Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/108735 https://doi.org/10.18632/oncotarget.11760 |
Resumo: | Opportunistic gut infections and chronic inflammation, in particular due to overgrowth of Candida albicans present in the gut microbiota, are increasingly reported in the elder population. In aged, adult and young mice, we now compared the relative intestinal over-colonization by ingested C. albicans and their translocation to other organs, focusing on the role of adenosine A2A receptors that are a main stop signal of inflammation. We report that elderly mice are more prone to over-colonization by C. albicans than adult and young mice. This fungal over-growth seems to be related with higher growth rate in intestinal lumen, independent of gut tissues invasion, but resulting in higher GI tract inflammation. We observed a particularly high colonization of the stomach, with increased rate of yeast-to-hypha transition in aged mice. We found a correlation between A2A receptor density and tissue damage due to yeast infection: comparing with young and adults, aged mice have a lower gut A2A receptor density and C. albicans infection failed to increase it. In conclusion, this study shows that aged mice have a lower ability to cope with inflammation due to C. albicans over-colonization, associated with an inability to adaptively adjust adenosine A2A receptors density. |
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Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderlyageinginfectiongutCandida albicansadenosine A2A receptorsGerotargetAnimalsCandidiasisFecesGastrointestinal TractInflammationMaleMiceMice, Inbred C57BLReceptor, Adenosine A2AStomachAgingCandida albicansOpportunistic gut infections and chronic inflammation, in particular due to overgrowth of Candida albicans present in the gut microbiota, are increasingly reported in the elder population. In aged, adult and young mice, we now compared the relative intestinal over-colonization by ingested C. albicans and their translocation to other organs, focusing on the role of adenosine A2A receptors that are a main stop signal of inflammation. We report that elderly mice are more prone to over-colonization by C. albicans than adult and young mice. This fungal over-growth seems to be related with higher growth rate in intestinal lumen, independent of gut tissues invasion, but resulting in higher GI tract inflammation. We observed a particularly high colonization of the stomach, with increased rate of yeast-to-hypha transition in aged mice. We found a correlation between A2A receptor density and tissue damage due to yeast infection: comparing with young and adults, aged mice have a lower gut A2A receptor density and C. albicans infection failed to increase it. In conclusion, this study shows that aged mice have a lower ability to cope with inflammation due to C. albicans over-colonization, associated with an inability to adaptively adjust adenosine A2A receptors density.Impact Journals2016-09-27info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108735http://hdl.handle.net/10316/108735https://doi.org/10.18632/oncotarget.11760eng1949-2553Rodrigues, LisaMiranda, Isabel M.Andrade, Geanne M.Mota, MartaCortes, LuísaRodrigues, Acácio G.Cunha, Rodrigo A.Gonçalves, Teresainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-11T10:50:02Zoai:estudogeral.uc.pt:10316/108735Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:00.365074Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly |
title |
Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly |
spellingShingle |
Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly Rodrigues, Lisa ageing infection gut Candida albicans adenosine A2A receptors Gerotarget Animals Candidiasis Feces Gastrointestinal Tract Inflammation Male Mice Mice, Inbred C57BL Receptor, Adenosine A2A Stomach Aging Candida albicans |
title_short |
Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly |
title_full |
Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly |
title_fullStr |
Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly |
title_full_unstemmed |
Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly |
title_sort |
Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly |
author |
Rodrigues, Lisa |
author_facet |
Rodrigues, Lisa Miranda, Isabel M. Andrade, Geanne M. Mota, Marta Cortes, Luísa Rodrigues, Acácio G. Cunha, Rodrigo A. Gonçalves, Teresa |
author_role |
author |
author2 |
Miranda, Isabel M. Andrade, Geanne M. Mota, Marta Cortes, Luísa Rodrigues, Acácio G. Cunha, Rodrigo A. Gonçalves, Teresa |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Lisa Miranda, Isabel M. Andrade, Geanne M. Mota, Marta Cortes, Luísa Rodrigues, Acácio G. Cunha, Rodrigo A. Gonçalves, Teresa |
dc.subject.por.fl_str_mv |
ageing infection gut Candida albicans adenosine A2A receptors Gerotarget Animals Candidiasis Feces Gastrointestinal Tract Inflammation Male Mice Mice, Inbred C57BL Receptor, Adenosine A2A Stomach Aging Candida albicans |
topic |
ageing infection gut Candida albicans adenosine A2A receptors Gerotarget Animals Candidiasis Feces Gastrointestinal Tract Inflammation Male Mice Mice, Inbred C57BL Receptor, Adenosine A2A Stomach Aging Candida albicans |
description |
Opportunistic gut infections and chronic inflammation, in particular due to overgrowth of Candida albicans present in the gut microbiota, are increasingly reported in the elder population. In aged, adult and young mice, we now compared the relative intestinal over-colonization by ingested C. albicans and their translocation to other organs, focusing on the role of adenosine A2A receptors that are a main stop signal of inflammation. We report that elderly mice are more prone to over-colonization by C. albicans than adult and young mice. This fungal over-growth seems to be related with higher growth rate in intestinal lumen, independent of gut tissues invasion, but resulting in higher GI tract inflammation. We observed a particularly high colonization of the stomach, with increased rate of yeast-to-hypha transition in aged mice. We found a correlation between A2A receptor density and tissue damage due to yeast infection: comparing with young and adults, aged mice have a lower gut A2A receptor density and C. albicans infection failed to increase it. In conclusion, this study shows that aged mice have a lower ability to cope with inflammation due to C. albicans over-colonization, associated with an inability to adaptively adjust adenosine A2A receptors density. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-27 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/108735 http://hdl.handle.net/10316/108735 https://doi.org/10.18632/oncotarget.11760 |
url |
http://hdl.handle.net/10316/108735 https://doi.org/10.18632/oncotarget.11760 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1949-2553 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Impact Journals |
publisher.none.fl_str_mv |
Impact Journals |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134133714157568 |