The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2

Detalhes bibliográficos
Autor(a) principal: Teixeira, Rita I.
Data de Publicação: 2022
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/163215
Resumo: "The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to over 6.6 million deaths worldwide, as of 27 November 2022. The SARS-CoV-2 infection mechanism involves the viral binding to the angiotensin-converting enzyme 2 (ACE2) host receptor through the Spike (S) protein receptor-binding domain (RBD). Thus, understanding the molecular details of binding is of pharmaceutical interest. Nevertheless, the unbound RBD presents conformational changes in the “ridge” region that are hypothesized to also affect receptor recognition.(...)"
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spelling The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2SARS-CoV-2Receptor-binding domain (RBD)human Angiotensin-converting enzyme 2 (hACE2)Variant of Concern (VOC)Domínio/Área Científica::Ciências Naturais"The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to over 6.6 million deaths worldwide, as of 27 November 2022. The SARS-CoV-2 infection mechanism involves the viral binding to the angiotensin-converting enzyme 2 (ACE2) host receptor through the Spike (S) protein receptor-binding domain (RBD). Thus, understanding the molecular details of binding is of pharmaceutical interest. Nevertheless, the unbound RBD presents conformational changes in the “ridge” region that are hypothesized to also affect receptor recognition.(...)"Lousa, DianaVicente, JoãoRUNTeixeira, Rita I.2024-02-07T17:00:18Z2023-02-022022-11-012023-02-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/163215TID:203518772enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:46:20Zoai:run.unl.pt:10362/163215Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:18.990746Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2
title The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2
spellingShingle The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2
Teixeira, Rita I.
SARS-CoV-2
Receptor-binding domain (RBD)
human Angiotensin-converting enzyme 2 (hACE2)
Variant of Concern (VOC)
Domínio/Área Científica::Ciências Naturais
title_short The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2
title_full The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2
title_fullStr The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2
title_full_unstemmed The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2
title_sort The impact of SARS-CoV-2 Omicron variant on the receptor binding domain conformational dynamics and interaction with human ACE2
author Teixeira, Rita I.
author_facet Teixeira, Rita I.
author_role author
dc.contributor.none.fl_str_mv Lousa, Diana
Vicente, João
RUN
dc.contributor.author.fl_str_mv Teixeira, Rita I.
dc.subject.por.fl_str_mv SARS-CoV-2
Receptor-binding domain (RBD)
human Angiotensin-converting enzyme 2 (hACE2)
Variant of Concern (VOC)
Domínio/Área Científica::Ciências Naturais
topic SARS-CoV-2
Receptor-binding domain (RBD)
human Angiotensin-converting enzyme 2 (hACE2)
Variant of Concern (VOC)
Domínio/Área Científica::Ciências Naturais
description "The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to over 6.6 million deaths worldwide, as of 27 November 2022. The SARS-CoV-2 infection mechanism involves the viral binding to the angiotensin-converting enzyme 2 (ACE2) host receptor through the Spike (S) protein receptor-binding domain (RBD). Thus, understanding the molecular details of binding is of pharmaceutical interest. Nevertheless, the unbound RBD presents conformational changes in the “ridge” region that are hypothesized to also affect receptor recognition.(...)"
publishDate 2022
dc.date.none.fl_str_mv 2022-11-01
2023-02-02
2023-02-02T00:00:00Z
2024-02-07T17:00:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163215
TID:203518772
url http://hdl.handle.net/10362/163215
identifier_str_mv TID:203518772
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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