The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/107197 https://doi.org/10.1186/s13023-019-1218-y |
Resumo: | Background: This study aims to test response inhibition in premanifest Huntington’s disease individuals (Pre-HD), in the context of a saccadic paradigm with working memory demands and fronto-executive load as a way to measure inhibitory control deficits and impulsive behavior in Huntington’s disease (HD). Methods: The oculomotor function of 15 Pre-HD and 22 Control individuals was assessed using an experimental paradigm comprising four horizontal saccadic tasks: prosaccade (PS), antisaccade (AS), 1- or 2-back memory prosaccade (MPS), and 1- or 2-back memory antisaccade (MAS). Success rate, latency, directional and timing errors were calculated for each task. A comprehensive battery of neuropsychological tests was also used to assess the overall cognitive functioning of study participants. Statistical correlations between oculomotor, clinical and cognitive measures were computed for the Pre-HD group. Results: Pre-HD participants showed reduced success rate in the AS task, increased direction errors in the AS and MAS tasks and decreased latency in the MAS task when compared to Controls, despite presenting similar executive and memory scores in the conventional neuropsychological tests applied. Significant associations were identified between specific AS and MAS parameters and disease-related measures, cognitive skills and other oculomotor results of Pre-HD participants. Conclusions: Our results show that oculomotor performance in premanifest Huntington’s disease deteriorates once inhibitory control, working memory and/or fronto-executive load are added to the task. A more automatic pattern of performance, including a faster response time and directionally erroneous eye movements were detected in the oculomotor behavior of the Pre-HD group—these alterations were significantly correlated with disease stage and cognitive status. Our saccadic paradigm was able to capture impulsivity and inhibitory control deficits in a group of Pre-HD individuals on average far from symptom onset, thus holding the potential to identify the earliest diseaserelated changes. |
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The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individualsHuntington’s diseaseCognitionOculomotor functionInhibitory controlImpulsivityAdultCognitionFemaleHumansHuntington DiseaseMaleMemory, Short-TermMiddle AgedNeuropsychological TestsReaction TimeBackground: This study aims to test response inhibition in premanifest Huntington’s disease individuals (Pre-HD), in the context of a saccadic paradigm with working memory demands and fronto-executive load as a way to measure inhibitory control deficits and impulsive behavior in Huntington’s disease (HD). Methods: The oculomotor function of 15 Pre-HD and 22 Control individuals was assessed using an experimental paradigm comprising four horizontal saccadic tasks: prosaccade (PS), antisaccade (AS), 1- or 2-back memory prosaccade (MPS), and 1- or 2-back memory antisaccade (MAS). Success rate, latency, directional and timing errors were calculated for each task. A comprehensive battery of neuropsychological tests was also used to assess the overall cognitive functioning of study participants. Statistical correlations between oculomotor, clinical and cognitive measures were computed for the Pre-HD group. Results: Pre-HD participants showed reduced success rate in the AS task, increased direction errors in the AS and MAS tasks and decreased latency in the MAS task when compared to Controls, despite presenting similar executive and memory scores in the conventional neuropsychological tests applied. Significant associations were identified between specific AS and MAS parameters and disease-related measures, cognitive skills and other oculomotor results of Pre-HD participants. Conclusions: Our results show that oculomotor performance in premanifest Huntington’s disease deteriorates once inhibitory control, working memory and/or fronto-executive load are added to the task. A more automatic pattern of performance, including a faster response time and directionally erroneous eye movements were detected in the oculomotor behavior of the Pre-HD group—these alterations were significantly correlated with disease stage and cognitive status. Our saccadic paradigm was able to capture impulsivity and inhibitory control deficits in a group of Pre-HD individuals on average far from symptom onset, thus holding the potential to identify the earliest diseaserelated changes.Springer Nature2019-11-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107197http://hdl.handle.net/10316/107197https://doi.org/10.1186/s13023-019-1218-yeng1750-1172Júlio, FilipaCaetano, GinaJanuário, CristinaCastelo-Branco, Miguelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-14T09:59:13Zoai:estudogeral.uc.pt:10316/107197Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:33.523224Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals |
title |
The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals |
spellingShingle |
The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals Júlio, Filipa Huntington’s disease Cognition Oculomotor function Inhibitory control Impulsivity Adult Cognition Female Humans Huntington Disease Male Memory, Short-Term Middle Aged Neuropsychological Tests Reaction Time |
title_short |
The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals |
title_full |
The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals |
title_fullStr |
The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals |
title_full_unstemmed |
The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals |
title_sort |
The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals |
author |
Júlio, Filipa |
author_facet |
Júlio, Filipa Caetano, Gina Januário, Cristina Castelo-Branco, Miguel |
author_role |
author |
author2 |
Caetano, Gina Januário, Cristina Castelo-Branco, Miguel |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Júlio, Filipa Caetano, Gina Januário, Cristina Castelo-Branco, Miguel |
dc.subject.por.fl_str_mv |
Huntington’s disease Cognition Oculomotor function Inhibitory control Impulsivity Adult Cognition Female Humans Huntington Disease Male Memory, Short-Term Middle Aged Neuropsychological Tests Reaction Time |
topic |
Huntington’s disease Cognition Oculomotor function Inhibitory control Impulsivity Adult Cognition Female Humans Huntington Disease Male Memory, Short-Term Middle Aged Neuropsychological Tests Reaction Time |
description |
Background: This study aims to test response inhibition in premanifest Huntington’s disease individuals (Pre-HD), in the context of a saccadic paradigm with working memory demands and fronto-executive load as a way to measure inhibitory control deficits and impulsive behavior in Huntington’s disease (HD). Methods: The oculomotor function of 15 Pre-HD and 22 Control individuals was assessed using an experimental paradigm comprising four horizontal saccadic tasks: prosaccade (PS), antisaccade (AS), 1- or 2-back memory prosaccade (MPS), and 1- or 2-back memory antisaccade (MAS). Success rate, latency, directional and timing errors were calculated for each task. A comprehensive battery of neuropsychological tests was also used to assess the overall cognitive functioning of study participants. Statistical correlations between oculomotor, clinical and cognitive measures were computed for the Pre-HD group. Results: Pre-HD participants showed reduced success rate in the AS task, increased direction errors in the AS and MAS tasks and decreased latency in the MAS task when compared to Controls, despite presenting similar executive and memory scores in the conventional neuropsychological tests applied. Significant associations were identified between specific AS and MAS parameters and disease-related measures, cognitive skills and other oculomotor results of Pre-HD participants. Conclusions: Our results show that oculomotor performance in premanifest Huntington’s disease deteriorates once inhibitory control, working memory and/or fronto-executive load are added to the task. A more automatic pattern of performance, including a faster response time and directionally erroneous eye movements were detected in the oculomotor behavior of the Pre-HD group—these alterations were significantly correlated with disease stage and cognitive status. Our saccadic paradigm was able to capture impulsivity and inhibitory control deficits in a group of Pre-HD individuals on average far from symptom onset, thus holding the potential to identify the earliest diseaserelated changes. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/107197 http://hdl.handle.net/10316/107197 https://doi.org/10.1186/s13023-019-1218-y |
url |
http://hdl.handle.net/10316/107197 https://doi.org/10.1186/s13023-019-1218-y |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1750-1172 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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