N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents

Detalhes bibliográficos
Autor(a) principal: Vale Costa, S
Data de Publicação: 2013
Outros Autores: Costa Gouveia, J, Perez, B, Silva, T, Teixeira, C, Gomes, P, Gomes, MS
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/82082
Resumo: A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.
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spelling N-Cinnamoylated Aminoquinolines as Promising Antileishmanial AgentsMedicina básicaBasic medicineA series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/82082eng0066-480410.1128/aac.00557-13Vale Costa, SCosta Gouveia, JPerez, BSilva, TTeixeira, CGomes, PGomes, MSinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:36:37Zoai:repositorio-aberto.up.pt:10216/82082Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:05:06.701508Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
spellingShingle N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
Vale Costa, S
Medicina básica
Basic medicine
title_short N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title_full N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title_fullStr N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title_full_unstemmed N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title_sort N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
author Vale Costa, S
author_facet Vale Costa, S
Costa Gouveia, J
Perez, B
Silva, T
Teixeira, C
Gomes, P
Gomes, MS
author_role author
author2 Costa Gouveia, J
Perez, B
Silva, T
Teixeira, C
Gomes, P
Gomes, MS
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vale Costa, S
Costa Gouveia, J
Perez, B
Silva, T
Teixeira, C
Gomes, P
Gomes, MS
dc.subject.por.fl_str_mv Medicina básica
Basic medicine
topic Medicina básica
Basic medicine
description A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/82082
url https://hdl.handle.net/10216/82082
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0066-4804
10.1128/aac.00557-13
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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