Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/98759 https://doi.org/10.1186/s12864-021-08279-6 |
Resumo: | Klebsiella pneumoniae are ubiquitous bacteria and recognized multidrug-resistant opportunistic pathogens that can be released into the environment, mainly through sewage, where they can survive even after wastewater treatment. A major question is if once released into wastewater, the selection of lineages missing clinically-relevant traits may occur. Wastewater (n = 25) and clinical (n = 34) 3rd generation cephalosporin-resistant K. pneumoniae isolates were compared based on phenotypic, genotypic and genomic analyses. |
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Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?Antibiotic resistanceClinicalComparative genomicsKlebsiella pneumoniaeWastewaterAnti-Bacterial AgentsCephalosporinsDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsWaste Waterbeta-LactamasesKlebsiella InfectionsKlebsiella pneumoniaeKlebsiella pneumoniae are ubiquitous bacteria and recognized multidrug-resistant opportunistic pathogens that can be released into the environment, mainly through sewage, where they can survive even after wastewater treatment. A major question is if once released into wastewater, the selection of lineages missing clinically-relevant traits may occur. Wastewater (n = 25) and clinical (n = 34) 3rd generation cephalosporin-resistant K. pneumoniae isolates were compared based on phenotypic, genotypic and genomic analyses.This work was also financed by FCT in the scope of the project UIDB/04565/2020 and UIDP/04565/2020 of the Research Unit Institute for Bioengineering and Biosciences - iBB and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy - i4HB. The authors also acknowledge FCT (STARE Water JPI/0001/2013, NanoDiaBac ENMed/0001/2014, UID/Multi/50016/2019, UIDP/50017/2020 + UIDB/50017/2020). JR was supported by the International PhD Programme in Biotechnology BIOTECH.DOC (NORTE 08 5369 FSE 000007) and by FEMS Research and Training Grant (FEMS GO 2017 008).BMC2022-01-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/98759http://hdl.handle.net/10316/98759https://doi.org/10.1186/s12864-021-08279-6eng1471-2164Rocha, JaquelineFerreira, CatarinaMil-Homens, DalilaBusquets, AntonioFialho, Arsénio MHenriques, IsabelGomila, MargaritaManaia, Célia M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-02-08T21:42:26Zoai:estudogeral.uc.pt:10316/98759Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:16:30.625788Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common? |
title |
Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common? |
spellingShingle |
Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common? Rocha, Jaqueline Antibiotic resistance Clinical Comparative genomics Klebsiella pneumoniae Wastewater Anti-Bacterial Agents Cephalosporins Drug Resistance, Multiple, Bacterial Humans Microbial Sensitivity Tests Waste Water beta-Lactamases Klebsiella Infections Klebsiella pneumoniae |
title_short |
Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common? |
title_full |
Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common? |
title_fullStr |
Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common? |
title_full_unstemmed |
Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common? |
title_sort |
Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common? |
author |
Rocha, Jaqueline |
author_facet |
Rocha, Jaqueline Ferreira, Catarina Mil-Homens, Dalila Busquets, Antonio Fialho, Arsénio M Henriques, Isabel Gomila, Margarita Manaia, Célia M. |
author_role |
author |
author2 |
Ferreira, Catarina Mil-Homens, Dalila Busquets, Antonio Fialho, Arsénio M Henriques, Isabel Gomila, Margarita Manaia, Célia M. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Rocha, Jaqueline Ferreira, Catarina Mil-Homens, Dalila Busquets, Antonio Fialho, Arsénio M Henriques, Isabel Gomila, Margarita Manaia, Célia M. |
dc.subject.por.fl_str_mv |
Antibiotic resistance Clinical Comparative genomics Klebsiella pneumoniae Wastewater Anti-Bacterial Agents Cephalosporins Drug Resistance, Multiple, Bacterial Humans Microbial Sensitivity Tests Waste Water beta-Lactamases Klebsiella Infections Klebsiella pneumoniae |
topic |
Antibiotic resistance Clinical Comparative genomics Klebsiella pneumoniae Wastewater Anti-Bacterial Agents Cephalosporins Drug Resistance, Multiple, Bacterial Humans Microbial Sensitivity Tests Waste Water beta-Lactamases Klebsiella Infections Klebsiella pneumoniae |
description |
Klebsiella pneumoniae are ubiquitous bacteria and recognized multidrug-resistant opportunistic pathogens that can be released into the environment, mainly through sewage, where they can survive even after wastewater treatment. A major question is if once released into wastewater, the selection of lineages missing clinically-relevant traits may occur. Wastewater (n = 25) and clinical (n = 34) 3rd generation cephalosporin-resistant K. pneumoniae isolates were compared based on phenotypic, genotypic and genomic analyses. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-22 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/98759 http://hdl.handle.net/10316/98759 https://doi.org/10.1186/s12864-021-08279-6 |
url |
http://hdl.handle.net/10316/98759 https://doi.org/10.1186/s12864-021-08279-6 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1471-2164 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
BMC |
publisher.none.fl_str_mv |
BMC |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134061503971328 |