N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents

Detalhes bibliográficos
Autor(a) principal: Vale-Costa, S.
Data de Publicação: 2013
Outros Autores: Costa-Gouveia, J., Perez, B., Silva, T., Teixeira, C., Gomes, P., Gomes, M. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/19340
Resumo: A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.
id RCAP_8880c75efd9d0284b7bdba6810f9d1c8
oai_identifier_str oai:ria.ua.pt:10773/19340
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling N-Cinnamoylated Aminoquinolines as Promising Antileishmanial AgentsVISCERAL LEISHMANIASISDIAGNOSISDRUGSA series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.AMER SOC MICROBIOLOGY2017-12-07T19:09:23Z2013-01-01T00:00:00Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/19340eng0066-480410.1128/AAC.00557-13Vale-Costa, S.Costa-Gouveia, J.Perez, B.Silva, T.Teixeira, C.Gomes, P.Gomes, M. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:37:32Zoai:ria.ua.pt:10773/19340Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:54:08.280112Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
spellingShingle N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
Vale-Costa, S.
VISCERAL LEISHMANIASIS
DIAGNOSIS
DRUGS
title_short N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title_full N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title_fullStr N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title_full_unstemmed N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
title_sort N-Cinnamoylated Aminoquinolines as Promising Antileishmanial Agents
author Vale-Costa, S.
author_facet Vale-Costa, S.
Costa-Gouveia, J.
Perez, B.
Silva, T.
Teixeira, C.
Gomes, P.
Gomes, M. S.
author_role author
author2 Costa-Gouveia, J.
Perez, B.
Silva, T.
Teixeira, C.
Gomes, P.
Gomes, M. S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vale-Costa, S.
Costa-Gouveia, J.
Perez, B.
Silva, T.
Teixeira, C.
Gomes, P.
Gomes, M. S.
dc.subject.por.fl_str_mv VISCERAL LEISHMANIASIS
DIAGNOSIS
DRUGS
topic VISCERAL LEISHMANIASIS
DIAGNOSIS
DRUGS
description A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 mu M) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 mu M) of Leishmania infantum. Both the high activity of these chloroquine analogues and their mild-to-low toxicity toward host cells make them promising leads for the discovery of new antileishmanial agents.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01T00:00:00Z
2013
2017-12-07T19:09:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/19340
url http://hdl.handle.net/10773/19340
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0066-4804
10.1128/AAC.00557-13
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv AMER SOC MICROBIOLOGY
publisher.none.fl_str_mv AMER SOC MICROBIOLOGY
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137593510592512

Registros relacionados