Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications

Detalhes bibliográficos
Autor(a) principal: Correia, D. M.
Data de Publicação: 2016
Outros Autores: Sencadas, Vítor João Gomes Silva, Ribeiro, C., Martins, P. M., Martins, P., Gama, F. M., Botelho, Gabriela, Lanceros-Méndez, S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/41807
Resumo: "Available online 11 May 2016"
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spelling Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applicationsBiocompatibilityPoly(L-lactic acid) microspheresOil in water emulsion techniqueCell viabilityMagnetic nanocompositesScience & Technology"Available online 11 May 2016"Biodegradable poly(L-lactic acid) (PLLA) and PLLA/CoFe2O4 magnetic microspheres with average sizes ranging between 0.16 -3.9 m and 0.8-2.2 m, respectively, were obtained by an oil-in-water emulsion method using poly(vinyl alcohol) (PVA) solution as the emulsifier agent. The separation of the microspheres in different size ranges was then performed by centrifugation and the colloidal stability assessed at different pH values. Neat PLLA spheres are more stable in alkaline environments when compared to magnetic microspheres, both types being stable for pHs higher than 4, resulting in a colloidal suspension. On the other hand, in acidic environments the microspheres tend to form aggregates. The neat PLLA microspheres show a degree of crystallinity of 40% whereas the composite ones are nearly amorphous (17%). Finally, the biocompatibility was assessed by cell viability studies with MC3T3-E1 pre-osteoblast cells.This work is funded by FCT – Fundação para a Ciência e a Tecnologia, grants SFRH/BD/82411/2011 (DMC), SFRH/ BPD/90870/2012 (CR), SFRH/BD/98616/2013 (PMM) and SFRH/ BPD/97739/2013 (PM), respectively. The authors thank support from the COST Action MP1206 ‘‘Electrospun Nano-fibres for bio inspired composite materials and innovative industrial applications” and from the Basque Government Industry Department under the ELKARTEK Program. SLM thanks the Diputación Foral de Bizkaia for financial support under the Bizkaia Talent Programme; European Union’s Seventh Framework Programme; Marie Curie Actions–People; Grant agreement no. 267230.ElsevierUniversidade do MinhoCorreia, D. M.Sencadas, Vítor João Gomes SilvaRibeiro, C.Martins, P. M.Martins, P.Gama, F. M.Botelho, GabrielaLanceros-Méndez, S.20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/41807engCorreia, D. M.; Sencadas, V.; Ribeiro, C.; Martins, P.; Martins, P.; Gama, F. M.; Botelho, G.; Lanceros-Méndez, S., Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications. Journal of Colloid and Interface Science, 476, 79-86, 20160021-97971095-710310.1016/j.jcis.2016.05.01227209393http://www.journals.elsevier.com/journal-of-colloid-and-interface-scienceinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:37:39Zoai:repositorium.sdum.uminho.pt:1822/41807Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:33:58.107739Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications
title Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications
spellingShingle Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications
Correia, D. M.
Biocompatibility
Poly(L-lactic acid) microspheres
Oil in water emulsion technique
Cell viability
Magnetic nanocomposites
Science & Technology
title_short Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications
title_full Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications
title_fullStr Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications
title_full_unstemmed Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications
title_sort Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications
author Correia, D. M.
author_facet Correia, D. M.
Sencadas, Vítor João Gomes Silva
Ribeiro, C.
Martins, P. M.
Martins, P.
Gama, F. M.
Botelho, Gabriela
Lanceros-Méndez, S.
author_role author
author2 Sencadas, Vítor João Gomes Silva
Ribeiro, C.
Martins, P. M.
Martins, P.
Gama, F. M.
Botelho, Gabriela
Lanceros-Méndez, S.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Correia, D. M.
Sencadas, Vítor João Gomes Silva
Ribeiro, C.
Martins, P. M.
Martins, P.
Gama, F. M.
Botelho, Gabriela
Lanceros-Méndez, S.
dc.subject.por.fl_str_mv Biocompatibility
Poly(L-lactic acid) microspheres
Oil in water emulsion technique
Cell viability
Magnetic nanocomposites
Science & Technology
topic Biocompatibility
Poly(L-lactic acid) microspheres
Oil in water emulsion technique
Cell viability
Magnetic nanocomposites
Science & Technology
description "Available online 11 May 2016"
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/41807
url http://hdl.handle.net/1822/41807
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Correia, D. M.; Sencadas, V.; Ribeiro, C.; Martins, P.; Martins, P.; Gama, F. M.; Botelho, G.; Lanceros-Méndez, S., Processing and size range separation of pristine and magnetic poly(L-lactic acid) based microspheres for biomedical applications. Journal of Colloid and Interface Science, 476, 79-86, 2016
0021-9797
1095-7103
10.1016/j.jcis.2016.05.012
27209393
http://www.journals.elsevier.com/journal-of-colloid-and-interface-science
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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