The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals

Detalhes bibliográficos
Autor(a) principal: Júlio, Filipa
Data de Publicação: 2019
Outros Autores: Caetano, Gina, Januário, Cristina, Castelo-Branco, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/107197
https://doi.org/10.1186/s13023-019-1218-y
Resumo: Background: This study aims to test response inhibition in premanifest Huntington’s disease individuals (Pre-HD), in the context of a saccadic paradigm with working memory demands and fronto-executive load as a way to measure inhibitory control deficits and impulsive behavior in Huntington’s disease (HD). Methods: The oculomotor function of 15 Pre-HD and 22 Control individuals was assessed using an experimental paradigm comprising four horizontal saccadic tasks: prosaccade (PS), antisaccade (AS), 1- or 2-back memory prosaccade (MPS), and 1- or 2-back memory antisaccade (MAS). Success rate, latency, directional and timing errors were calculated for each task. A comprehensive battery of neuropsychological tests was also used to assess the overall cognitive functioning of study participants. Statistical correlations between oculomotor, clinical and cognitive measures were computed for the Pre-HD group. Results: Pre-HD participants showed reduced success rate in the AS task, increased direction errors in the AS and MAS tasks and decreased latency in the MAS task when compared to Controls, despite presenting similar executive and memory scores in the conventional neuropsychological tests applied. Significant associations were identified between specific AS and MAS parameters and disease-related measures, cognitive skills and other oculomotor results of Pre-HD participants. Conclusions: Our results show that oculomotor performance in premanifest Huntington’s disease deteriorates once inhibitory control, working memory and/or fronto-executive load are added to the task. A more automatic pattern of performance, including a faster response time and directionally erroneous eye movements were detected in the oculomotor behavior of the Pre-HD group—these alterations were significantly correlated with disease stage and cognitive status. Our saccadic paradigm was able to capture impulsivity and inhibitory control deficits in a group of Pre-HD individuals on average far from symptom onset, thus holding the potential to identify the earliest diseaserelated changes.
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spelling The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individualsHuntington’s diseaseCognitionOculomotor functionInhibitory controlImpulsivityAdultCognitionFemaleHumansHuntington DiseaseMaleMemory, Short-TermMiddle AgedNeuropsychological TestsReaction TimeBackground: This study aims to test response inhibition in premanifest Huntington’s disease individuals (Pre-HD), in the context of a saccadic paradigm with working memory demands and fronto-executive load as a way to measure inhibitory control deficits and impulsive behavior in Huntington’s disease (HD). Methods: The oculomotor function of 15 Pre-HD and 22 Control individuals was assessed using an experimental paradigm comprising four horizontal saccadic tasks: prosaccade (PS), antisaccade (AS), 1- or 2-back memory prosaccade (MPS), and 1- or 2-back memory antisaccade (MAS). Success rate, latency, directional and timing errors were calculated for each task. A comprehensive battery of neuropsychological tests was also used to assess the overall cognitive functioning of study participants. Statistical correlations between oculomotor, clinical and cognitive measures were computed for the Pre-HD group. Results: Pre-HD participants showed reduced success rate in the AS task, increased direction errors in the AS and MAS tasks and decreased latency in the MAS task when compared to Controls, despite presenting similar executive and memory scores in the conventional neuropsychological tests applied. Significant associations were identified between specific AS and MAS parameters and disease-related measures, cognitive skills and other oculomotor results of Pre-HD participants. Conclusions: Our results show that oculomotor performance in premanifest Huntington’s disease deteriorates once inhibitory control, working memory and/or fronto-executive load are added to the task. A more automatic pattern of performance, including a faster response time and directionally erroneous eye movements were detected in the oculomotor behavior of the Pre-HD group—these alterations were significantly correlated with disease stage and cognitive status. Our saccadic paradigm was able to capture impulsivity and inhibitory control deficits in a group of Pre-HD individuals on average far from symptom onset, thus holding the potential to identify the earliest diseaserelated changes.Springer Nature2019-11-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107197http://hdl.handle.net/10316/107197https://doi.org/10.1186/s13023-019-1218-yeng1750-1172Júlio, FilipaCaetano, GinaJanuário, CristinaCastelo-Branco, Miguelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-14T09:59:13Zoai:estudogeral.uc.pt:10316/107197Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:33.523224Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals
title The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals
spellingShingle The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals
Júlio, Filipa
Huntington’s disease
Cognition
Oculomotor function
Inhibitory control
Impulsivity
Adult
Cognition
Female
Humans
Huntington Disease
Male
Memory, Short-Term
Middle Aged
Neuropsychological Tests
Reaction Time
title_short The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals
title_full The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals
title_fullStr The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals
title_full_unstemmed The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals
title_sort The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals
author Júlio, Filipa
author_facet Júlio, Filipa
Caetano, Gina
Januário, Cristina
Castelo-Branco, Miguel
author_role author
author2 Caetano, Gina
Januário, Cristina
Castelo-Branco, Miguel
author2_role author
author
author
dc.contributor.author.fl_str_mv Júlio, Filipa
Caetano, Gina
Januário, Cristina
Castelo-Branco, Miguel
dc.subject.por.fl_str_mv Huntington’s disease
Cognition
Oculomotor function
Inhibitory control
Impulsivity
Adult
Cognition
Female
Humans
Huntington Disease
Male
Memory, Short-Term
Middle Aged
Neuropsychological Tests
Reaction Time
topic Huntington’s disease
Cognition
Oculomotor function
Inhibitory control
Impulsivity
Adult
Cognition
Female
Humans
Huntington Disease
Male
Memory, Short-Term
Middle Aged
Neuropsychological Tests
Reaction Time
description Background: This study aims to test response inhibition in premanifest Huntington’s disease individuals (Pre-HD), in the context of a saccadic paradigm with working memory demands and fronto-executive load as a way to measure inhibitory control deficits and impulsive behavior in Huntington’s disease (HD). Methods: The oculomotor function of 15 Pre-HD and 22 Control individuals was assessed using an experimental paradigm comprising four horizontal saccadic tasks: prosaccade (PS), antisaccade (AS), 1- or 2-back memory prosaccade (MPS), and 1- or 2-back memory antisaccade (MAS). Success rate, latency, directional and timing errors were calculated for each task. A comprehensive battery of neuropsychological tests was also used to assess the overall cognitive functioning of study participants. Statistical correlations between oculomotor, clinical and cognitive measures were computed for the Pre-HD group. Results: Pre-HD participants showed reduced success rate in the AS task, increased direction errors in the AS and MAS tasks and decreased latency in the MAS task when compared to Controls, despite presenting similar executive and memory scores in the conventional neuropsychological tests applied. Significant associations were identified between specific AS and MAS parameters and disease-related measures, cognitive skills and other oculomotor results of Pre-HD participants. Conclusions: Our results show that oculomotor performance in premanifest Huntington’s disease deteriorates once inhibitory control, working memory and/or fronto-executive load are added to the task. A more automatic pattern of performance, including a faster response time and directionally erroneous eye movements were detected in the oculomotor behavior of the Pre-HD group—these alterations were significantly correlated with disease stage and cognitive status. Our saccadic paradigm was able to capture impulsivity and inhibitory control deficits in a group of Pre-HD individuals on average far from symptom onset, thus holding the potential to identify the earliest diseaserelated changes.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-08
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/107197
http://hdl.handle.net/10316/107197
https://doi.org/10.1186/s13023-019-1218-y
url http://hdl.handle.net/10316/107197
https://doi.org/10.1186/s13023-019-1218-y
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1750-1172
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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