transducers, scaffolds of molecular complexes, and regulatory elements. Structural biology studies during the last decade, founded in X-ray crystallography, have characterized in detail several RNA-helicases. This comprehensive review summarizes the structural knowledge accumulated in the last two decades within this family of proteins, with special emphasis on the structure-function relationships of the most widely-studied families of RNA helicases: the DEAD-box, RIG-I-like and viral NS3 classes.Marina C. Costa was supported by a post-doctoral fellowship from Fundação para a Ciência e Tecnologia, Portugal (Ref. SFRH/BPD/65131/2009).MDPIRepositório da Universidade de LisboaLeitão, AnaCosta, Marina C.Enguita, Francisco J.2022-03-14T16:52:31Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/51736engInt J Mol Sci. 2015 Jan 22;16(2):2269-22931661-659610.3390/ijms160222691422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:56:37Zoai:repositorio.ul.pt:10451/51736Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:59.162772Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases
title Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases
spellingShingle Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases
Leitão, Ana
RNA helicase
Structural biology
Protein-RNA complex
DEAD-box protein
Innate immunity
RIG-I
title_short Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases
title_full Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases
title_fullStr Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases
title_full_unstemmed Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases
title_sort Unzippers, resolvers and sensors: a structural and functional biochemistry tale of RNA helicases
author Leitão, Ana
author_facet Leitão, Ana
Costa, Marina C.
Enguita, Francisco J.
author_role author
author2 Costa, Marina C.
Enguita, Francisco J.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Leitão, Ana
Costa, Marina C.
Enguita, Francisco J.
dc.subject.por.fl_str_mv RNA helicase
Structural biology
Protein-RNA complex
DEAD-box protein
Innate immunity
RIG-I
topic RNA helicase
Structural biology
Protein-RNA complex
DEAD-box protein
Innate immunity
RIG-I
description © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2022-03-14T16:52:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/51736
url http://hdl.handle.net/10451/51736
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Mol Sci. 2015 Jan 22;16(2):2269-2293
1661-6596
10.3390/ijms16022269
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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