Blood derivatives awaken in regenerative medicine strategies to modulate wound healing
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/58737 |
Resumo: | Blood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awakened as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms. Herein, we highlight recent trends on the use biomaterials to protect, sequester and deliver these pools of biomolecules in tissue engineering and regenerative medicine approaches. Particular emphasis is given to strategies that enable to control their spatiotemporal delivery and improve the selectivity of presentation profiles of the biomolecules derived from blood derivatives rich in platelets. Finally, we discussed possible directions for biomaterials design to potentiate the aimed regenerative effects of blood derivatives and achieve efficient therapies. |
id |
RCAP_99412f2da846aed2119d3f968cd3c462 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/58737 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Blood derivatives awaken in regenerative medicine strategies to modulate wound healingBiomaterialsBlood derivativesDeliveryplateletregenerative medicineTissue engineeringWound healingScience & TechnologyBlood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awakened as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms. Herein, we highlight recent trends on the use biomaterials to protect, sequester and deliver these pools of biomolecules in tissue engineering and regenerative medicine approaches. Particular emphasis is given to strategies that enable to control their spatiotemporal delivery and improve the selectivity of presentation profiles of the biomolecules derived from blood derivatives rich in platelets. Finally, we discussed possible directions for biomaterials design to potentiate the aimed regenerative effects of blood derivatives and achieve efficient therapies.BBM acknowledges the financial support from FCT/MCTES (Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia, e Ensino Superior) and the Fundo Social Europeu através do Programa Operacional do Capital Humano (FSE/POCH), PD/59/2013 for PD/BD/113807/2015. MGF acknowledges European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 706996 (PrinTendon). PB acknowledges RECOGNIZE and NORTE2020 (UTAP-ICDT/CTM-BIO/0023/2014). RMD acknowledges SFRH/BPD/112459/2015.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoMendes, B. B.Gómez-Florit, M.Babo, P. S.Domingues, R. M. A.Reis, R. L.Gomes, Manuela E.2018-042018-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58737engMendes B. B., Gómez-Florit M., Babo P. S., Domingues R. M. A., Reis R. L., Gomes M. E. Blood derivatives awaken in regenerative medicine strategies to modulate wound healing, Advanced Drug Delivery Reviews, Vol. 129, pp. 376-393, doi:10.1016/j.addr.2017.12.018, 20180169-409X1872-829410.1016/j.addr.2017.12.01829288732https://linkinghub.elsevier.com/retrieve/pii/S0169-409X(17)30321-6info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:25Zoai:repositorium.sdum.uminho.pt:1822/58737Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:29.399363Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing |
title |
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing |
spellingShingle |
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing Mendes, B. B. Biomaterials Blood derivatives Delivery platelet regenerative medicine Tissue engineering Wound healing Science & Technology |
title_short |
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing |
title_full |
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing |
title_fullStr |
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing |
title_full_unstemmed |
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing |
title_sort |
Blood derivatives awaken in regenerative medicine strategies to modulate wound healing |
author |
Mendes, B. B. |
author_facet |
Mendes, B. B. Gómez-Florit, M. Babo, P. S. Domingues, R. M. A. Reis, R. L. Gomes, Manuela E. |
author_role |
author |
author2 |
Gómez-Florit, M. Babo, P. S. Domingues, R. M. A. Reis, R. L. Gomes, Manuela E. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Mendes, B. B. Gómez-Florit, M. Babo, P. S. Domingues, R. M. A. Reis, R. L. Gomes, Manuela E. |
dc.subject.por.fl_str_mv |
Biomaterials Blood derivatives Delivery platelet regenerative medicine Tissue engineering Wound healing Science & Technology |
topic |
Biomaterials Blood derivatives Delivery platelet regenerative medicine Tissue engineering Wound healing Science & Technology |
description |
Blood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awakened as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms. Herein, we highlight recent trends on the use biomaterials to protect, sequester and deliver these pools of biomolecules in tissue engineering and regenerative medicine approaches. Particular emphasis is given to strategies that enable to control their spatiotemporal delivery and improve the selectivity of presentation profiles of the biomolecules derived from blood derivatives rich in platelets. Finally, we discussed possible directions for biomaterials design to potentiate the aimed regenerative effects of blood derivatives and achieve efficient therapies. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-04 2018-04-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/58737 |
url |
http://hdl.handle.net/1822/58737 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mendes B. B., Gómez-Florit M., Babo P. S., Domingues R. M. A., Reis R. L., Gomes M. E. Blood derivatives awaken in regenerative medicine strategies to modulate wound healing, Advanced Drug Delivery Reviews, Vol. 129, pp. 376-393, doi:10.1016/j.addr.2017.12.018, 2018 0169-409X 1872-8294 10.1016/j.addr.2017.12.018 29288732 https://linkinghub.elsevier.com/retrieve/pii/S0169-409X(17)30321-6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132467526893568 |