Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/6636 |
Resumo: | Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1157) |
id |
RCAP_7510ad21ba079f00b15f36fa6917b115 |
---|---|
oai_identifier_str |
oai:repositorio.insa.pt:10400.18/6636 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Networks of mRNA Processing and Alternative Splicing Regulation in Health and DiseaseGene Expression ProfilingAlternative SplicingRNA, MessengerSequence Analysis, RNATranscriptomeVias de Transdução de Sinal e Patologias AssociadasPart of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1157)mRNA processing events introduce an intricate layer of complexity into gene expression processes, supporting a tremendous level of diversification of the genome's coding and regulatory potential, particularly in vertebrate species. The recent development of massive parallel sequencing methods and their adaptation to the identification and quantification of different RNA species and the dynamics of mRNA metabolism and processing has generated an unprecedented view over the regulatory networks that are established at this level, which contribute to sustain developmental, tissue specific or disease specific gene expression programs. In this chapter, we provide an overview of the recent evolution of transcriptome profiling methods and the surprising insights that have emerged in recent years regarding distinct mRNA processing events - from the 5' end to the 3' end of the molecule.Springer VerlagRepositório Científico do Instituto Nacional de SaúdeJordan, PeterGonçalves, VâniaFernandes, SaraMarques, TâniaPereira, MarceloGama-Carvalho, Margarida2020-05-09T15:42:17Z2019-07-252019-07-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6636engAdv Exp Med Biol. 2019;1157:1-27. doi: 10.1007/978-3-030-19966-1_1. Epub 2019 Jul 25. Review0065-259810.1007/978-3-030-19966-1_1info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:46Zoai:repositorio.insa.pt:10400.18/6636Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:43.413712Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease |
title |
Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease |
spellingShingle |
Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease Jordan, Peter Gene Expression Profiling Alternative Splicing RNA, Messenger Sequence Analysis, RNA Transcriptome Vias de Transdução de Sinal e Patologias Associadas |
title_short |
Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease |
title_full |
Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease |
title_fullStr |
Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease |
title_full_unstemmed |
Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease |
title_sort |
Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease |
author |
Jordan, Peter |
author_facet |
Jordan, Peter Gonçalves, Vânia Fernandes, Sara Marques, Tânia Pereira, Marcelo Gama-Carvalho, Margarida |
author_role |
author |
author2 |
Gonçalves, Vânia Fernandes, Sara Marques, Tânia Pereira, Marcelo Gama-Carvalho, Margarida |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Jordan, Peter Gonçalves, Vânia Fernandes, Sara Marques, Tânia Pereira, Marcelo Gama-Carvalho, Margarida |
dc.subject.por.fl_str_mv |
Gene Expression Profiling Alternative Splicing RNA, Messenger Sequence Analysis, RNA Transcriptome Vias de Transdução de Sinal e Patologias Associadas |
topic |
Gene Expression Profiling Alternative Splicing RNA, Messenger Sequence Analysis, RNA Transcriptome Vias de Transdução de Sinal e Patologias Associadas |
description |
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1157) |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07-25 2019-07-25T00:00:00Z 2020-05-09T15:42:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6636 |
url |
http://hdl.handle.net/10400.18/6636 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Adv Exp Med Biol. 2019;1157:1-27. doi: 10.1007/978-3-030-19966-1_1. Epub 2019 Jul 25. Review 0065-2598 10.1007/978-3-030-19966-1_1 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Verlag |
publisher.none.fl_str_mv |
Springer Verlag |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132161742209024 |