Regulatory T-cell development in the human thymus

Detalhes bibliográficos
Autor(a) principal: Caramalho, Íris
Data de Publicação: 2015
Outros Autores: Nunes-Cabaço, Helena, Foxall, Russell B., Sousa, Ana E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/20122
Resumo: © 2015 Caramalho, Nunes-Cabaço, Foxall and Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Regulatory T-cell development in the human thymusHuman thymusRegulatory T-cellsFOXP3Regulatory T-cell developmentHuman thymic defectsPrimary immunodeficiency© 2015 Caramalho, Nunes-Cabaço, Foxall and Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.The thymus generates a lineage-committed subset of regulatory T-cells (Tregs), best identified by the expression of the transcription factor FOXP3. The development of thymus-derived Tregs is known to require high-avidity interaction with MHC-self peptides leading to the generation of self-reactive Tregs fundamental for the maintenance of self-tolerance. Notwithstanding their crucial role in the control of immune responses, human thymic Treg differentiation remains poorly understood. In this mini-review, we will focus on the developmental stages at which Treg lineage commitment occurs, and their spatial localization in the human thymus, reviewing the molecular requirements, including T-cell receptor and cytokine signaling, as well as the cellular interactions involved. An overview of the impact of described thymic defects on the Treg compartment will be provided, illustrating the importance of these in vivo models to investigate human Treg development.IC, HN-C, and RBF received scholarships from Fundação para a Ciência e a Tecnologia (FCT) cofinanced by Programa Operacional Ciência e Inovação 2010 (POCI2010).FrontiersRepositório da Universidade de LisboaCaramalho, ÍrisNunes-Cabaço, HelenaFoxall, Russell B.Sousa, Ana E.2015-09-23T10:33:33Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/20122engFrontiers in Immunology | August 2015 | Volume 6 | Article 3951664-3224http://dx.doi.org/10.3389/fimmu.2015.00395info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:05:13Zoai:repositorio.ul.pt:10451/20122Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:38:12.815288Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Regulatory T-cell development in the human thymus
title Regulatory T-cell development in the human thymus
spellingShingle Regulatory T-cell development in the human thymus
Caramalho, Íris
Human thymus
Regulatory T-cells
FOXP3
Regulatory T-cell development
Human thymic defects
Primary immunodeficiency
title_short Regulatory T-cell development in the human thymus
title_full Regulatory T-cell development in the human thymus
title_fullStr Regulatory T-cell development in the human thymus
title_full_unstemmed Regulatory T-cell development in the human thymus
title_sort Regulatory T-cell development in the human thymus
author Caramalho, Íris
author_facet Caramalho, Íris
Nunes-Cabaço, Helena
Foxall, Russell B.
Sousa, Ana E.
author_role author
author2 Nunes-Cabaço, Helena
Foxall, Russell B.
Sousa, Ana E.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Caramalho, Íris
Nunes-Cabaço, Helena
Foxall, Russell B.
Sousa, Ana E.
dc.subject.por.fl_str_mv Human thymus
Regulatory T-cells
FOXP3
Regulatory T-cell development
Human thymic defects
Primary immunodeficiency
topic Human thymus
Regulatory T-cells
FOXP3
Regulatory T-cell development
Human thymic defects
Primary immunodeficiency
description © 2015 Caramalho, Nunes-Cabaço, Foxall and Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2015
dc.date.none.fl_str_mv 2015-09-23T10:33:33Z
2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/20122
url http://hdl.handle.net/10451/20122
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers in Immunology | August 2015 | Volume 6 | Article 395
1664-3224
http://dx.doi.org/10.3389/fimmu.2015.00395
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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